Tadalafil Reduces Myeloid-Derived Suppressor Cells and Regulatory T Cells and Promotes Tumor Immunity in Patients with Head and Neck Squamous Cell Carcinoma

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-14-1711 ◽

2014 ◽

Vol 21 (1) ◽

pp. 39-48 ◽

Author(s):

Donald T. Weed ◽

Jennifer L. Vella ◽

Isildinha M. Reis ◽

Adriana C. De la fuente ◽

Carmen Gomez ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

T Cells ◽

Regulatory T Cells ◽

Cell Carcinoma ◽

Head And Neck ◽

Tumor Immunity ◽

Squamous Cell ◽

Suppressor Cells ◽

Neck Squamous Cell Carcinoma ◽

Myeloid Derived Suppressor Cells

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Faculty Opinions recommendation of Tadalafil reduces myeloid-derived suppressor cells and regulatory T cells and promotes tumor immunity in patients with head and neck squamous cell carcinoma.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.722185405.793522524 ◽

2016 ◽

Author(s):

David Potter

Keyword(s):

Squamous Cell Carcinoma ◽

T Cells ◽

Regulatory T Cells ◽

Cell Carcinoma ◽

Head And Neck ◽

Tumor Immunity ◽

Squamous Cell ◽

Suppressor Cells ◽

Neck Squamous Cell Carcinoma ◽

Myeloid Derived Suppressor Cells

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TIGIT/CD155 blockade enhances anti-PD-L1 therapy in head and neck squamous cell carcinoma by targeting myeloid-derived suppressor cells

Oral Oncology ◽

10.1016/j.oraloncology.2021.105472 ◽

2021 ◽

Vol 121 ◽

pp. 105472

Author(s):

Liang Mao ◽

Yao Xiao ◽

Qi-Chao Yang ◽

Shao-Chen Yang ◽

Lei-Lei Yang ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Suppressor Cells ◽

Neck Squamous Cell Carcinoma ◽

Myeloid Derived Suppressor Cells

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Human Head and Neck Squamous Cell Carcinoma–Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells

The Journal of Immunology ◽

10.4049/jimmunol.1501293 ◽

2016 ◽

Vol 196 (3) ◽

pp. 1419-1429 ◽

Author(s):

Rania H. Younis ◽

Kyu Lee Han ◽

Tonya J. Webb

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Suppressor Cells ◽

Neck Squamous Cell Carcinoma ◽

Myeloid Derived Suppressor Cells ◽

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Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma

Molecular Cancer ◽

10.1186/s12943-017-0665-0 ◽

2017 ◽

Vol 16 (1) ◽

Author(s):

Si-Rui Ma ◽

Wei-Wei Deng ◽

Jian-Feng Liu ◽

Liang Mao ◽

Guang-Tao Yu ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

T Cells ◽

Regulatory T Cells ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Cd8 T Cells ◽

Neck Squamous Cell Carcinoma ◽

A2a Receptor ◽

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P094 Phenotypic and Functional Profiles of Natural Regulatory T Cells in the Circulation of Patients With Head and Neck Squamous Cell Carcinoma

Archives of Otolaryngology - Head and Neck Surgery ◽

10.1001/archotol.132.8.883-c ◽

2006 ◽

Vol 132 (8) ◽

pp. 883 ◽

Author(s):

L. Strauss ◽

J. T. Johnson ◽

T. L. Whiteside

Keyword(s):

Squamous Cell Carcinoma ◽

T Cells ◽

Regulatory T Cells ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Neck Squamous Cell Carcinoma ◽

Functional Profiles

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Abstract 35: Chemo-radiotherapy induces tolerogenic STAT3 signaling in circulating myeloid-derived suppressor cells in patients with head and neck squamous cell carcinoma (HNSCC)

10.1158/1557-3265.aacrahns17-35 ◽

2017 ◽

Author(s):

Haejung Won ◽

Sagus Sampath ◽

Erminia Massarelli ◽

Ellie Maghami ◽

Marcin Kortylewski

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Suppressor Cells ◽

Neck Squamous Cell Carcinoma ◽

Myeloid Derived Suppressor Cells ◽

Stat3 Signaling

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CD45RA−Foxp3high regulatory T cells have a negative impact on the clinical outcome of head and neck squamous cell carcinoma

Cancer Immunology Immunotherapy ◽

10.1007/s00262-017-2021-z ◽

2017 ◽

Vol 66 (10) ◽

pp. 1275-1285 ◽

Author(s):

Fumie Ihara ◽

Daiju Sakurai ◽

Atsushi Horinaka ◽

Yuji Makita ◽

Akira Fujikawa ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

T Cells ◽

Regulatory T Cells ◽

Clinical Outcome ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Negative Impact ◽

Neck Squamous Cell Carcinoma

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Myeloid derived suppressor cells but not regulatory T cells are associated with adaptive immunity and clinical outcomes in anal squamous cell carcinoma

Annals of Oncology ◽

10.1093/annonc/mdz268.030 ◽

2019 ◽

Vol 30 ◽

pp. v770-v771 ◽

Author(s):

C. Borg ◽

L. Spehner ◽

M. Kroemer ◽

S. Kim ◽

M. Jary ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

T Cells ◽

Regulatory T Cells ◽

Cell Carcinoma ◽

Clinical Outcomes ◽

Adaptive Immunity ◽

Squamous Cell ◽

Suppressor Cells ◽

Myeloid Derived Suppressor Cells ◽

Anal Squamous Cell Carcinoma

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895P Disproportional enrichment of FoxP3+CD4+ regulatory T-cells shapes a suppressive tumor microenvironment and provokes anti–PD-1 resistance in head and neck squamous cell carcinoma

Annals of Oncology ◽

10.1016/j.annonc.2021.08.1305 ◽

2021 ◽

Vol 32 ◽

pp. S800

Author(s):

C.G. Kim ◽

S. Park ◽

D.H. Kim ◽

M.H. Hong ◽

E.C. Choi ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

T Cells ◽

Tumor Microenvironment ◽

Regulatory T Cells ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Neck Squamous Cell Carcinoma

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P102 Induction of IL-10+ Tr1-Like Regulatory T Cells in the Microenvironment of COX-2+ Head and Neck Squamous Cell Carcinoma

Archives of Otolaryngology - Head and Neck Surgery ◽

10.1001/archotol.132.8.885-c ◽

2006 ◽

Vol 132 (8) ◽

pp. 885 ◽

Author(s):

C. Bergmann ◽

L. Strauss ◽

S. Lang ◽

R. Zeidler ◽

T. L. Whiteside

Keyword(s):

Squamous Cell Carcinoma ◽

T Cells ◽

Regulatory T Cells ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Neck Squamous Cell Carcinoma ◽

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