Abstract 1277: Honokiol, a natural product, overcomes acquired resistance of EGFR mutant NSCLC cells to the third generation EGFR inhibitor, osimertinib

2019 ◽  
Author(s):  
Hongjing ZANG ◽  
Songqing Fan ◽  
Jack Arbiser ◽  
Taofeek K. Owonikoko ◽  
Suresh S. Ramalingam ◽  
...  
Keyword(s):  
Natural Product ◽  
Acquired Resistance ◽  
Third Generation ◽  
Egfr Inhibitor ◽  
The Third ◽  
Egfr Mutant

scholarly journals Overcoming acquired resistance of EGFR‐mutant NSCLC cells to the third generation EGFR inhibitor, osimertinib, with the natural product honokiol

2020 ◽  
Vol 14 (4) ◽  
pp. 882-895 ◽  
Author(s):  
Hongjing Zang ◽  
Guoqing Qian ◽  
Jack Arbiser ◽  
Taofeek K. Owonikoko ◽  
Suresh S. Ramalingam ◽  
...  
Keyword(s):  
Natural Product ◽  
Acquired Resistance ◽  
Third Generation ◽  
Egfr Inhibitor ◽  
The Third ◽  
Egfr Mutant

scholarly journals Inhibition of ACK1 delays and overcomes acquired resistance of EGFR mutant NSCLC cells to the third generation EGFR inhibitor, osimertinib

Lung Cancer ◽  
2020 ◽  
Vol 150 ◽  
pp. 26-35
Author(s):  
Jiajia Gu ◽  
Luxi Qian ◽  
Guojing Zhang ◽  
Nupam P. Mahajan ◽  
Taofeek K. Owonikoko ◽  
...  
Keyword(s):  
Acquired Resistance ◽  
Third Generation ◽  
Egfr Inhibitor ◽  
The Third ◽  
Egfr Mutant

scholarly journals MET or NRAS amplification is an acquired resistance mechanism to the third-generation EGFR inhibitor naquotinib

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Kiichiro Ninomiya ◽  
Kadoaki Ohashi ◽  
Go Makimoto ◽  
Shuta Tomida ◽  
Hisao Higo ◽  
...  
Keyword(s):  
Acquired Resistance ◽  
Resistance Mechanism ◽  
Third Generation ◽  
Egfr Inhibitor ◽  
The Third
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