scholarly journals Urinary Tract Infection Requiring Nephrectomy in a Patient with Autosomal Dominant Polycystic Kidney Disease despite Ciprofloxacin Therapy

Nephron ◽  
1993 ◽  
Vol 65 (4) ◽  
pp. 638-639 ◽  
Author(s):  
Cem Sungur ◽  
Arzu Sungur ◽  
Ali Ergen ◽  
Unal Yasavul ◽  
Cetin Turgan ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Kidney Disease ◽  
Tract Infection ◽  
Polycystic Kidney Disease ◽  
Autosomal Dominant ◽  
Polycystic Kidney ◽  
Autosomal Dominant Polycystic Kidney

scholarly journals Insights into cellular and molecular basis for urinary tract infection in autosomal-dominant polycystic kidney disease

2017 ◽  
Vol 313 (5) ◽  
pp. F1077-F1083 ◽  
Author(s):  
Chao Gao ◽  
Long Zhang ◽  
Ye Zhang ◽  
Darren P. Wallace ◽  
Reynold I. Lopez-Soler ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Kidney Disease ◽  
Tract Infection ◽  
Polycystic Kidney Disease ◽  
Molecular Mechanisms ◽  
Autosomal Dominant ◽  
Immune Defense ◽  
Polycystic Kidney ◽  
Autosomal Dominant Polycystic Kidney

Urinary tract infection (UTI) is a broad term referring to an infection of the kidneys, ureters, bladder, and/or urethra. Because of its prevalence, frequent recurrence, and rising resistance to antibiotics, UTI has become a challenge in clinical practice. Autosomal-dominant polycystic kidney disease (ADPKD) is the most common monogenic disorder of the kidney and is characterized by the growth of fluid-filled cysts in both kidneys. Progressive cystic enlargement, inflammation, and interstitial fibrosis result in nephron loss with subsequent decline in kidney function. ADPKD patients frequently develop UTI; however, the cellular and molecular mechanisms responsible for the high UTI incidence in ADPKD patients remain virtually unaddressed. Emerging evidence suggests that α-intercalated cells (α-ICs) of the collecting ducts function in the innate immune defense against UTI. α-ICs inhibit bacterial growth by acidifying urine and secreting neutrophil gelatinase-associated lipocalin (NGAL) that chelates siderophore-containing iron. It is necessary to determine, therefore, if ADPKD patients with recurrent UTI have a reduced number and/or impaired function of α-ICs. Identification of the underlying cellular and molecular mechanisms may lead to the development of novel strategies to reduce UTI in ADPKD.

scholarly journals Dialysis and a urinary tract infection in patients with autosomal dominant polycystic kidney disease

Health of Man ◽  
2017 ◽  
Vol 0 (2(61)) ◽  
pp. 62-65
Author(s):  
В. М. Лісовий ◽  
Н. М. Андон’єва ◽  
О. А. Гуц ◽  
М. Я. Дубовик ◽  
М. М. Поляков ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Kidney Disease ◽  
Tract Infection ◽  
Polycystic Kidney Disease ◽  
Autosomal Dominant ◽  
Polycystic Kidney ◽  
Autosomal Dominant Polycystic Kidney

scholarly journals Complications in Patients With Autosomal Dominant Polycystic Kidney Disease Undergoing Ureteroscopy: A Cohort Study

2020 ◽  
Vol 7 ◽  
pp. 205435812097283
Author(s):  
Vinusha Kalatharan ◽  
Blayne Welk ◽  
Danielle M. Nash ◽  
Eric McArthur ◽  
Justin Slater ◽  
...  
Keyword(s):  
Emergency Department ◽  
Cohort Study ◽  
Urinary Tract ◽  
Kidney Disease ◽  
Hospital Admission ◽  
Polycystic Kidney Disease ◽  
Emergency Department Visit ◽  
Autosomal Dominant ◽  
Polycystic Kidney ◽  
Autosomal Dominant Polycystic Kidney

