Measuring the Tibetan nation: Anthropometry in 1950s Kalimpong

This article explores the anthropometric survey of 5,000 Tibetans by the ethnographer HRH Prince Peter of Greece and Denmark in the northeast Indian Himalayan town of Kalimpong in the 1950s, as part of the Third Danish Expedition to Central Asia. In the context of the crisis created by the Chinese incursion into Tibet in 1950, which pushed thousands of Tibetans into India, stationary field anthropometry, rather than a mobile expedition, became Prince Peter's principal entry into Tibetan worlds. This article explores the scientific paradigms underpinning his anthropometric survey at a time when anthropology had seemingly moved on theoretically and ethically, the historical conditions and contingencies of Prince Peter's research, and the survey's representations of Tibetan peoples and places. We argue that, while Prince Peter's understanding was in essence primordialist, linking particular peoples to particular places, in practice he took a more modernist approach to ‘Tibetaness’ as contingent upon historical processes. The article concludes by reflecting on the potential significance of this vast and unique collection of historic anthropometric data for Tibetans today.

MAP4K4 mediates the SOX6-induced autophagy and reduces the chemosensitivity of cervical cancer

There are nearly 40% of cervical cancer patients showing poor response to neoadjuvant chemotherapy that can be induced by autophagy, however, the underlying mechanism has not yet been fully clarified. We previously found that Sex-determining region of Y-related high-mobility-group box 6 (SOX6), a tumor suppressor gene or oncogene in several cancers, could induce autophagy in cervical cancer. Accordingly, this study aims to investigate the mechanism of SOX6-induced autophagy and its potential significance in the platinum-based chemotherapy of cervical cancer. Firstly, we found that SOX6 could promote autophagy in cervical cancer cells depending on its HMG domain. Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) gene was identified as the direct target gene of SOX6, which was transcriptionally upregulated by binding the HMG domain of SOX6 protein to its double-binding sites within MAP4K4 gene promoter. MAP4K4 mediated the SOX6-induced autophagy through inhibiting PI3K-Akt-mTOR pathway and activating MAPK/ERK pathway. Further, the sensitivity of cervical cancer cells to cisplatin chemotherapy could be reduced by the SOX6-induced autophagy in vitro and in vivo, while such a phenomenon could be turned over by autophagy-specific inhibitor and MAP4K4 inhibitor, respectively. Moreover, cisplatin itself could promote the expression of endogenous SOX6 and subsequently the MAP4K4-mediated autophagy in cervical cancer cells, which might in turn reduce the sensitivity of these cells to cisplatin treatment. These findings uncovered the underlying mechanism and potential significance of SOX6-induced autophagy, and shed new light on the usage of MAP4K4 inhibitor or autophagy-specific inhibitor for sensitizing cervical cancer cells to the platinum-based chemotherapy.

Research Trends on the Application of Electrolyzed Water in Food Preservation and Sanitation

Electrolyzed water (EW) has been proposed as a novel promising sanitizer and cleaner in recent years. It is an effective antimicrobial and antibiofilm agent that has several advantages of being on the spot, environmentally friendly, cheap, and safe for human beings. Therefore, EW has been applied widely in various fields, including agriculture, food sanitation, livestock management, medical disinfection, clinical, and other fields using antibacterial technology. Currently, EW has potential significance for high-risk settings in hospitals and other clinical facilities. The research focus has been shifted toward the application of slightly acidic EW as more effective with some supplemental chemical and physical treatment methods such as ultraviolet radiations and ultrasound. This review article summarizes the possible mechanism of action and highlights the latest research studies in antimicrobial applications.

Role and Perspectives of Inflammation and C-Reactive Protein (CRP) in Psychosis: An Economic and Widespread Tool for Assessing the Disease

Schizophrenia is a major psychotic disorder affecting nearly 23.6 million people globally and greatly impacting the cognitive and social functioning of individuals. Multiple risk factors, including genetic, environmental, and epigenetic factors have been identified. However, the exact mechanism by which some factors aid in the development of schizophrenia is still uncertain. Acute and/or long-standing inflammation has been implicated as both a cause and effect of schizophrenia. Heightened immune responses have been documented in large cohorts of individuals with schizophrenia. While not completely known, multiple hypotheses, such as disruption of the blood–brain barrier, alterations in the kynurenine/tryptophan pathway, and increased microglial activation, have been presented to correlate inflammation with schizophrenic symptoms. Measurement of C-reactive protein (CRP) is a commonly performed and inexpensive test on patients’ serum to determine levels of systemic inflammation in the body. Multiple studies have reported an elevated CRP level in different stages of schizophrenia, indicating its potential to be used as a viable biomarker in the diagnosis and monitoring of schizophrenia along with assessing treatment response to conventional and non-conventional treatment regimens. This review aims to evaluate the role of inflammation, in general, and CRP, in particular, in the pathogenesis of schizophrenia and its potential significance in diagnostic, therapeutic, and preventative approaches towards schizophrenia and psychosis.

