Abstract P078: Aurora A kinase inhibition with VIC-1911 overcomes intrinsic and acquired resistance to KRASG12C inhibition in KRAS(G12C)-mutated lung cancer

2021 ◽  
Author(s):  
Jong Woo Lee ◽  
Sundong Kim ◽  
Cindy Yang ◽  
Barbara Burtness
Keyword(s):  
Lung Cancer ◽  
Acquired Resistance ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Kinase Inhibition

scholarly journals Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death

2019 ◽  
Vol 80 (4) ◽  
pp. 832-842 ◽  
Author(s):  
Johannes Ommer ◽  
Joanna L. Selfe ◽  
Marco Wachtel ◽  
Eleanor M. O'Brien ◽  
Dominik Laubscher ◽  
...  
Keyword(s):  
Cell Death ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Kinase Inhibition ◽  
Rhabdomyosarcoma Cell

scholarly journals Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation

Oncotarget ◽  
2017 ◽  
Vol 8 (11) ◽  
pp. 17412-17427 ◽  
Author(s):  
Mark A. Currier ◽  
Les Sprague ◽  
Tilat A. Rizvi ◽  
Brooke Nartker ◽  
Chun-Yu Chen ◽  
...  
Keyword(s):  
Immune Modulation ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Kinase Inhibition ◽  
Cellular Immune

Abstract 4242: Effects of dual inhibition of EGFR and Aurora A kinase in a lung cancer model

2014 ◽  
Author(s):  
Tetyana Bagnyukova ◽  
Xiaofan Pan ◽  
Jiping Zhang ◽  
Brian Egleston ◽  
Igor Astsaturov ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Cancer Model ◽  
Lung Cancer Model ◽  
Dual Inhibition

scholarly journals 666. Oncolytic Herpes Virotherapy Induces a Paracrine Death Signal Causing Synergistic Antitumor Efficacy with Aurora A Kinase Inhibition

2016 ◽  
Vol 24 ◽  
pp. S263-S264
Author(s):  
Leslee Sprague ◽  
Mark Currier ◽  
Tilat Rizvi ◽  
Brooke Nartker ◽  
Chun-Yu Chen ◽  
...  
Keyword(s):  
Antitumor Efficacy ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Kinase Inhibition

Aurora-A kinase inhibition enhances the cytosine arabinoside-induced cell death in leukemia cells through apoptosis and mitotic catastrophe

2010 ◽  
Vol 297 (2) ◽  
pp. 171-181 ◽  
Author(s):  
June-Won Cheong ◽  
Haeng-Im Jung ◽  
Ju In Eom ◽  
Soo Jung Kim ◽  
Hoi-Kyung Jeung ◽  
...  
Keyword(s):  
Cell Death ◽  
Cytosine Arabinoside ◽  
Leukemia Cells ◽  
Mitotic Catastrophe ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Kinase Inhibition

scholarly journals Overcoming CML acquired resistance by specific inhibition of Aurora A kinase in the KCL-22 cell model

2011 ◽  
Vol 33 (2) ◽  
pp. 285-293 ◽  
Author(s):  
Hongfeng Yuan ◽  
Zhiqiang Wang ◽  
Hao Zhang ◽  
Mendel Roth ◽  
Ravi Bhatia ◽  
...  
Keyword(s):  
Cell Model ◽  
Acquired Resistance ◽  
Specific Inhibition ◽  
Aurora A Kinase ◽  
Aurora A

398 TAS-119 a selective inhibitor of Aurora A kinase, potentiates taxane therapy in breast and lung cancer models

2014 ◽  
Vol 50 ◽  
pp. 127-128
Author(s):  
Y. Nakatsuru ◽  
A. Hashimoto ◽  
H. Sootome ◽  
K. Ito ◽  
M. Sakuragi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Selective Inhibitor ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Cancer Models
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