Abstract 1494: IgE receptor-activated human mast cells have potent anti-cancer properties

2021 ◽  
Author(s):  
Chris Kepley ◽  
Mohammad Ferrydouni ◽  
Mona Motaghed ◽  
Kristen Dellinger
Keyword(s):  
Mast Cells ◽  
Ige Receptor ◽  
Human Mast Cells ◽  
Anti Cancer

scholarly journals Killer Immunoglobulin-Like Receptor 2DL4 (CD158d) Regulates Human Mast Cells Both Positively and Negatively: Possible Roles in Pregnancy and Cancer Metastasis

2019 ◽  
Author(s):  
Tatsuki R. Kataoka ◽  
Chiyuki Ueshima ◽  
Masahiro Hirata ◽  
Sachiko Minamiguchi ◽  
Hironori Haga
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Cancer Metastasis ◽  
Nk Cell ◽  
Human Leukocyte ◽  
Human Mast Cell ◽  
Allergic Reactions ◽  
Ige Receptor ◽  
Human Mast Cells ◽  
In Pregnancy

Killer immunoglobulin-like receptor (KIR) 2DL4 (CD158d) was previously thought to be a human NK-cell-specific protein but its expression has also been demonstrated in human mast cells. Mast cells are involved in allergic reactions via their KIT-mediated and IgE receptor-mediated responses. We recently detected the expression of KIR2DL4 in human cultured mast cells established from peripheral blood derived from healthy volunteers (PB-mast), a human mast cell line (LAD2), and non-neoplastic mast cells, including pathological specimens. An agonistic antibody against KIR2DL4 negatively regulates the KIT- and IgE-receptor-mediated responses of PB-mast and LAD2 cells. In addition, agonistic antibodies and human leukocyte antigen (HLA)-G, a natural ligand for KIR2DL4, induce the secretion from these cells of leukemia inhibitory factor and serine proteases, which have been implicated in pregnancy establishment and cancer metastasis. Therefore, KIR2DL4 stimulation with agonistic antibodies and recombinant HLA-G protein may enhance both processes, in addition to suppressing mast-cell-mediated allergic reactions.

scholarly journals High-affinity IgE receptor-β chain expression in human mast cells

2008 ◽  
Vol 336 (2) ◽  
pp. 229-234 ◽  
Author(s):  
Akira Matsuda ◽  
Yoshimichi Okayama ◽  
Nobuyuki Ebihara ◽  
Norihiko Yokoi ◽  
Peisong Gao ◽  
...  
Keyword(s):  
Mast Cells ◽  
Ige Receptor ◽  
High Affinity ◽  
Human Mast Cells ◽  
High Affinity Ige Receptor ◽  
Β Chain

scholarly journals Substance P downregulates expression of the high affinity IgE receptor (FcεRI) by human mast cells

2010 ◽  
Vol 220 (1-2) ◽  
pp. 17-24 ◽  
Author(s):  
Christine McCary ◽  
Brian P. Tancowny ◽  
Adriana Catalli ◽  
Leslie C. Grammer ◽  
Kathleen E. Harris ◽  
...  
Keyword(s):  
Mast Cells ◽  
Substance P ◽  
Ige Receptor ◽  
High Affinity ◽  
Human Mast Cells ◽  
High Affinity Ige Receptor

Il-4 Induces The Expression of The Low Affinity IgE Receptor (CD23) on Human Mast Cells

2008 ◽  
Vol 121 (2) ◽  
pp. S15-S15 ◽  
Author(s):  
E SWARTZ ◽  
S MATSUMURA ◽  
Y HAN ◽  
A GIBBONS ◽  
F HSIEH
Keyword(s):  
Mast Cells ◽  
Ige Receptor ◽  
Human Mast Cells

Cultured Human Mast Cells Are Heterogeneous for Expression of the High-Affinity IgE Receptor FcεRI

2012 ◽  
Vol 157 (3) ◽  
pp. 246-250 ◽  
Author(s):  
Hans Jürgen Hoffmann ◽  
Pernille Munk Frandsen ◽  
Lars Harder Christensen ◽  
Peter Oluf Schiøtz ◽  
Ronald Dahl
Keyword(s):  
Mast Cells ◽  
Ige Receptor ◽  
High Affinity ◽  
Human Mast Cells ◽  
High Affinity Ige Receptor

scholarly journals Induction of the high-affinity IgE receptor (FcɛRI) on human mast cells by IL-4

1996 ◽  
Vol 8 (9) ◽  
pp. 1367-1373 ◽  
Author(s):  
Hano Toru, Chisel Ra ◽  
Shigeaki Nonoyama ◽  
Katsuhiro Suzuki ◽  
Jun-ichi Yata ◽  
Tatsutoshi Nakahata ◽  
...  
Keyword(s):  
Mast Cells ◽  
Ige Receptor ◽  
High Affinity ◽  
Human Mast Cells ◽  
High Affinity Ige Receptor

scholarly journals Gangliosides enhance IgE receptor-dependent histamine and LTC4 release from human mast cells

1995 ◽  
Vol 1269 (1) ◽  
pp. 79-84 ◽  
Author(s):  
Torsten Zuberbier ◽  
Christine Pfrommer ◽  
Jacqueline Beinhölzl ◽  
Karin Hartmann ◽  
Jörg Ricklinkat ◽  
...  
Keyword(s):  
Mast Cells ◽  
Ige Receptor ◽  
Human Mast Cells
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