False-Positive Results in a Population-Based Colorectal Screening Program: Cumulative Risk from 2000 to 2017 with Biennial Screening

AbstractBackground:Five cases of primary varicella zoster virus (VZV) were diagnosed among hospital healthcare workers (HCWs). All had complied with a pre-employment VZV screening program and had been considered immune.Objectives:To summarize the investigation of VZV among un-immunized HCWs and to provide recommendations for avoiding false-positive serologic tests.Design:Risk of transmission of VZV to susceptible HCWs is minimized through serologic screening. Varicella vaccine is recommended for susceptible HCWs. A commercially available latex bead agglutination assay (LA) is widely used because it is rapid and easy to perform. LA was compared with the whole-cell varicella ELISA standardized in the Centers for Disease Control and Prevention (CDC) National Herpes Laboratory.Setting/Population:Large inner-city, tertiarycare hospital with a diverse employee population.Results:In a year, 5 HCWs presented with laboratory-confirmed primary varicella infection. Four had VZV exposures 2 weeks prior to presentation. All had documented positive VZV titers by LA performed at hire. None were offered VZV vaccination. The original LAs were judged false-positives.Intervention/Follow-Up Investigation:Fifty-three consecutive VZV LA samples from the hospital laboratory were retested at the CDC. Forty-four samples concurred. Of the remaining 9, 4 were positive by hospital LA but negative by CDC IgG ELISA. Four were equivocal by hospital LA but negative by CDC IgG ELISA and LA. One was positive by hospital LA but negative by LA and equivocal by ELISA at the CDC.Conclusion:LA may be prone to false-positive results and inappropriate for screening hospital HCWs.

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Estimating the Cumulative Risk of a False-Positive Test in a Repeated Screening Program

Biometrics ◽

10.1111/j.0006-341x.2004.00214.x ◽

2004 ◽

Vol 60 (3) ◽

pp. 651-660 ◽

Cited By ~ 13

Author(s):

Jian-Lun Xu ◽

Richard M. Fagerstrom ◽

Philip C. Prorok ◽

Barnett S. Kramer

Keyword(s):

False Positive ◽

Screening Program ◽

Cumulative Risk ◽

Positive Test ◽

False Positive Test

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Mo1083 Assessment of a Colonoscopy Triage Sheet for Use in a Province-Wide Population-Based Colorectal Screening Program

Gastroenterology ◽

10.1016/s0016-5085(14)61998-3 ◽

2014 ◽

Vol 146 (5) ◽

pp. S-552-S-553

Author(s):

Nour Sharara ◽

Maida J. Sewitch ◽

Sabrina Nolan ◽

Myriam Martel ◽

Maria-Helena Dias ◽

...

Keyword(s):

Screening Program ◽

Population Based ◽

Colorectal Screening ◽

Wide Population

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Trends in screening for colorectal cancer in France

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.1538 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. 1538-1538

Author(s):

J. Viguier ◽

A. Calazel Benque ◽

M. Mahjoubi ◽

X. Pivot ◽

J. Morère ◽

...

Keyword(s):

Colorectal Cancer ◽

Screening Program ◽

Age Groups ◽

Target Population ◽

Population Based ◽

Screening Programs ◽

The Family ◽

Objective Rate ◽

Nationwide Observational Study ◽

Colorectal Screening

1538 Background: In France, after a pilot population-based screening program in 23 districts (2002–2003), a national organized program was progressively implemented starting in 2005. The EDIFICE 2 survey was conducted in 2008, 3 years after EDIFICE 1, to provide a better understanding of French people's participation in colorectal screening programs and to assess the evolution between the two periods. Methods: This second nationwide observational study, EDIFICE 2, was conducted in January 2008 among a representative sample of 1,801 subjects aged between 40 and 85 years old. The analysis focused on the target population of the national screening program (50–74 years old). Results: In 2008, 38% of subjects between 50 and 74 years (N = 928) had undergone a screening test for colorectal cancer (including fecal test or colonoscopy) versus 25% in 2005 (p < 0.05); 32% of the unscreened population (N = 575) planned to undergo a test. Colorectal cancer screening increased significantly in all age groups, especially between 65 and 69 years, and for both sexes. A most significant increase can be observed in districts with pilot programme (+ 21%). Factors influencing the probability of screening were: being encouraged by the family circle, living in a couple, the existence of a case of cancer (especially colorectal cancer) in the family circle, and fear of colorectal cancer. The main reasons for not performing the screening were: not feeling concerned, no recommendation by the GP, carelessness, no symptoms, and fear of exams or results. Conclusions: The objective rate of participation (50%), can be reached by motivating the unscreened population already planning to perform a test. The results in the pilot districts show the effectiveness of an organization of the screening. This trend of increasing testing will probably be confirmed in the future if the reasons for non-attendance in an organized program are addressed. No significant financial relationships to disclose.

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Populációalapú „pilot” colorectalis rákszűrés eredményessége. Csongrád megye, 2015

Orvosi Hetilap ◽

10.1556/650.2017.30822 ◽

2017 ◽

Vol 158 (42) ◽

pp. 1658-1667

Author(s):

Mariann Rutka ◽

Tamás Molnár ◽

Renáta Bor ◽

Klaudia Farkas ◽

Anna Fábián ◽

...

Keyword(s):

Colorectal Cancer ◽

Blood Test ◽

Screening Program ◽

Participation Rate ◽

Population Based ◽

Screening Colonoscopy ◽

Average Risk ◽

Short Term ◽

Term Efficacy ◽

Colorectal Screening

Abstract: Introduction: In Hungary, a nationwide colorectal screening program is about to be introduced in order to improve the extremely high mortality rate of colorectal cancer (CRC). Aim: The aim of our study was to summarize experiences and assess short-term efficacy of the population-based pilot colorectal screening program in 2015 in Csongrád County, Hungary. Patients and method: Asymptomatic individuals between the ages of 50 and 70 with average risk of colorectal cancer participated in the program that was based on the two-step screening method (i.e. immune fecal blood test and colonoscopy). The short-term efficacy of the screening program was assessed as the change in total CRC incidence and initial tumor stage in the screening year (2015) compared to a control year (2013) in Szeged and its surroundings. Participation rate, positive predictive value of the screening methods and tumor detection rate was assessed. Results: 22,130 individuals were invited, the participation rate was 46.4%. Immune fecal blood test proved to be non-negative in 1,343 cases (13%), screening colonoscopy was performed in 766 of them (7.5%). Total colonoscopy was performed in 711 individuals. Based on the reports, adenoma was detected in 358 (50.3%) and malignancy in 42 (5.9%) individuals. In the background population, the incidence of colon cancer was significantly higher (183 vs. 228; p = 0.026) and was diagnosed at significantly earlier stage (p = 0.002). Lymph node involvement was significantly lower in 2015 (48.3% vs. 37.1%; p = 0.049). Conclusion: The Csongrád county population-based colorectal cancer screening was evidently successful on the short term considering participation rate, and the changes in CRC incidence and stage, thus its national extension is necessary. Orv Hetil. 2017; 158(42): 1658–1667.

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