scholarly journals MP21-01 MOLECULAR TUMOR PROFILING TO IDENTIFY MECHANISMS LINKING STATINS WITH LOWER RISK OF LETHAL PROSTATE CANCER

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Emma Allott ◽  
Ericka Noonan ◽  
Amparo Gonzalez-Feliciano ◽  
Sarah Markt ◽  
Kathryn Wilson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lower Risk ◽  
Tumor Profiling ◽  
Lethal Prostate Cancer

scholarly journals Alcohol Intake and Risk of Lethal Prostate Cancer in the Health Professionals Follow-Up Study

2019 ◽  
Vol 37 (17) ◽  
pp. 1499-1511 ◽  
Author(s):  
Mary K. Downer ◽  
Stacey A. Kenfield ◽  
Meir J. Stampfer ◽  
Kathryn M. Wilson ◽  
Barbra A. Dickerman ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
At Risk ◽  
Health Professionals ◽  
Lower Risk ◽  
Alcohol Intake ◽  
Red Wine ◽  
Follow Up Study ◽  
Total Alcohol ◽  
Lethal Prostate Cancer

PURPOSE It is unknown whether alcohol intake is associated with the risk of lethal (metastatic or fatal) prostate cancer. We examine (1) whether alcohol intake among men at risk of prostate cancer is associated with diagnosis of lethal prostate cancer and (2) whether intake among men with nonmetastatic prostate cancer is associated with metastasis or death. METHODS This prospective cohort study uses the Health Professionals Follow-Up Study (1986 to 2012). Our analysis of alcohol intake among men at risk of prostate cancer included 47,568 cancer-free men. Our analysis of alcohol intake among men with prostate cancer was restricted to 5,182 men diagnosed with nonmetastatic prostate cancer during follow-up. We examine the association of total alcohol, red and white wine, beer, and liquor with lethal prostate cancer and death. Multivariate Cox proportional hazards regression estimated hazard ratios (HRs) and 95% CIs. RESULTS Alcohol drinkers had a lower risk of lethal prostate cancer (any v none: HR, 0.84 [95% CI, 0.71 to 0.99]) without a dose-response relationship. Total alcohol intake among patients with prostate cancer was not associated with progression to lethal prostate cancer (any v none: HR, 0.99 [95% CI, 0.57 to 1.72]), whereas moderate red wine intake was associated with a lower risk (any v none: HR, 0.50 [95% CI, 0.29 to 0.86]; P trend = .05). Compared with none, 15 to 30 g/d of total alcohol after prostate cancer diagnosis was associated with a lower risk of death (HR, 0.71 [95% CI, 0.50 to 1.00]), as was red wine (any v none: HR, 0.74 [95% CI, 0.57 to 0.97]; P trend = .007). CONCLUSION Cancer-free men who consumed alcohol had a slightly lower risk of lethal prostate cancer compared with abstainers. Among men with prostate cancer, red wine was associated with a lower risk of progression to lethal disease. These observed associations merit additional study but provide assurance that moderate alcohol consumption is safe for patients with prostate cancer.

scholarly journals Statin Use Is Associated with Lower Risk of PTEN-Null and Lethal Prostate Cancer

2019 ◽  
Vol 26 (5) ◽  
pp. 1086-1093 ◽  
Author(s):  
Emma H. Allott ◽  
Ericka M. Ebot ◽  
Konrad H. Stopsack ◽  
Amparo G. Gonzalez-Feliciano ◽  
Sarah C. Markt ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lower Risk ◽  
Statin Use ◽  
Lethal Prostate Cancer

ONECUT2 Is a Targetable Master Regulator of Lethal Prostate Cancer That Suppresses the Androgen Axis

2018 ◽  
Author(s):  
Mirja Rotinen ◽  
Sungyong You ◽  
Julie Yang ◽  
Simon Coetzee ◽  
Wen-Chin Huang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Master Regulator ◽  
Lethal Prostate Cancer

scholarly journals The Association of Nighttime Fasting Duration and Prostate Cancer Risk: Results from the Multicase-Control (MCC) Study in Spain

