Androgen Deprivation Boosts Prostatic Infiltration of Cytotoxic and Regulatory T Lymphocytes and Has No Effect on Disease-Free Survival in Prostate Cancer Patients

2010 ◽  
Vol 17 (6) ◽  
pp. 1571-1581 ◽  
Author(s):  
Carlo Sorrentino ◽  
Piero Musiani ◽  
Paolo Pompa ◽  
Giuseppe Cipollone ◽  
Emma Di Carlo
Keyword(s):  
Prostate Cancer ◽  
T Lymphocytes ◽  
Cancer Patients ◽  
Disease Free Survival ◽  
Androgen Deprivation ◽  
Free Survival ◽  
Regulatory T Lymphocytes ◽  
Disease Free

scholarly journals Androgen Deprivation Therapy Combined With Particle Therapy for Prostate Cancer: A Systematic Review

2021 ◽  
Vol 11 ◽  
Author(s):  
Stine Elleberg Petersen ◽  
Morten Høyer
Keyword(s):  
Prostate Cancer ◽  
Systematic Review ◽  
High Risk ◽  
Androgen Deprivation Therapy ◽  
Disease Free Survival ◽  
Androgen Deprivation ◽  
Particle Therapy ◽  
Free Survival ◽  
High Risk Prostate Cancer ◽  
Disease Free

PurposeThere is high-level evidence for addition of androgen deprivation therapy to photon-based radiotherapy of the prostate in intermediate- and high-risk prostate cancer. Little is known about the value of ADT in particle therapy of prostate cancer. We are conducting a systematic review on biochemical disease-free survival, overall survival, and morbidity after combined particle therapy and ADT for prostate cancer.MethodsA thorough search in PubMed, Embase, Scopus, and Web of Science databases were conducted, searching for relevant studies. Clinical studies on prostate cancer and the treatment combination of particle therapy and androgen deprivation therapy were included. The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and registered on PROSPERO (CRD42021230801).ResultsA total of 298 papers were identified. Fifteen papers reporting on 7,202 patients after proton or carbon-ion therapy for localized prostate cancer where a fraction or all patients received ADT were selected for analysis. Three thousand five hundred and nineteen (49%) of the patients had received combined ADT and particle therapy. Primarily high-risk (87%), to a lesser extent intermediate-risk (34%) and low-risk patients (12%) received ADT. There were no comparative studies on the effect of ADT in patients treated with particles and no studies identified ADT as an independent prognostic factor related to survival outcomes.ConclusionsThe review found no evidence to support that the effects on biochemical disease-free survival and morbidity of combining ADT to particle therapy differs from the ADT effects in conventional photon based radiotherapy. The available data on the topic is limited.

Duration of neoadjuvant androgen deprivation therapy before radical prostatectomy and disease-free survival in men with prostate cancer

Urology ◽  
2001 ◽  
Vol 58 (2) ◽  
pp. 71-77 ◽  
Author(s):  
François Meyer ◽  
Isabelle Bairati ◽  
Caroline Bédard ◽  
Louis Lacombe ◽  
Bernard Têtu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Androgen Deprivation Therapy ◽  
Disease Free Survival ◽  
Androgen Deprivation ◽  
Free Survival ◽  
Disease Free
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