Abstract 2548: Quantitative changes in endogenous DNA adducts correlate with conazole mutagenicity and tumorigenicity in mouse liver

2012 ◽  
Author(s):  
Jeffrey A. Ross ◽  
Sharon A. Leavitt ◽  
Judith E. Schmid ◽  
Garret B. Nelson
Keyword(s):  
Dna Adducts ◽  
Mouse Liver ◽  
Quantitative Changes

Effect of Dietary Restriction and Age on the Formation of DNA Adducts from the Mouse liver Microsome-Mediated Metabolism of 2-Nitropyrene

2000 ◽  
Vol 16 (1-4) ◽  
pp. 151-159
Author(s):  
Diogenes Herreno-saenz ◽  
Linda S. Von tungeln ◽  
Ronald W. Hart ◽  
Peter P. Fu
Keyword(s):  
Dna Adducts ◽  
Dietary Restriction ◽  
Mouse Liver ◽  
Liver Microsome

Formation of C8-modified deoxyguanosine and C8-modified deoxyadenosine as major DNA adducts from 2-nitropyrene metabolism mediated by rat and mouse liver microsomes and cytosols

1991 ◽  
Vol 12 (4) ◽  
pp. 609-616 ◽  
Author(s):  
Peter P. Fu ◽  
Dwight W. Miller ◽  
Linda S. Von Tungeln ◽  
Matthew S. Bryant ◽  
Jackson O. Lay ◽  
...  
Keyword(s):  
Dna Adducts ◽  
Mouse Liver ◽  
Liver Microsomes

scholarly journals Dietary curcumin post-treatment enhances the disappearance of B(a)P-derived DNA adducts in mouse liver and lungs

2014 ◽  
Vol 1 ◽  
pp. 1181-1194 ◽  
Author(s):  
Gaurav Kumar ◽  
Pooja Tajpara ◽  
Amirali B. Bukhari ◽  
Asha G. Ramchandani ◽  
Abhijit De ◽  
...  
Keyword(s):  
Dna Adducts ◽  
Mouse Liver ◽  
Post Treatment

The Capacity of Murine Epithelial Cell Lines with Different Degrees of Malignant Transformation to Metabolise Benzo[a]pyrene

1996 ◽  
Vol 24 (4) ◽  
pp. 541-546
Author(s):  
Cristina Viezzer ◽  
Roberto Revoltella ◽  
Lucia Celotti
Keyword(s):  
Epithelial Cell ◽  
Malignant Transformation ◽  
Cell Lines ◽  
Dna Adducts ◽  
Active Metabolite ◽  
Mouse Liver ◽  
Fetal Mouse ◽  
Murine Cell ◽  
Epithelial Cell Lines ◽  
Fetal Mouse Liver

Cultures of three murine cell lines derived from fetal mouse liver (FL, FLT3 and FLT5) were treated with benzo[a]pyrene to evaluate their ability to activate promutagens. DNA adducts were detected in all three cell lines when they were treated with the major active metabolite of benzo[a]pyrene, benzo[a]pyrene diolepoxide. DNA adducts were also produced in FL and FLT3 cells when they were treated with the promutagen, benzo[a]pyrene, while treatment of FLT5 cells resulted in very few DNA adducts. In treated FL and FLT3 cells, the most evident adduct spot detected showed a chromatographic position similar to that of the main adduct formed in cells treated with (±)-r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydro-benzo[a]pyrene.

Formation and persistence of safrole-DNA adducts over a 10 000-fold dose range in mouse liver

1993 ◽  
Vol 14 (8) ◽  
pp. 1517-1521 ◽  
Author(s):  
Krishna P. Gupta ◽  
Kenneth L. van Golen ◽  
Kim L. Putman ◽  
Kurt Randerath
Keyword(s):  
Dna Adducts ◽  
Mouse Liver ◽  
Dose Range

scholarly journals Quantitative changes in endogenous DNA adducts correlate with conazole in vivo mutagenicity and tumorigenicity

Mutagenesis ◽  
2012 ◽  
Vol 27 (5) ◽  
pp. 541-549 ◽  
Author(s):  
J. A. Ross ◽  
S. A. Leavitt ◽  
J. E. Schmid ◽  
G. B. Nelson
Keyword(s):  
Dna Adducts ◽  
In Vivo Mutagenicity ◽  
Quantitative Changes

scholarly journals Quantitative Changes in Mouse Liver Ultrastructure Following Cortisone and Insulin Administration

1969 ◽  
Vol 22 (4) ◽  
pp. 965 ◽  
Author(s):  
Pamela J Bmchmeier
Keyword(s):  
Mouse Liver ◽  
Volume Fraction ◽  
Linear Analysis ◽  
Objective Method ◽  
Insulin Administration ◽  
Cytoplasmic Matrix ◽  
Shape Coefficient ◽  
Quantitative Changes ◽  
Mitochondrial Number ◽  
Parenchymal Cells

Linear analysis of whole cell montages provided the basis for determining the following in mouse liver parenchymal cells: the cytoplasmic volume fraction of mitochondria, lysosomes, lipid, glycogen, and cytoplasmic matrix; the membrane profile concentration; and mitochondrial number and dimensions (including a shape coefficient). Included are a number of studies of the validity of the methods used, some new statistical considerations, and a new, more objective method of determining mitochondrial shape.

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