Abstract 998: HEx: A computational and synthetic biology platform applied to oncology drug discovery

Author(s):  
Ulrich Schlecht ◽  
Pablo Cordero ◽  
Maureen Hillenmeyer ◽  
Ju Eun Jeon ◽  
Dan Kvitek ◽  
...  
2019 ◽  
Author(s):  
Ulrich Schlecht ◽  
Pablo Cordero ◽  
Maureen Hillenmeyer ◽  
Ju Eun Jeon ◽  
Dan Kvitek ◽  
...  

mSystems ◽  
2019 ◽  
Vol 4 (3) ◽  
Author(s):  
Sylvia Kunakom ◽  
Alessandra S. Eustáquio

ABSTRACT The biosynthetic talent of microorganisms has been harnessed for drug discovery for almost a century. Microbial metabolites not only account for the majority of antibiotics available today, but have also led to anticancer, immunosuppressant, and cholesterol-lowering drugs. Yet, inherent challenges of natural products—including inadequate supply and difficulties with structure diversification—contributed to their deprioritization as a source of pharmaceuticals. In recent years, advances in genome sequencing and synthetic biology spurred a renewed interest in natural products. Bacterial genomes encode an abundance of natural products awaiting discovery. Synthetic biology can facilitate not only discovery and improvements in supply, but also structure diversification. This perspective highlights prior accomplishments in the field of synthetic biology and natural products by the scientific community at large, including research from our laboratory. We also provide our opinion as to where we need to go to continue advancing the field.


2017 ◽  
Vol 1 (3) ◽  
pp. 241-243
Author(s):  
Jeffrey Skolnick

As is typical of contemporary cutting-edge interdisciplinary fields, computational biology touches and impacts many disciplines ranging from fundamental studies in the areas of genomics, proteomics transcriptomics, lipidomics to practical applications such as personalized medicine, drug discovery, and synthetic biology. This editorial examines the multifaceted role computational biology plays. Using the tools of deep learning, it can make powerful predictions of many biological variables, which may not provide a deep understanding of what factors contribute to the phenomena. Alternatively, it can provide the how and the why of biological processes. Most importantly, it can help guide and interpret what experiments and biological systems to study.


2015 ◽  
Author(s):  
Joy M. Fulbright ◽  
Kathleen Neville ◽  
Melinda Broward ◽  
Tyce A. Bruns ◽  
Anuradha Roy ◽  
...  

2019 ◽  
Vol 24 (5) ◽  
pp. 1067-1073 ◽  
Author(s):  
Nicola Colclough ◽  
Kan Chen ◽  
Peter Johnström ◽  
Markus Fridén ◽  
Dermot F. McGinnity

2014 ◽  
Vol 4 (4) ◽  
pp. 397-404 ◽  
Author(s):  
Carlo Toniatti ◽  
Philip Jones ◽  
Hilary Graham ◽  
Bruno Pagliara ◽  
Giulio Draetta
Keyword(s):  

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