Phase I study results from an esophageal squamous cell carcinoma (ESCC) cohort treated with M7824 (MSB0011359C), a bifunctional fusion protein targeting transforming growth factor β (TGF-β) and PD-L1

Phase I ◽

Phase I Study ◽

Protein Targeting ◽

Study Results ◽

Abstract P3-09-13: Identification of a tumor biomarker in advanced triple-negative breast cancer that predicts response to bintrafusp alfa (M7824), a bifunctional fusion protein targeting transforming growth factor-β and programmed death ligand 1

10.1158/1538-7445.sabcs19-p3-09-13 ◽

2020 ◽

Author(s):

George Locke ◽

Yue Zhang ◽

Laureen S Ojalvo ◽

Christoph Helwig ◽

Alex Rolfe ◽

...

Keyword(s):

Breast Cancer ◽

Growth Factor ◽

Triple Negative ◽

Protein Targeting ◽

Tumor Biomarker ◽

Programmed Death Ligand 1 ◽

Programmed Death ◽

237 Transforming Growth Factor-β and Notch1 Cooperate to Repress NOTCH3 to Facilitate Epithelial-Mesenchymal Transition and Tumor Initiating Capability in Esophageal Squamous Cell Carcinoma

Gastroenterology ◽

10.1016/s0016-5085(13)60183-3 ◽

2013 ◽

Vol 144 (5) ◽

pp. S-52

Author(s):

Mitsuteru Natsuizaka ◽

Shingo Kagawa ◽

Kelly A. Whelan ◽

Sanders Chang ◽

Hideaki Kinugasa ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Growth Factor ◽

Cell Carcinoma ◽

Squamous Cell ◽

Epithelial Mesenchymal Transition ◽

Mesenchymal Transition

AB053. P-21. M7824 (MSB0011359C), a bifunctional fusion protein targeting transforming growth factor β (TGF-β) and PD-L1, in Asian patients with pretreated biliary tract cancer (BTC): efficacy by BTC subtype

HepatoBiliary Surgery and Nutrition ◽

10.21037/hbsn.2019.ab053 ◽

2019 ◽

Vol 8 (S1) ◽

pp. AB053-AB053

Author(s):

Changhoon Yoo ◽

Do-Youn Oh ◽

Hye Jin Choi ◽

Masatoshi Kudo ◽

Makoto Ueno ◽

...

Keyword(s):

Growth Factor ◽

Fusion Protein ◽

Biliary Tract ◽

Biliary Tract Cancer ◽

Protein Targeting ◽

Tract Cancer ◽

Asian Patients ◽

Overexpression and Interactions of Interleukin-10, Transforming Growth Factor β, and Vascular Endothelial Growth Factor in Esophageal Squamous Cell Carcinoma

World Journal of Surgery ◽

10.1007/s00268-009-0070-y ◽

2009 ◽

Vol 33 (7) ◽

pp. 1439-1445 ◽

Cited By ~ 37

Author(s):

Mehran Gholamin ◽

Omeed Moaven ◽

Bahram Memar ◽

Moein Farshchian ◽

Hossein Naseh ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Squamous Cell Carcinoma ◽

Growth Factor ◽

Cell Carcinoma ◽

Interleukin 10 ◽

Vascular Endothelial ◽

Endothelial Growth Factor

Abstract P3-09-06: Bintrafusp alfa (M7824), a bifunctional fusion protein targeting transforming growth factor-β and programmed death ligand 1, in advanced triple-negative breast cancer: Preliminary results from a phase 1 cohort

10.1158/1538-7445.sabcs19-p3-09-06 ◽

2020 ◽

Cited By ~ 1

Author(s):

Alexander Spira ◽

Ahmad Awada ◽

Nicolas Isambert ◽

David Lorente Estellés ◽

John Nemunaitis ◽

...

Keyword(s):

Breast Cancer ◽

Growth Factor ◽

Triple Negative ◽

Protein Targeting ◽

Phase 1 ◽

Programmed Death Ligand 1 ◽

Programmed Death ◽

M7824 (MSB0011359C), a bifunctional fusion protein targeting transforming growth factor β (TGF-β) and PD-L1, in Asian patients with pretreated biliary tract cancer (BTC): Efficacy by BTC subtype

Annals of Oncology ◽

10.1093/annonc/mdy432.005 ◽

2018 ◽

Vol 29 ◽

pp. ix48-ix49 ◽

Cited By ~ 3

Author(s):

C. Yoo ◽

D.-Y. Oh ◽

H.J. Choi ◽

M. Kudo ◽

M. Ueno ◽

...

Keyword(s):

Growth Factor ◽

Fusion Protein ◽

Biliary Tract ◽

Biliary Tract Cancer ◽

Protein Targeting ◽

Tract Cancer ◽

Asian Patients ◽

Lack of activated Smad2 in transforming growth factor-β signaling is an unfavorable prognostic factor in patients with esophageal squamous cell carcinoma

Journal of Surgical Oncology ◽

10.1002/jso.20565 ◽

2006 ◽

Vol 94 (1) ◽

pp. 51-56 ◽

Cited By ~ 16

Author(s):

Minoru Fukuchi ◽

Masanobu Nakajima ◽

Tatsuya Miyazaki ◽

Norihiro Masuda ◽

Hidenobu Osawa ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Growth Factor ◽

Prognostic Factor ◽

Cell Carcinoma ◽

Squamous Cell ◽

Unfavorable Prognostic Factor

Phase I study of liposomal irinotecan (LY01610) in patients with advanced esophageal squamous cell carcinoma

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-021-04294-2 ◽

2021 ◽

Author(s):

Yun Liu ◽

Bo Zhang ◽

Jianping Xu ◽

Xingyuan Wang ◽

Jialin Tang ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Phase I ◽

Cell Carcinoma ◽

Squamous Cell ◽

Phase I Study ◽

Liposomal Irinotecan

Is the cellular location of transforming growth factor β receptors a key to biologic behavior of verrucous versus ordinary squamous cell carcinoma?

Advances in Anatomic Pathology ◽

10.1097/00125480-200007040-00016 ◽

2000 ◽

Vol 7 (4) ◽

pp. 256

Author(s):

&NA;

Keyword(s):

Squamous Cell Carcinoma ◽

Growth Factor ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cellular Location

First-In-Human Phase I Study of a Next-Generation, Oral, Transforming Growth Factor-Beta Receptor 1 Inhibitor, LY3200882 in Patients with Advanced Cancer

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-21-1504 ◽

2021 ◽

pp. clincanres.1504.2021

Author(s):

Timothy A. Yap ◽

María Vieito ◽

Capucine Baldini ◽

Juan Manuel Sepúlveda-Sánchez ◽

Shunsuke Kondo ◽

...

Keyword(s):

Growth Factor ◽

Phase I ◽

Advanced Cancer ◽

Transforming Growth Factor Beta ◽

Phase I Study ◽

Next Generation ◽

Beta Receptor ◽

Growth Factor Beta