Abstract 4635: The LSD1 Specific Inhibitor INCB059872 enhances the activity of immune checkpoint blockade by reshaping the myeloid compartment in the syngeneic 4T1 mouse mammary tumor model

2017 ◽  
Author(s):  
Thomas Condamine ◽  
Steve Wang ◽  
Melody Diamond ◽  
Leslie Hall ◽  
Huiqing Liu ◽  
...  
Keyword(s):  
Mammary Tumor ◽  
Immune Checkpoint ◽  
Specific Inhibitor ◽  
Tumor Model ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade ◽  
Mouse Mammary Tumor ◽  
Mammary Tumor Model ◽  
Mouse Mammary Tumor Model

scholarly journals Assessment of the WAP-Myc mouse mammary tumor model for spontaneous metastasis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Begüm Utz ◽  
Rita Turpin ◽  
Johanna Lampe ◽  
Jeroen Pouwels ◽  
Juha Klefström
Keyword(s):  
Breast Cancer ◽  
Mammary Tumor ◽  
Tumor Model ◽  
Primary Tumors ◽  
T Cell Infiltration ◽  
Cancer Models ◽  
Mouse Mammary Tumor ◽  
Mammary Tumor Model ◽  
Metastatic Process ◽  
Mouse Mammary Tumor Model

Abstract Breast cancer is the most common form of cancer in women. Despite significant therapeutic advances in recent years, breast cancer also still causes the greatest number of cancer-related deaths in women, the vast majority of which (> 90%) are caused by metastases. However, very few mouse mammary cancer models exist that faithfully recapitulate the multistep metastatic process in human patients. Here we assessed the suitability of a syngrafting protocol for a Myc-driven mammary tumor model (WAP-Myc) to study autochthonous metastasis. A moderate but robust spontaneous lung metastasis rate of around 25% was attained. In addition, increased T cell infiltration was observed in metastatic tumors compared to donor and syngrafted primary tumors. Thus, the WAP-Myc syngrafting protocol is a suitable tool to study the mechanisms of metastasis in MYC-driven breast cancer.

scholarly journals T-cadherin Supports Angiogenesis and Adiponectin Association with the Vasculature in a Mouse Mammary Tumor Model

2008 ◽  
Vol 68 (5) ◽  
pp. 1407-1416 ◽  
Author(s):  
Lionel W. Hebbard ◽  
Michèle Garlatti ◽  
Lawrence J.T. Young ◽  
Robert D. Cardiff ◽  
Robert G. Oshima ◽  
...  
Keyword(s):  
Mammary Tumor ◽  
Tumor Model ◽  
Mouse Mammary Tumor ◽  
Mammary Tumor Model ◽  
Mouse Mammary Tumor Model

scholarly journals Wnt signaling can substitute for estrogen to induce division of ERα-positive cells in a mouse mammary tumor model

2010 ◽  
Vol 289 (1) ◽  
pp. 23-31 ◽  
Author(s):  
Melissa Mastroianni ◽  
Soyoung Kim ◽  
Young Chul Kim ◽  
Amanda Esch ◽  
Caroline Wagner ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Mammary Tumor ◽  
Tumor Model ◽  
Mouse Mammary Tumor ◽  
Mammary Tumor Model ◽  
Mouse Mammary Tumor Model

Antiapoptotic Small Interfering RNA as Potent Adjuvant of DNA Vaccination in a Mouse Mammary Tumor Model

2009 ◽  
Vol 20 (6) ◽  
pp. 589-597 ◽  
Author(s):  
Sridhar Dharmapuri ◽  
Luigi Aurisicchio ◽  
Antonella Biondo ◽  
Natalie Welsh ◽  
Gennaro Ciliberto ◽  
...  
Keyword(s):  
Mammary Tumor ◽  
Small Interfering Rna ◽  
Tumor Model ◽  
Dna Vaccination ◽  
Mouse Mammary Tumor ◽  
Mammary Tumor Model ◽  
Interfering Rna ◽  
Mouse Mammary Tumor Model

scholarly journals Jnk2 Effects on Tumor Development, Genetic Instability and Replicative Stress in an Oncogene-Driven Mouse Mammary Tumor Model

PLoS ONE ◽  
2010 ◽  
Vol 5 (5) ◽  
pp. e10443 ◽  
Author(s):  
Peila Chen ◽  
Jamye F. O'Neal ◽  
Nancy D. Ebelt ◽  
Michael A. Cantrell ◽  
Shreya Mitra ◽  
...  
Keyword(s):  
Mammary Tumor ◽  
Genetic Instability ◽  
Tumor Development ◽  
Tumor Model ◽  
Replicative Stress ◽  
Mouse Mammary Tumor ◽  
Mammary Tumor Model ◽  
Mouse Mammary Tumor Model
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