Abstract A015: Molecular tumor profiling to identify mechanisms linking statin use with lower risk of lethal prostate cancer: Results from the Health Professionals Follow-up Study

PURPOSE It is unknown whether alcohol intake is associated with the risk of lethal (metastatic or fatal) prostate cancer. We examine (1) whether alcohol intake among men at risk of prostate cancer is associated with diagnosis of lethal prostate cancer and (2) whether intake among men with nonmetastatic prostate cancer is associated with metastasis or death. METHODS This prospective cohort study uses the Health Professionals Follow-Up Study (1986 to 2012). Our analysis of alcohol intake among men at risk of prostate cancer included 47,568 cancer-free men. Our analysis of alcohol intake among men with prostate cancer was restricted to 5,182 men diagnosed with nonmetastatic prostate cancer during follow-up. We examine the association of total alcohol, red and white wine, beer, and liquor with lethal prostate cancer and death. Multivariate Cox proportional hazards regression estimated hazard ratios (HRs) and 95% CIs. RESULTS Alcohol drinkers had a lower risk of lethal prostate cancer (any v none: HR, 0.84 [95% CI, 0.71 to 0.99]) without a dose-response relationship. Total alcohol intake among patients with prostate cancer was not associated with progression to lethal prostate cancer (any v none: HR, 0.99 [95% CI, 0.57 to 1.72]), whereas moderate red wine intake was associated with a lower risk (any v none: HR, 0.50 [95% CI, 0.29 to 0.86]; P trend = .05). Compared with none, 15 to 30 g/d of total alcohol after prostate cancer diagnosis was associated with a lower risk of death (HR, 0.71 [95% CI, 0.50 to 1.00]), as was red wine (any v none: HR, 0.74 [95% CI, 0.57 to 0.97]; P trend = .007). CONCLUSION Cancer-free men who consumed alcohol had a slightly lower risk of lethal prostate cancer compared with abstainers. Among men with prostate cancer, red wine was associated with a lower risk of progression to lethal disease. These observed associations merit additional study but provide assurance that moderate alcohol consumption is safe for patients with prostate cancer.

Download Full-text

Postdiagnostic Statin Use and the Risk of Lethal Prostate Cancer in the Health Professionals Follow-up Study

Cancer Epidemiology Biomarkers & Prevention ◽

10.1158/1055-9965.epi-15-0671 ◽

2015 ◽

Vol 24 (10) ◽

pp. 1638-1640 ◽

Cited By ~ 6

Author(s):

June M. Chan ◽

Stacey A. Kenfield ◽

Alan Paciorek ◽

Elizabeth A. Platz ◽

Edward L. Giovannucci ◽

...

Keyword(s):

Prostate Cancer ◽

Health Professionals ◽

Follow Up Study ◽

Statin Use ◽

Lethal Prostate Cancer

Download Full-text

Asthma and risk of lethal prostate cancer in the Health Professionals Follow-Up Study

International Journal of Cancer ◽

10.1002/ijc.29463 ◽

2015 ◽

Vol 137 (4) ◽

pp. 949-958 ◽

Cited By ~ 13

Author(s):

Elizabeth A. Platz ◽

Charles G. Drake ◽

Kathryn M. Wilson ◽

Siobhan Sutcliffe ◽

Stacey A. Kenfield ◽

...

Keyword(s):

Prostate Cancer ◽

Health Professionals ◽

Follow Up Study ◽

Lethal Prostate Cancer

Download Full-text

Aspirin Use and Lethal Prostate Cancer in the Health Professionals Follow-up Study

European Urology Oncology ◽

10.1016/j.euo.2018.07.002 ◽

2019 ◽

Vol 2 (2) ◽

pp. 126-134 ◽

Cited By ~ 1

Author(s):

Mary K. Downer ◽

Christopher B. Allard ◽

Mark A. Preston ◽

Kathryn M. Wilson ◽

Stacey A. Kenfield ◽

...

Keyword(s):

Prostate Cancer ◽

Health Professionals ◽

Follow Up Study ◽

Lethal Prostate Cancer

Download Full-text

Faculty Opinions recommendation of Alcohol Intake and Risk of Lethal Prostate Cancer in the Health Professionals Follow-Up Study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.735618127.793561502 ◽

2019 ◽

Author(s):

Eva Chalas

Keyword(s):

Prostate Cancer ◽

Health Professionals ◽

Alcohol Intake ◽

Follow Up Study ◽

Lethal Prostate Cancer

Download Full-text

Re: Alcohol Intake and Risk of Lethal Prostate Cancer in the Health Professionals Follow-Up Study

The Journal of Urology ◽

10.1097/01.ju.0000585748.03815.d6 ◽

2019 ◽

Vol 202 (6) ◽

pp. 1100-1098

Author(s):

Samir S. Taneja

Keyword(s):

Prostate Cancer ◽

Health Professionals ◽

Alcohol Intake ◽

Follow Up Study ◽

Lethal Prostate Cancer

Download Full-text

Physical Activity and Survival After Prostate Cancer Diagnosis in the Health Professionals Follow-Up Study

Journal of Clinical Oncology ◽

10.1200/jco.2010.31.5226 ◽

2011 ◽

Vol 29 (6) ◽

pp. 726-732 ◽

Cited By ~ 317

Author(s):

Stacey A. Kenfield ◽

Meir J. Stampfer ◽

Edward Giovannucci ◽

June M. Chan

Keyword(s):

Physical Activity ◽

Prostate Cancer ◽

Health Professionals ◽

Lower Risk ◽

Multivariable Analysis ◽

Vigorous Activity ◽

Follow Up Study ◽

All Cause Mortality ◽

Overall Mortality

Purpose To determine whether higher physical activity after prostate cancer (PCa) diagnosis decreases risk of overall and PCa-specific death. Patients and Methods We evaluated physical activity in relation to overall and PCa mortality among 2,705 men in the Health Professionals Follow-Up Study diagnosed with nonmetastatic PCa observed from 1990 to 2008. Proportional hazards models were used to evaluate physical activity and time to overall and PCa-specific death. Results Among men who lived at least 4 years after their postdiagnosis physical activity assessment, we documented 548 deaths, 20% of which were a result of PCa. In multivariable analysis, men who were physically active had lower risk of all-cause mortality (Ptrend < .001) and PCa mortality (Ptrend = .04). Both nonvigorous activity and vigorous activity were associated with significantly lower overall mortality. Those who walked ≥ 90 minutes per week at a normal to very brisk pace had a 46% lower risk of all-cause mortality (hazard ratio [HR] 0.54; 95% CI, 0.41 to 0.71) compared with shorter durations at an easy walking pace. Men with ≥ 3 hours per week of vigorous activity had a 49% lower risk of all-cause mortality (HR, 0.51; 95% CI, 0.36 to 0.72). For PCa-specific mortality, brisk walking at longer durations was suggestively inverse but not statistically significant. Men with ≥ 3 hours per week of vigorous activity had a 61% lower risk of PCa death (HR, 0.39, 95% CI, 0.18 to 0.84; P = .03) compared with men with less than 1 hour per week of vigorous activity. Men exercising vigorously before and after diagnosis had the lowest risk. Conclusion In men with PCa, physical activity was associated with lower overall mortality and PCa mortality. A modest amount of vigorous activity such as biking, tennis, jogging, or swimming for ≥ 3 hours a week may substantially improve PCa-specific survival.

Download Full-text