Abstract P209: Collaborative crosstalk between two apoptosis pathways drives synergy of dual inhibition of BCL-2/MDM2 in preclinical models of neuroblastoma

2021 ◽  
Author(s):  
Douglas D. Fang ◽  
Qiuqiong Tang ◽  
Qixin Wang ◽  
Yanhui Kong ◽  
Na Li ◽  
...  
Keyword(s):  
Preclinical Models ◽  
Apoptosis Pathways ◽  
Dual Inhibition

scholarly journals Dual Inhibition of IGF-1R and ErbB3 Enhances the Activity of Gemcitabine and Nab-Paclitaxel in Preclinical Models of Pancreatic Cancer

2018 ◽  
Vol 24 (12) ◽  
pp. 2873-2885 ◽  
Author(s):  
Adam J. Camblin ◽  
Emily A. Pace ◽  
Sharlene Adams ◽  
Michael D. Curley ◽  
Victoria Rimkunas ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Preclinical Models ◽  
Dual Inhibition

Dual inhibition of the PI3K and MAPK pathways enhances nab-paclitaxel/gemcitabine chemotherapy response in preclinical models of pancreatic cancer

2019 ◽  
Vol 459 ◽  
pp. 41-49 ◽  
Author(s):  
Niranjan Awasthi ◽  
David Kronenberger ◽  
Alexis Stefaniak ◽  
Md Sazzad Hassan ◽  
Urs von Holzen ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Chemotherapy Response ◽  
Preclinical Models ◽  
Mapk Pathways ◽  
Dual Inhibition

Molecular Mechanism of Apoptosis Induction by Resveratrol, a Natural Cancer Chemopreventive Agent

2008 ◽  
Vol 78 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Fan ◽  
Jiang ◽  
Zhang ◽  
Bai
Keyword(s):  
Cancer Treatment ◽  
Molecular Mechanism ◽  
Apoptosis Induction ◽  
Protective Agents ◽  
Chemopreventive Agent ◽  
Naturally Occurring ◽  
Apoptosis Pathways ◽  
Present Understanding

In efforts to identify naturally occurring compounds that act as protective agents, resveratrol, a phytoalexin existing in wine, has attracted much interest because of its diverse pharmacological characteristics. Considering that apoptosis induction is the most potent defense approach for cancer treatment, we have tried to summarize our present understanding of apoptosis induction by resveratrol based on the two major apoptosis pathways.

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