Association of Interleukin 1β and Receptor Antagonist Gene Polymorphisms with Primary Open-Angle Glaucoma

2003 ◽  
Vol 217 (5) ◽  
pp. 358-364 ◽  
Author(s):  
Hui-Ju Lin ◽  
San-Chang Tsai ◽  
Fuu-Jen Tsai ◽  
Wen-Chi Chen ◽  
Jeffery J.P. Tsai ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Gene Polymorphisms ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Interleukin 1Β ◽  
Open Angle

The ‐1562C/T MMP‐9 and the ‐511C/T IL‐1β gene polymorphisms in primary open‐angle glaucoma patients

2011 ◽  
Vol 89 (s248) ◽  
pp. 0-0
Author(s):  
I MAJSTEREK ◽  
L MARKIEWICZ ◽  
K PRZYBYLOWSKA ◽  
M GACEK ◽  
M WASZCZYK ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle

Association study of multiple gene polymorphisms with the risk of adult-onset primary open-angle glaucoma in a Mexican population

2013 ◽  
Vol 107 ◽  
pp. 59-64 ◽  
Author(s):  
Beatriz Buentello-Volante ◽  
Celia Elizondo-Olascoaga ◽  
Antonio Miranda-Duarte ◽  
Dalia Guadarrama-Vallejo ◽  
Jesús Cabral-Macias ◽  
...  
Keyword(s):  
Association Study ◽  
Gene Polymorphisms ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Mexican Population ◽  
Adult Onset ◽  
Open Angle ◽  
Multiple Gene

Cytokine expression in tears of patients with glaucoma or dry eye disease: A prospective, observational cohort study

2018 ◽  
Vol 29 (4) ◽  
pp. 437-443 ◽  
Author(s):  
Javier Benitez-del-Castillo ◽  
Jorge Cantu-Dibildox ◽  
Silvia M Sanz-González ◽  
Vicente Zanón-Moreno ◽  
Maria Dolores Pinazo-Duran
Keyword(s):  
Dry Eye ◽  
Interleukin 6 ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Dry Eye Disease ◽  
Interleukin 1Β ◽  
Eye Disease ◽  
Eye Drops ◽  
Healthy Controls ◽  
Open Angle

Background: The aim of this study was to assess the expression of cytokines/chemokines in tears from patients with non-advanced primary open-angle glaucoma and patients with non-severe dry eye disease versus healthy controls. Methods: This prospective, observational cohort study enrolled patients with confirmed or suspected non-advanced primary open-angle glaucoma who received any prostaglandin analogue monotherapy for longer than 6 months, patients with non-severe dry eye disease, and healthy controls. Expression of interleukin-1β, interleukin-2, interleukin-4, interleukin-5, interleukin-6, interleukin-8, interleukin-10, and interleukin-12; tumor necrosis factor α; vascular endothelial growth factor; granulocyte-macrophage colony-stimulating factor; and interferon γ was assessed. Results: 107 participants were enrolled (primary open-angle glaucoma, n = 41; dry eye disease, n = 30; and healthy controls, n = 36). Compared with healthy controls, interleukin-6 was significantly higher ( p = 0.0001) in patients with primary open-angle glaucoma and interleukin-1β ( p = 0.0144), interleukin-6 ( p < 0.0001), and interleukin-10 ( p = 0.0392) were higher in patients with dry eye disease. Compared with patients with dry eye disease, patients with primary open-angle glaucoma had significantly lower levels of interleukin-4 (21.79 vs 20.18 pg/mL; p = 0.0012) and significantly higher levels of vascular endothelial growth factor (367.75 vs 609.28 pg/mL; p = 0.0058), tumor necrosis factor α (14.27 vs 17.93 pg/mL; p = 0.0048), and interleukin-6 (17.95 vs 27.48 pg/mL; p = 0.0145). In patients with primary open-angle glaucoma, interleukin-1β expression ( p = 0.0011) was lower than in those who received intraocular pressure–lowering eye drops without preservatives compared with those who received eye drops with preservatives. Conclusion: Different cytokine/chemokine expression profiles in tears of patients with primary open-angle glaucoma and dry eye disease strongly suggest the involvement of a variety of signaling pathways in the pathogenesis of these ophthalmic processes.

