Abstract 2083: The stress oncoprotein LEDGF/p75 attenuates oxidative stress-induced necrosis but not apoptosis in prostate cancer cells

Author(s):  
Lai Sum Leoh ◽  
Melanie Mediavilla-Varela ◽  
Anamika Basu ◽  
Tracy R. Daniels ◽  
Shannalee Martinez ◽  
...  
2008 ◽  
Vol 179 (4S) ◽  
pp. 192-193 ◽  
Author(s):  
Binod Kumar ◽  
Sweaty Koul ◽  
Lakshmipathi Khandrika ◽  
Randall B Meacham ◽  
Hari K Koul

2010 ◽  
Vol 70 (11) ◽  
pp. 4560-4568 ◽  
Author(s):  
Farideh Mehraein-Ghomi ◽  
Hirak S. Basu ◽  
Dawn R. Church ◽  
F. Michael Hoffmann ◽  
George Wilding

The Prostate ◽  
2011 ◽  
Vol 72 (6) ◽  
pp. 612-625 ◽  
Author(s):  
Alexandra M. Fajardo ◽  
Debra A. MacKenzie ◽  
Ming Ji ◽  
Lorraine M. Deck ◽  
David L. Vander Jagt ◽  
...  

Toxins ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 199 ◽  
Author(s):  
Karolina Kowalska ◽  
Dominika Ewa Habrowska-Górczyńska ◽  
Kamila Domińska ◽  
Kinga Anna Urbanek ◽  
Agnieszka Wanda Piastowska-Ciesielska

Nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) is commonly expressed in prostate cancer (PCa) cells and is associated with increased proliferation, metastases and androgen independence. Zearalenone (ZEA) is one of the most common mycotoxins contaminating food, which might mimic estrogens and bind to estrogen receptors (ERs). The ratio of androgens to estrogens in men decreases physiologically with age, and is believed to participate in prostate carcinogenesis. In this study, we evaluated the role of NFκB and ERβ in the induction of oxidative stress in human PCa cells by ZEA. As observed, ZEA at a dose of 30 µM induces oxidative stress in PCa cells associated with DNA damage and G2/M cell cycle arrest. We also observed that the inhibition of ERβ and NFΚB via specific inhibitors (PHTPP and BAY 117082) significantly increased ZEA-induced oxidative stress, although the mechanism seems to be different for androgen-dependent and androgen-independent cells. Based on our findings, it is possible that the activation of ERβ and NFΚB in PCa might protect cancer cells from ZEA-induced oxidative stress. We therefore shed new light on the mechanism of ZEA toxicity in human cells.


2009 ◽  
Vol 13 (1) ◽  
pp. 39-46 ◽  
Author(s):  
J P Lu ◽  
L Monardo ◽  
I Bryskin ◽  
Z F Hou ◽  
J Trachtenberg ◽  
...  

2012 ◽  
Vol 132 (10) ◽  
pp. 2270-2282 ◽  
Author(s):  
Baoyi Zhu ◽  
Xiaojuan Li ◽  
Yuying Zhang ◽  
Chunwei Ye ◽  
Yu Wang ◽  
...  

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Menna El Gafaary ◽  
Berthold Büchele ◽  
Tatiana Syrovets ◽  
Christoph Schmidt ◽  
Thomas Simmet

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