scholarly journals Abstract 4916: E3 ubiquitin ligase Cbl-b prevents tumor metastasis by maintaining the epithelial phenotype in multiple drug-resistant gastric and breast cancer cells

2017 ◽  
Author(s):  
Ling Xu ◽  
Xiujuan Qu ◽  
Ye Zhang ◽  
Xiaofang Che ◽  
Tianshu Guo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Ubiquitin Ligase ◽  
Breast Cancer Cells ◽  
Tumor Metastasis ◽  
E3 Ubiquitin Ligase ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Multiple Drug Resistant ◽  
Epithelial Phenotype

scholarly journals The E3 ubiquitin ligase Cbl-b inhibits tumor growth in multidrug-resistant gastric and breast cancer cells

Neoplasma ◽  
2017 ◽  
Vol 64 (06) ◽  
pp. 887-892 ◽  
Author(s):  
X. CHe ◽  
Y. Zhang ◽  
X. Qu ◽  
T. Guo ◽  
Y. Ma ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Ubiquitin Ligase ◽  
Breast Cancer Cells ◽  
E3 Ubiquitin Ligase ◽  
Multidrug Resistant

scholarly journals Targeting β-Transducin Repeat–Containing Protein E3 Ubiquitin Ligase Augments the Effects of Antitumor Drugs on Breast Cancer Cells

2005 ◽  
Vol 65 (5) ◽  
pp. 1904-1908 ◽  
Author(s):  
Weigang Tang ◽  
Ying Li ◽  
Duonan Yu ◽  
Andrei Thomas-Tikhonenko ◽  
Vladimir S. Spiegelman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Ubiquitin Ligase ◽  
Breast Cancer Cells ◽  
E3 Ubiquitin Ligase ◽  
Antitumor Drugs

scholarly journals JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yanlin Ren ◽  
Dongyin Chen ◽  
Zurong Zhai ◽  
Junjie Chen ◽  
Aiping Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Ubiquitin Ligase ◽  
Breast Cancer Cells ◽  
E3 Ubiquitin Ligase ◽  
Her2 Positive ◽  
Her2 Positive Breast Cancer ◽  
Positive Breast Cancer

AbstractThe overexpression of HER2 is associated with a malignant proliferation of breast cancer. In this study, we developed a non-cytotoxic JWA gene activating compound 1 (JAC1) to inhibit the proliferation of HER2-positive breast cancer cells in vitro and in vivo experimental models. JAC1 increased the ubiquitination of HER2 at the K716 site through the E3 ubiquitin ligase SMURF1 which was due to the decreased expression of NEDD4, the E3 ubiquitin ligase of SMURF1. In conclusion, JAC1 suppresses the proliferation of HER2-positive breast cancer cells through the JWA triggered HER2 ubiquitination signaling. JAC1 may serve as a potential therapeutic agent for HER2-positive breast cancer.

scholarly journals Smurf2 E3 ubiquitin ligase modulates proliferation and invasiveness of breast cancer cells in a CNKSR2 dependent manner

Cell Division ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. 2 ◽  
Author(s):  
Diana David ◽  
Sankar Jagadeeshan ◽  
Ramkumar Hariharan ◽  
Asha Nair ◽  
Radhakrishna Pillai
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Ubiquitin Ligase ◽  
Breast Cancer Cells ◽  
E3 Ubiquitin Ligase ◽  
Dependent Manner
Sign in / Sign up

Export Citation Format

Share Document