Abstract P4-12-32: Intensity modulated radiotherapy (IMRT) for breast and lymph node irradiation

2020 ◽  
Author(s):  
Wassim El Amine ◽  
Laurent Bartolucci ◽  
Camille Adrien ◽  
Marie Lejars ◽  
Alain Fourquet ◽  
...  
Keyword(s):  
Lymph Node ◽  
Intensity Modulated Radiotherapy ◽  
Intensity Modulated ◽  
Lymph Node Irradiation

scholarly journals Patterns of regional lymph node failure of locally advanced hypopharyngeal  squamous cell carcinoma after first-line treatment with surgery and/or intensity-modulated radiotherapy

2020 ◽  
Author(s):  
Dongqing Wang ◽  
Shui Yu ◽  
Limin Zhai ◽  
Jin Xu ◽  
Baosheng Li
Keyword(s):  
Lymph Node ◽  
Regional Lymph Node ◽  
Locally Advanced ◽  
Intensity Modulated Radiotherapy ◽  
First Line ◽  
Node Failure ◽  
Intensity Modulated ◽  
Level Ii ◽  
Nodal Failure ◽  
First Line Treatment

Abstract Background : To identify the spatial patterns of regional lymph node failure of locally advanced hypopharyngeal squamous cell carcinoma (SCC) after first-line treatment with surgery and/or intensity-modulated radiotherapy (IMRT). Methods : We retrospectively obtained the clinicopathological characters of 123 hypopharyngeal SCC patients, and investigated the patterns of regional lymph node failure. Univariate and multivariate logistic regression were used to determine the risk factors of regional lymph node failure. Results : Forty patients (32.5% of total patients) were suffered regional lymph node failure. In these patients, the ipsilateral neck level II nodal failure account for 55.0% (22/40) followed by level III 30.0% (12/40), level VIb 15.0% (6/40), level VII 15.0% (6/40), and level IV 5.0% (2/40). In addition, 17.5% (7/40) patients suffered contralateral neck level II nodal failure and 7.5% (3/40) patients suffered level III nodal failure. The common failure levels were the II (7/46, 15.2%), III (4/46, 8.7%), VIb (4/46, 8.7%), and VII (5/46, 10.9%) for treatment by surgery. The lymph node recurrence and persistent disease at levels II (19/77, 24.7%) and III (10/77, 13.0%) remained the major cause of failure following curative intent of IMRT. The postoperative radiation significantly decreased the risk of regional lymph node failure (OR=0.082, 95% CI: 0.007–1.000, P=0.049); and the radiologic extranodal extension significantly increased the risk of regional lymph node failure (OR=11.07, 95% CI: 2.870–42.69, P<0.001). Conclusions: Whatever the treatment modality, the lymph node failure at level II and III was the most popular pattern for hypopharyngeal SCC. Moreover, for patients who underwent surgery, the nodal failure at level VIb and VII was frequent. Thus, postoperative radiation of level VIb and VII may give rise to benefit to locally advanced hypopharyngeal SCC patients.

scholarly journals Patterns of regional lymph node failure of locally advanced hypopharyngeal squamous cell carcinoma after first-line treatment with surgery and/or intensity-modulated radiotherapy

2020 ◽  
Author(s):  
Dongqing Wang ◽  
Shui Yu ◽  
Limin Zhai ◽  
Jin Xu ◽  
Baosheng Li
Keyword(s):  
Lymph Node ◽  
Regional Lymph Node ◽  
Locally Advanced ◽  
Intensity Modulated Radiotherapy ◽  
First Line ◽  
Node Failure ◽  
Intensity Modulated ◽  
Level Ii ◽  
Nodal Failure ◽  
First Line Treatment

Abstract Background: To identify the spatial patterns of regional lymph node failure of locally advanced hypopharyngeal squamous cell carcinoma (SCC) after first-line treatment with surgery and/or intensity-modulated radiotherapy (IMRT).Methods: We retrospectively obtained the clinicopathological characters of 123 hypopharyngeal SCC patients, and investigated the patterns of regional lymph node failure. Univariate and multivariate logistic regression were used to determine the risk factors of regional lymph node failure.Results: Forty patients (32.5% of total patients) were suffered regional lymph node failure. In these patients, the ipsilateral neck level II nodal failure account for 55.0% (22/40) followed by level III 30.0% (12/40), level VIb 15.0% (6/40), level VII 15.0% (6/40), and level IV 5.0% (2/40). In addition, 17.5% (7/40) patients suffered contralateral neck level II nodal failure and 7.5% (3/40) patients suffered level III nodal failure. The common failure levels were the II (7/46, 15.2%), III (4/46, 8.7%), VIb (4/46, 8.7%), and VII (5/46, 10.9%) for treatment by surgery. The lymph node recurrence and persistent disease at levels II (19/77, 24.7%) and III (10/77, 13.0%) remained the major cause of failure following curative intent of IMRT. The postoperative radiation significantly decreased the risk of regional lymph node failure (OR=0.082, 95% CI: 0.007–1.000, P=0.049); and the radiologic extranodal extension significantly increased the risk of regional lymph node failure (OR=11.07, 95% CI: 2.870–42.69, P<0.001).Conclusions: Whatever the treatment modality, the lymph node failure at level II and III was the most popular pattern for hypopharyngeal SCC. Moreover, for patients who underwent surgery, the nodal failure at level VIb and VII was frequent. Thus, postoperative radiation of level VIb and VII may give rise to benefit to locally advanced hypopharyngeal SCC patients.

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