Effects of Acute Hypotensive Hemorrhage on Arginine Vasopressin Gene Transcription in the Rat Brain

1993 ◽  
Vol 58 (6) ◽  
pp. 630-636 ◽  
Author(s):  
Masaru Shoji ◽  
Tokihisa Kimura ◽  
Yutaka Kawarabayasi ◽  
Kozo Ota ◽  
Minoru Inoue ◽  
...  
Keyword(s):  
Rat Brain ◽  
Gene Transcription ◽  
Arginine Vasopressin ◽  
Vasopressin Gene

Diurnal changes in arginine vasopressin gene transcription in the rat suprachiasmatic nucleus

2002 ◽  
Vol 104 (2) ◽  
pp. 132-136 ◽  
Author(s):  
Yuko Yambe ◽  
Hiroshi Arima ◽  
Satoshi Kakiya ◽  
Takashi Murase ◽  
Yutaka Oiso
Keyword(s):  
Suprachiasmatic Nucleus ◽  
Gene Transcription ◽  
Arginine Vasopressin ◽  
Diurnal Changes ◽  
Vasopressin Gene

scholarly journals Transcription factor CREB3L1 mediates cAMP and glucocorticoid regulation of arginine vasopressin gene transcription in the rat hypothalamus

2015 ◽  
Vol 8 (1) ◽  
Author(s):  
Mingkwan Greenwood ◽  
Michael P. Greenwood ◽  
Andre S. Mecawi ◽  
Su Yi Loh ◽  
José Antunes Rodrigues ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Gene Transcription ◽  
Arginine Vasopressin ◽  
Rat Hypothalamus ◽  
Vasopressin Gene

Effects of acute hypotensive stimuli on arginine vasopressin gene transcription in the rat hypothalamus

2000 ◽  
Vol 279 (4) ◽  
pp. E886-E892 ◽  
Author(s):  
Satoshi Kakiya ◽  
Hiroshi Arima ◽  
Hisashi Yokoi ◽  
Takashi Murase ◽  
Yuko Yambe ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Gene Transcription ◽  
Arginine Vasopressin ◽  
The Other ◽  
Paraventricular Nuclei ◽  
Vasopressin Gene ◽  
Avp Gene

We investigated the baroregulation of arginine vasopressin (AVP) gene transcription in the supraoptic (SON) and paraventricular nuclei (PVN) in conscious rats by use of intronic in situ hybridization. Hemorrhage of 16 ml/kg body wt decreased mean arterial pressure (MAP) by 57% and increased both plasma AVP (control, 1.2 ± 0.3 pg/ml; 16 ml/kg body wt, 38.9 ± 3.2 pg/ml) at 10 min and AVP heteronuclear (hn)RNA levels (SON, 150%; PVN, 140% of control values) at 20 min. On the other hand, hemorrhage of 7 ml/kg body wt had no significant effect on MAP, plasma AVP, or the AVP hnRNA levels. To better understand the baroregulation, we also examined the effects of sodium nitroprusside (SNP), which induces hypotension without a change in blood volume. The subcutaneous injection of 2 mg/kg body wt SNP, which decreased the MAP by 60%, increased both plasma AVP (control, 1.6 ± 0.4 pg/ml; 2 mg/kg body wt, 8.1 ± 0.4 pg/ml) at 10 min and AVP hnRNA levels (SON, 150%; PVN, 140% of control values) at 30 min. The injection of 0.1 mg/kg body wt SNP, which reduced the MAP by 10%, failed to increase either the plasma AVP or AVP hnRNA levels. These results indicate that AVP gene transcription increases rapidly after both hypotensive hemorrhage and normovolemic hypotension. In addition, it is suggested that the set point for AVP synthesis in the baroregulation is similar to that for AVP release.

Acute Hypotensive Hemorrhage Stimulates Vasopressin Gene Transcription in the Rat Brain

1993 ◽  
Vol 689 (1 The Neurohypo) ◽  
pp. 670-673
Author(s):  
MASARU SHOJI ◽  
TOKIHISA KIMURA ◽  
KOZO OTA ◽  
MINORU INOUE ◽  
KAZUTOSHI SATO ◽  
...  
Keyword(s):  
Rat Brain ◽  
Gene Transcription ◽  
Vasopressin Gene

scholarly journals In SituHybridization Analysis of Arginine Vasopressin Gene Transcription Using Intron-Specific Probes

1991 ◽  
Vol 5 (10) ◽  
pp. 1447-1456 ◽  
Author(s):  
James P. Herman ◽  
Martin K.-H. Schäfer ◽  
Stanley J. Watson ◽  
Thomas G. Sherman
Keyword(s):  
Gene Transcription ◽  
Arginine Vasopressin ◽  
In Situhybridization ◽  
Vasopressin Gene

scholarly journals Autosomal dominant familial neurohypophyseal diabetes insipidus caused by a novel mutation in arginine-vasopressin gene in a Brazilian family

2008 ◽  
Vol 52 (8) ◽  
pp. 1272-1276 ◽  
Author(s):  
Maria Edna de Melo ◽  
Suemi Marui ◽  
Vinícius Nahime de Brito ◽  
Marcio Corrêa Mancini ◽  
Berenice B. Mendonca ◽  
...  
Keyword(s):  
Diabetes Insipidus ◽  
Arginine Vasopressin ◽  
Autosomal Dominant ◽  
Novel Mutation ◽  
Direct Sequencing ◽  
Sequencing Analysis ◽  
The Novel ◽  
Autosomal Dominant Disorder ◽  
Vasopressin Gene ◽  
Avp Gene

Autosomal dominant familial neurohypophyseal diabetes insipidus (adFNDI) is a rare autosomal dominant disorder characterized by polyuria and polydipsia due to deficiency of arginine vasopressin (AVP). More than 50 mutations causing adFNDI have been already reported in the AVP gene. The aim of the present study is to analyze the AVP gene in four generations of one Brazilian kindred with adFNDI. The proband was a 31-year old female with huge hypotonic polyuria (10 L/day) dated from childhood. Molecular analysis included amplification of all exons and exon-intron regions of the AVP gene by PCR and direct sequencing. Sequencing analysis showed a novel point mutation in heterozygous: G88V (GGC>GTC). All affected patients presented the same mutation also in heterozygous, while it was absent in four normal members. We expand the repertoire of mutations in AVP describing the novel G88V mutation in one Brazilian kindred with adFNDI.

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