Angiotensin-Converting Enzyme in Cortical Tissue in Alzheimer's and Some Other Neurological Diseases

1992 ◽  
Vol 3 (5-6) ◽  
pp. 299-303 ◽  
Author(s):  
E.G. McGeer ◽  
E.A. Singh
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Neurological Diseases ◽  
Converting Enzyme ◽  
Cortical Tissue

Angiotensin-converting enzyme (ACE) and ACE2 levels in the cerebrospinal fluid of patients with multiple sclerosis

2008 ◽  
Vol 15 (2) ◽  
pp. 262-265 ◽  
Author(s):  
M Kawajiri ◽  
M Mogi ◽  
N Higaki ◽  
T Matsuoka ◽  
Y Ohyagi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Angiotensin Ii ◽  
Angiotensin Converting Enzyme ◽  
Neurological Diseases ◽  
Renin Angiotensin System ◽  
Converting Enzyme ◽  
Angiotensin System ◽  
Renin Angiotensin

Background We reported a reduction in the levels of angiotensin II in cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS). Objective and methods To clarify the mechanism underlying this reduction, we assayed angiotensin-converting enzyme (ACE) and ACE2 concentrations along with angiotensin II concentrations in CSF samples from 20 patients with MS and 17 controls with non-neurological diseases. Results ACE levels were significantly elevated in patients with MS compared with controls (48.42 ± 4.84 vs 44.71 ± 3.9 pg/mL), whereas ACE2 levels were significantly reduced (2.56 ± 0.26 vs 2.78 ± 0.24 pg/mL), acting toward a normalization of angiotensin II levels. Conclusion These results further indicate an alteration of the intrathecal renin-angiotensin system in patients with MS.

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