Antiangiogenic and Antitumor Activity of 6-(2-Aminoethyl)Amino-5-Chlorouracil, a Novel Small-Molecule Inhibitor of Thymidine Phosphorylase, in Combination with the Vascular Endothelial Growth Factor-Trap

Growth Factor ◽

Antitumor Activity ◽

Small Molecule ◽

Thymidine Phosphorylase ◽

Small Molecule Inhibitor ◽

Vascular Endothelial ◽

Molecule Inhibitor ◽

AAL881, a Novel Small Molecule Inhibitor of RAF and Vascular Endothelial Growth Factor Receptor Activities, Blocks the Growth of Malignant Glioma

Cancer Research ◽

10.1158/0008-5472.can-06-0284 ◽

2006 ◽

Vol 66 (17) ◽

pp. 8722-8730 ◽

Cited By ~ 35

Author(s):

Sith Sathornsumetee ◽

Anita B. Hjelmeland ◽

Stephen T. Keir ◽

Roger E. McLendon ◽

David Batt ◽

...

Keyword(s):

Growth Factor ◽

Malignant Glioma ◽

Small Molecule ◽

Growth Factor Receptor ◽

Small Molecule Inhibitor ◽

Vascular Endothelial ◽

Molecule Inhibitor ◽

Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.040337597 ◽

2000 ◽

Vol 97 (6) ◽

pp. 2573-2578 ◽

Cited By ~ 202

Author(s):

M. L. Gagnon ◽

D. R. Bielenberg ◽

Z.'e. Gechtman ◽

H.-Q. Miao ◽

S. Takashima ◽

...

Keyword(s):

Growth Factor ◽

Antitumor Activity ◽

Vascular Endothelial ◽

Neuropilin 1 ◽

In Vivo Expression ◽

Broad Antitumor Activity in Breast Cancer Xenografts by Motesanib, a Highly Selective, Oral Inhibitor of Vascular Endothelial Growth Factor, Platelet-Derived Growth Factor, and Kit Receptors

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-08-1155 ◽

2008 ◽

Vol 15 (1) ◽

pp. 110-118 ◽

Cited By ~ 27

Author(s):

Angela Coxon ◽

Tammy Bush ◽

Douglas Saffran ◽

Stephen Kaufman ◽

Brian Belmontes ◽

...

Keyword(s):

Breast Cancer ◽

Growth Factor ◽

Antitumor Activity ◽

Platelet Derived Growth Factor ◽

Vascular Endothelial ◽

Endothelial Growth Factor ◽

Breast Cancer Xenografts

Expressions of thymidine phosphorylase (dThdPase) and vascular endothelial growth factor on angiogenesis in intestinal-type gastric carcinoma.

Oncology Reports ◽

10.3892/or.7.4.831 ◽

2000 ◽

Cited By ~ 1

Author(s):

T Sakatani ◽

E Okamoto ◽

S Tsujitani ◽

M Ikeguchi ◽

N Kaibara ◽

...

Keyword(s):

Growth Factor ◽

Gastric Carcinoma ◽

Thymidine Phosphorylase ◽

Intestinal Type ◽

Vascular Endothelial ◽

Phase II Study of SU5416, a Small Molecule Vascular Endothelial Growth Factor Tyrosine Kinase Receptor Inhibitor, in Patients with Refractory Multiple Myeloma

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-0221-3 ◽

2004 ◽

Vol 10 (1) ◽

pp. 88-95 ◽

Cited By ~ 86

Author(s):

Maurizio Zangari ◽

Elias Anaissie ◽

Alison Stopeck ◽

Alyssa Morimoto ◽

Nguyen Tan ◽

...

Keyword(s):

Multiple Myeloma ◽

Growth Factor ◽

Tyrosine Kinase ◽

Small Molecule ◽

Phase Ii Study ◽

Tyrosine Kinase Receptor ◽

Vascular Endothelial ◽

Endothelial Growth Factor ◽

Receptor Inhibitor

Microplate-based screening for small molecule inhibitors of neuropilin-2/vascular endothelial growth factor-C interactions

Analytical Biochemistry ◽

10.1016/j.ab.2014.02.017 ◽

2014 ◽

Vol 453 ◽

pp. 4-6 ◽

Cited By ~ 8

Author(s):

Matthew W. Parker ◽

Craig W. Vander Kooi

Keyword(s):

Growth Factor ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Vascular Endothelial ◽

Factor C ◽

Early Clinical Data with Small-Molecule Vascular Endothelial Growth Factor Tyrosine Kinase Receptor Inhibitors

Clinical Lung Cancer ◽

10.1016/s1525-7304(11)70204-2 ◽

2004 ◽

Vol 6 (2) ◽

pp. 74-76 ◽

Cited By ~ 2

Author(s):

G. Kesava Reddy ◽

Sakkaraiappan Ramalingam ◽

Vinay K. Jain

Keyword(s):

Growth Factor ◽

Tyrosine Kinase ◽

Small Molecule ◽

Clinical Data ◽

Tyrosine Kinase Receptor ◽

Vascular Endothelial ◽

Discovering Small Molecule Ligands of Vascular Endothelial Growth Factor That Block VEGF–KDR Binding Using Label-Free Microarray-Based Assays

Assay and Drug Development Technologies ◽

10.1089/adt.2012.485 ◽

2013 ◽

Vol 11 (5) ◽

pp. 326-332 ◽

Cited By ~ 21

Author(s):

James P. Landry ◽

Yiyan Fei ◽

Xiangdong Zhu ◽

Yaohuang Ke ◽

Guoliang Yu ◽

...

Keyword(s):

Growth Factor ◽

Small Molecule ◽

Vascular Endothelial ◽

Label Free ◽

Small Molecule Ligands ◽

Cyclooxygenase-2 expression in endometrial cancer: Correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylase

Human Pathology ◽

10.1053/hupa.2002.31292 ◽

2002 ◽

Vol 33 (2) ◽

pp. 213-219 ◽

Cited By ~ 79

Author(s):

Ritsuto Fujiwaki ◽

Kohji Iida ◽

Haruhiko Kanasaki ◽

Tomoya Ozaki ◽

Kohkichi Hata ◽

...

Keyword(s):

Endometrial Cancer ◽

Growth Factor ◽

Thymidine Phosphorylase ◽

Cyclooxygenase 2 ◽

Vascular Endothelial ◽

Microvessel Count ◽

Bevacizumab-enhanced antitumor effect of 5-fluorouracil via upregulation of thymidine phosphorylase through vascular endothelial growth factor A/vascular endothelial growth factor receptor 2-specificity protein 1 pathway

Cancer Science ◽

10.1111/cas.13779 ◽

2018 ◽

Vol 109 (10) ◽

pp. 3294-3304 ◽

Cited By ~ 10

Author(s):

Wenyue Liu ◽

Jingwei Zhang ◽

Xuequan Yao ◽

Chao Jiang ◽

Ping Ni ◽

...

Keyword(s):

Growth Factor ◽

Thymidine Phosphorylase ◽

Antitumor Effect ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Specificity Protein 1 ◽

Specificity Protein ◽