Abstract D088: Analysis of tumor mutational burden, cancer immunotherapy use and outcomes based on genomic ancestry in non-small cell lung cancer patients treated in community practice in the United States

2020 ◽  
Author(s):  
Nicole Richie ◽  
Patricia Luhn ◽  
Uzor Ogbu ◽  
Gerren Wilson ◽  
William Capra ◽  
...  
Keyword(s):  
United States ◽  
Lung Cancer ◽  
Cancer Patients ◽  
The United States ◽  
Small Cell ◽  
Community Practice ◽  
Small Cell Lung ◽  
Lung Cancer Patients ◽  
Mutational Burden ◽  
Tumor Mutational Burden

scholarly journals Temporal patterns of care and outcomes of non-small cell lung cancer patients in the United States diagnosed in 1996, 2005, and 2010

Lung Cancer ◽  
2017 ◽  
Vol 103 ◽  
pp. 66-74 ◽  
Author(s):  
Filip Kaniski ◽  
Lindsey Enewold ◽  
Anish Thomas ◽  
Shakuntala Malik ◽  
Jennifer L. Stevens ◽  
...  
Keyword(s):  
United States ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Patients ◽  
Cell Lung Cancer ◽  
The United States ◽  
Small Cell ◽  
Patterns Of Care ◽  
Small Cell Lung ◽  
Lung Cancer Patients

scholarly journals Safety outcomes in advanced non-small-cell lung cancer patients treated with first-line platinum-based regimens in the United States

2019 ◽  
Vol 11 (11) ◽  
pp. 4474-4483
Author(s):  
Lei Chen ◽  
Jong Seok Kim ◽  
Belen San Antonio ◽  
Yajun Emily Zhu ◽  
Lucy Mitchell ◽  
...  
Keyword(s):  
United States ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Patients ◽  
Cell Lung Cancer ◽  
The United States ◽  
Small Cell ◽  
Small Cell Lung ◽  
First Line ◽  
Lung Cancer Patients

Association of clinico-genomic characteristics with tumor mutational burden in small cell lung cancer patients

2020 ◽  
Author(s):  
Sumesh Kachroo ◽  
Changxia Shao ◽  
Kaushal Desai ◽  
Jinghua He ◽  
Fan Jin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Patients ◽  
Cell Lung Cancer ◽  
Treatment Patterns ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Patients ◽  
Mutational Burden ◽  
Tumor Mutational Burden

Aim: We evaluated the relationship between clinical and genomic characteristics and tumor mutational burden (TMB) in small cell lung cancer. Materials & methods: In a retrospective analysis of small cell lung cancer patients aged ≥18, we assessed treatment patterns and survival in relation to TMB; the association of clinical and genomic characteristics with TMB was determined by multivariate regression. High TMB (TMB-H) was defined as ≥10 mutations/megabase. Results: Among 186 patients, treatment patterns and overall survival were similar for TMB-H and non-TMB-H patients. TMB was determined for 179 patients, 41.9% of whom were TMB-H. Short variants of LRP1B, FAT3, MLL3, MED12 and NOTCH3 were significantly associated with TMB-H (p ≤ 0.01). Conclusion: Neither treatment patterns nor survival differed by TMB status.

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