“Association of APOE gene polymorphisms with primary open angle glaucoma in Brazilian patients”

2020 ◽  
pp. 1-9
Author(s):  
Marcelo Luís Occhiutto ◽  
Mônica Barbosa de Melo ◽  
José Paulo Cabral de Vasconcellos ◽  
Thiago Adalton Rosa Rodrigues ◽  
Flávia Fialho Bajano ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Apoe Gene ◽  
Open Angle

scholarly journals The role of Cat -262C/T, GPX1 Pro198Leu and Sod1+35A/C gene polymorphisms in a development of primary open-angle glaucoma in a Polish population

2016 ◽  
Vol 4 ◽  
pp. 404-410 ◽  
Author(s):  
Katarzyna Malinowska ◽  
Michał Kowalski ◽  
Jerzy Szaflik ◽  
Jerzy P. Szaflik ◽  
Ireneusz Majsterek
Keyword(s):  
Gene Polymorphisms ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Polish Population ◽  
Open Angle

scholarly journals Gene polymorphisms associated with the remodeling of the connective tissue as markers of preclinical diagnosis of primary open-angle glaucoma in patients with hereditary predisposition

2021 ◽  
pp. 26-33
Author(s):  
М.О. Кириллова ◽  
А.Н. Журавлева ◽  
А.В. Марахонов ◽  
Н.В. Петрова ◽  
Н.В. Балинова ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Gene Polymorphisms ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Molecular Genetic ◽  
Ophthalmological Examination ◽  
Open Angle ◽  
Hereditary Predisposition ◽  
Group I ◽  
Preclinical Diagnosis

Цель исследования - изучение взаимосвязи полиморфизмов генов, кодирующих структуру регуляторных белков синтеза и деградации экстрацеллюлярного матрикса соединительной ткани, с развитием первичной открытоугольной глаукомы (ПОУГ). Обследовано 144 человека (мужчин - 56, женщин - 88), средний возраст 59,3±6,2, не состоящих в родстве, русской национальности. Группу I составили 40 человек с подозрением на глаукому, в группу II вошли 40 человек с диагнозом ПОУГ I-II стадий на одном или обоих глазах. Пациенты обеих групп имели отягощенный семейный анамнез по глаукоме. Группу контроля составили 64 относительно здоровых человека. Всем пациентам проведены стандартные и специальные офтальмологические, а также молекулярно-генетические исследования. Носительство генотипа GT и аллеля Т полиморфизма rs8136803 (TIMP3), генотипа AG и аллеля A полиморфизма rs652438 (MMP12), генотипа GA и аллеля A полиморфизма rs3825942 (LOXL1) ассоциировано с развитием ПОУГ. Ассоциации полиморфизма rs1048661 гена LOXL1 с развитием ПОУГ не выявлено. Проведенное исследование указывает на необходимость формирования алгоритма обследования пациентов с ПОУГ и подозрением на глаукому с включением молекулярно-генетических исследований. Objective: to study gene polymorphisms associated with the remodeling of the connective tissue of the eye as markers of preclinical diagnosis of primary open-angle glaucoma in patients with hereditary predisposition. Materials and methods: a total of 144 persons (56 men, 88 women), average age 59.3±6.2, were examined, not related, of Russian nationality. Group I consisted of 40 individuals suspected to affected by glaucoma, group II included 40 individuals with a diagnosis of I-II stage POAG in one or both eyes. Patients of both groups had a complicated family history of glaucoma. The control group consisted of 64 relatively healthy individuals. All patients underwent standard and special ophthalmological examination, as well as molecular genetic testing. Results: carriage of GT genotype and T allele of rs8136803 polymorphism (TIMP3), AG genotype and A allele of rs652438 polymorphism (MMP12), GA genotype and A allele of rs3825942 polymorphism (LOXL1) was associated with the development of POAG. The rs1048661 polymorphism of the LOXL1 gene cannot be considered as a marker of POAG development. Conclusion: the study indicates the need to develop a correct algorithm for diagnosing patients with POAG and suspected glaucoma with the inclusion of molecular genetic studies.

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