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2662
Author(s):  
Anna Palomar-Cros ◽  
Ana Espinosa ◽  
Kurt Straif ◽  
Beatriz Pérez-Gómez ◽  
Kyriaki Papantoniou ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Lower Risk ◽  
Night Shift ◽  
Prostate Cancer Risk ◽  
Meal Timing ◽  
Risk Of Cancer ◽  
Fasting Duration ◽  
Population Controls ◽  
Reduced Risk

Nighttime fasting has been inconclusively associated with a reduced risk of cancer. The purpose of this study was to investigate this association in relation to prostate cancer risk. We examined data from 607 prostate cancer cases and 848 population controls who had never worked in night shift work from the Spanish multicase-control (MCC) study, 2008–2013. Through an interview, we collected circadian information on meal timing at mid-age. We estimated odds ratios (OR) and 95% confidence intervals (CI) with unconditional logistic regression. After controlling for time of breakfast, fasting for more than 11 h overnight (the median duration among controls) was associated with a reduced risk of prostate cancer compared to those fasting for 11 h or less (OR = 0.77, 95% 0.54–1.07). Combining a long nighttime fasting and an early breakfast was associated with a lower risk of prostate cancer compared to a short nighttime fasting and a late breakfast (OR = 0.54, 95% CI 0.27–1.04). This study suggests that a prolonged nighttime fasting duration and an early breakfast may be associated with a lower risk of prostate cancer. Findings should be interpreted cautiously and add to growing evidence on the importance of chrononutrition in relation to cancer risk.

scholarly journals Modification of the Association Between Obesity and Lethal Prostate Cancer by TMPRSS2:ERG

2013 ◽  
Vol 105 (24) ◽  
pp. 1881-1890 ◽  
Author(s):  
Andreas Pettersson ◽  
Rosina T. Lis ◽  
Allison Meisner ◽  
Richard Flavin ◽  
Edward C. Stack ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lethal Prostate Cancer

scholarly journals Asthma and risk of lethal prostate cancer in the Health Professionals Follow-Up Study

2015 ◽  
Vol 137 (4) ◽  
pp. 949-958 ◽  
Author(s):  
Elizabeth A. Platz ◽  
Charles G. Drake ◽  
Kathryn M. Wilson ◽  
Siobhan Sutcliffe ◽  
Stacey A. Kenfield ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Health Professionals ◽  
Follow Up Study ◽  
Lethal Prostate Cancer

Effect of Statins on the Risk of Different Stages of Prostate Cancer: A Meta-Analysis

2021 ◽  
pp. 1-9
Author(s):  
Yun Li ◽  
Xuan Cheng ◽  
Jia-lian Zhu ◽  
Wen-wen Luo ◽  
Huai-rong Xiang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lower Risk ◽  
Advanced Prostate Cancer ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Low Grade ◽  
High Grade ◽  
The Cochrane Library ◽  
The Relationship ◽  
Comprehensive Literature Search

<b><i>Introduction:</i></b> The aim of this article was to investigate the relationship between statins and the risk of different stages or grades of prostate cancer. <b><i>Methods:</i></b> A comprehensive literature search was performed for articles published until December 18, 2020, on the PubMed, Embase, and the Cochrane Library databases. The pooled relative risk (RR) and 95% confidence interval (CI) were then analyzed using the STATA.16.0 software. <b><i>Results:</i></b> A total of 588,055 patients from 14 studies were included in the analysis. We found that the use of statins expressed a significant correlation with a lower risk of advanced prostate cancer (RR = 0.81, 95% CI: 0.73–0.91; RR = 0.86, 95% CI: 0.75–0.99, respectively). However, no evidence suggested that the use of statins was beneficial for the prevention of localized prostate cancer incidence. Similarly, the pooled results also revealed no association between the use of statins and the risk of high-grade and low-grade prostate cancer. <b><i>Conclusion:</i></b> It has been found that the use of statins is associated with a lower risk of advanced prostate cancer but was not related to the risk of localized, low-grade, or high-grade prostate cancer.

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