Mutagenic transgene insertion into a region of high gene density and multiple linkage disruptions on mouse chromosome 11

2002 ◽  
Vol 97 (1-2) ◽  
pp. 100-105 ◽  
Author(s):  
N. Kleiter ◽  
I. Artner ◽  
N. Gmachl ◽  
N. Ghaffari-Tabrizi ◽  
K. Kratochwil
Genetics ◽  
2002 ◽  
Vol 161 (4) ◽  
pp. 1651-1659 ◽  
Author(s):  
Elena de la Casa-Esperón ◽  
J Concepción Loredo-Osti ◽  
Fernando Pardo-Manuel de Villena ◽  
Tammi L Briscoe ◽  
Jan Michel Malette ◽  
...  

AbstractWe observed that maternal meiotic drive favoring the inheritance of DDK alleles at the Om locus on mouse chromosome 11 was correlated with the X chromosome inactivation phenotype of (C57BL/ 6-Pgk1a × DDK)F1 mothers. The basis for this unexpected observation appears to lie in the well-documented effect of recombination on meiotic drive that results from nonrandom segregation of chromosomes. Our analysis of genome-wide levels of meiotic recombination in females that vary in their X-inactivation phenotype indicates that an allelic difference at an X-linked locus is responsible for modulating levels of recombination in oocytes.


Genetics ◽  
1984 ◽  
Vol 106 (4) ◽  
pp. 679-694
Author(s):  
Denise Gilbert ◽  
Jay Hirsh ◽  
T R F Wright

ABSTRACT Nine lethal complementation groups flanking the Drosophila Dopa decarboxylase (Ddc) gene, have been localized within 100 kb of cloned chromosomal DNA. Six of these complementation groups are within 23 kb of DNA, and all ten complementation groups, including Ddc, lie within 78-82 kb of DNA. The potential significance of this unusually high gene density is discussed.


1996 ◽  
Vol 7 (2) ◽  
pp. 163-163
Author(s):  
G. C. Voss ◽  
H. Jockusch

Genomics ◽  
1996 ◽  
Vol 34 (3) ◽  
pp. 430-432 ◽  
Author(s):  
Robert A. White ◽  
Rowland T. Hughes ◽  
Linda R. Adkison ◽  
Gail Bruns ◽  
Leonard I. Zon

1977 ◽  
Vol 19 (1) ◽  
pp. 7-13 ◽  
Author(s):  
P. McBreen ◽  
K.G. Orkwiszewski ◽  
C.J. Chern ◽  
W.J. Mellman ◽  
C.M. Croce

Genomics ◽  
1999 ◽  
Vol 62 (1) ◽  
pp. 123-128 ◽  
Author(s):  
Jan Klysik ◽  
Wei-Wen Cai ◽  
Chun Yang ◽  
Allan Bradley

Sign in / Sign up

Export Citation Format

Share Document