Abstract P3-09-06: Bintrafusp alfa (M7824), a bifunctional fusion protein targeting transforming growth factor-β and programmed death ligand 1, in advanced triple-negative breast cancer: Preliminary results from a phase 1 cohort

2020 ◽  
Author(s):  
Alexander Spira ◽  
Ahmad Awada ◽  
Nicolas Isambert ◽  
David Lorente Estellés ◽  
John Nemunaitis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Triple Negative ◽  
Protein Targeting ◽  
Transforming Growth Factor ◽  
Phase 1 ◽  
Transforming Growth Factor Β ◽  
Programmed Death Ligand 1 ◽  
Programmed Death ◽  
Bifunctional Fusion Protein

Transforming growth factor-β blockade modulates tumor mechanical microenvironment for enhanced antitumor efficacy of photodynamic therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Jitang Chen ◽  
Si Li ◽  
Xin Liu ◽  
Sha Liu ◽  
Chen Xiao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Growth Factor ◽  
Cancer Treatment ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Clinical Settings ◽  
Mechanical Microenvironment

Photodynamic therapy (PDT) is frequently used for cancer treatment in the clinical settings. However, its applications in stroma-rich solid tumors, e.g., triple negative breast cancer, are limited by the abnormal...

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