Cosmic ray produced Radioisotopes for studying the General Circulation in the atmosphere

The possibility of using cosmic ray produced radioisotopes for studying large scale circulation in the atmosphere has been explored recently. The potential significance of these isotopes in the field of metrology arises because of the following features in their production and properties-(l) Several radioisotopes are available whose half-lives are comparable to time scales involved in the atmospheric circulation. Four of the isotopes (S35, Be7, P33, and P32) have half-life periods ranging from three months to a fortnight, and one (Na22) has a half-life of about two and a half years, and (2) Isotope production is continuous, constant, strongly dependent on the latitude and altitude in the atmosphere and independent of meteorological factors, These isotopes can be used for investigating the nature of circulation of air in the troposphere and the detailed mechanism of exchange of air between the stratosphere and the troposphere. Experimental work on the use of these isotopes in meteorology has so far been confined mainly to determination of the concentration in rainwater by the Geophysics Research Group of the Tata Institute of Fundamental Research, Bombay. Some of the important results of these investigations are summarized in this pa per.

Botanical Potency of Chromolaena odorata Linn (Hagonoy) as Mosquitocidal

Chromolaena odorata Linn is considered an environmental weed that is traditionally used as a treatment of numerous environmental conditions such as wound healing functions and amelioration of inflammation. In this study, Chromolaena odorata linn was discovered as an alternative and natural product of mosquitocide. Based on the results gathered and obtained the stem, leaves, and roots are proven to be effective to use rather than using only one part of the plant. Furthermore, the data gathered shows that it only took a small amount of time to kill the mosquito using all parts of the Chromolaena odorata linn extract. The mosquitocidal activity of Chromolaena odorata linn had shown its potential significance, eco-friendly, and cost-effective with the presence of botanical phytochemicals (alkaloids, cardiac glycosides, anthocyanin, tannin, and flavonoids) as a source of controlling the mosquito population Keywords: botanical potency, mosquitocidal, chromolaena odorata Linn, mosquitos.

Nontypeable Haemophilus influenzae infection impedes Pseudomonas aeruginosa colonization and persistence in mouse respiratory tract

Patients with cystic fibrosis (CF) experience lifelong respiratory infections which are a significant cause of morbidity and mortality. These infections are polymicrobial in nature, and the predominant bacterial species undergo a predictable series of changes as patients age. Young patients have populations dominated by opportunists that are typically found within the microbiome of the human nasopharynx, such as nontypeable Haemophilus influenzae (NTHi); these are eventually supplanted and the population within the CF lung is later dominated by pathogens such as Pseudomonas aeruginosa ( Pa ). In this study, we investigated how initial colonization with NTHi impacts colonization and persistence of Pa in the respiratory tract. Analysis of polymicrobial biofilms in vitro by confocal microscopy revealed that NTHi promoted greater levels of Pa biofilm volume and diffusion. However, sequential respiratory infection of mice with NTHi followed by Pa resulted in significantly lower Pa as compared to infection with Pa alone. Coinfected mice also had reduced airway tissue damage and lower levels of inflammatory cytokines as compared with Pa infected mice. Similar results were observed after instillation of heat-inactivated NTHi bacteria or purified NTHi lipooligosaccharide (LOS) endotoxin prior to Pa introduction. Based on these results, we conclude that NTHi significantly reduces susceptibility to subsequent Pa infection, most likely due to priming of host innate immunity rather than a direct competitive interaction between species. These findings have potential significance with regard to therapeutic management of early life infections in patients with CF.

Importance of organisational learning management systems: A design case in a corrective service-based social organisation

The study focuses on usability provisions of learning management systems (LMS) in a corrective service organization. Under the influence of goal-directed interaction design principles in design science, the study outlines a new innovative artifact as a conceptual LMS solution that addresses the employee-centric learning model. The collective artifact represents relevant design knowledge assistive to meeting stakeholders’ contextual learning needs, for instance, demonstrating the potential significance of the developed mobile-based approach to support correctional officers in improving their learning on safety professional development. The paper concludes with a practical model that could be applied to assist correctional officers in their in-house training purposes.

Phage-encoded ribosomal protein S21 expression is linked to late stage phage replication

The ribosomal protein S21 (bS21) gene has been detected in diverse viruses with a large range of genome sizes, yet its in situ expression and potential significance have not been investigated. Here, we report five closely related clades of bacteriophages (phages) represented by 47 genomes (8 curated to completion and up to 331 kbp in length) that encode a bS21 gene. The bS21 gene is on the reverse strand within a conserved region that encodes the large terminase, major capsid protein, prohead protease, portal vertex proteins and some hypothetical proteins. These phages are predicted to infect Bacteroidetes species that inhabit a range of depths in freshwater lakes. Transcriptionally active bS21-encoding phages were sampled in the late-stage of replication, when core structural genes, bS21 and a neighboring gene of unknown function were highly expressed. Thus, our analyses suggest that bS21, which is involved in translation initiation, substitutes into the Bacteroidetes ribosomes and selects for phage transcripts during the late-stage replication when large-scale phage protein production is required for assembly of phage particles.