Background: Ureteroscopy is a minimally invasive treatment option for upper tract stones. The distorted kidney anatomy in patients with autosomal dominant polycystic kidney disease (ADPKD) may place them at higher risk for ureteroscopic complications. Objective: To compare the 30-day risk of ureteroscopic complications between patients with and without ADPKD. Design: Retrospective cohort study. Setting: Ontario, Canada Patients: Seventy three patients with ADPKD and 81 445 patients without ADPKD who underwent ureteroscopy for upper urinary tract stones between April 1, 2002, and March 1, 2018. Measurements: A 30-day risk of (1) hospital presentation with ureteroscopic complications (which was a composite outcome of either emergency department visit or hospital admission with acute kidney injury, urinary tract infection, or sepsis); (2) all-cause hospital presentation; (3) all-cause hospital admission; and (4) all-cause emergency department visit. Methods: We regressed outcomes on demographic variables, health care use in the prior 1-year, various procedures and comorbidities related to the outcome in the prior 5 years, and prescribed medications filled in the past 120 days using modified Poisson regression to compare the risk ratio (RR) of each outcome between patients with and without ADPKD. Results: The median (interquartile, IQR) age was 44 (38-60 years) in the ADPKD group and 53 (42-64) in the control group. About 40% were women in both groups. The risk of ureteroscopic complications was not significantly different in patients with versus without ADPKD (8.2% vs 4.3%; adjusted RR = 1.5, 95% confidence interval [CI] = 0.7-3.2). Patients with versus without ADPKD were more likely to present to hospital after their procedure (35.6% vs. 20.0%; adjusted RR = 1.6, 95% CI = 1.2-2.2), which included a statistically significant increase in the risk of presenting to the emergency department (32.9% vs. 19.0%; adjusted RR = 1.6, 95% CI = 1.1-2.2) but not hospital admissions (10.9% vs. 5.0%; adjusted RR = 1.8, 95% CI = 0.9-3.4). Limitations: The low numbers of events led to imprecision around the estimates. Conclusion: Patients with ADPKD have a higher risk of return to the hospital within 30 days of ureteroscopy for stone disease. Trial registration: We did not register this study.

scholarly journals END STAGE POLYCYSTIC KIDNEY DISEASE: THE STUDY FOR UPPER URINARY TRACT INFECTION ^|^amp; HEMORRHAGE INTO THE CYSTS

1994 ◽  
Vol 85 (11) ◽  
pp. 1673-1678
Author(s):  
Shinichi Ohshima ◽  
Tamio Fujita ◽  
Yoshinari Ono ◽  
Norio Katoh ◽  
Osamu Matsuura ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Kidney Disease ◽  
Tract Infection ◽  
Polycystic Kidney Disease ◽  
Upper Urinary Tract ◽  
Polycystic Kidney ◽  
End Stage

scholarly journals Prostatic cyst in autosomal dominant polycystic kidney disease: unusual association

2019 ◽  
Vol 12 (4) ◽  
pp. e228617
Author(s):  
Vivek Sood ◽  
Navin Pattanashetti ◽  
Mohamed Bilal Azam ◽  
Raja Ramachandran
Keyword(s):  
Urinary Tract Infection ◽  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Recurrent Urinary Tract Infection ◽  
Autosomal Dominant ◽  
Polycystic Kidney ◽  
Outflow Obstruction ◽  
Unusual Association ◽  
Autosomal Dominant Polycystic Kidney ◽  
Prostatic Cyst

Prostate cyst, as an extrarenal manifestation in patients with autosomal dominant polycystic kidney disease, although infrequent, nevertheless goes beyond tenuous concomitance and may rarely contribute to recurrent urinary tract infection or outflow obstruction and mostly remains asymptomatic. In this context, we report a case of incidentally detected, an asymptomatic prostatic cyst in a patient of autosomal dominant polycystic kidney disease.

scholarly journals Native nephrectomy in transplant patients with autosomal dominant polycystic kidney disease

2011 ◽  
Vol 93 (5) ◽  
pp. 391-395 ◽  
Author(s):  
P Patel ◽  
C Horsfield ◽  
F Compton ◽  
J Taylor ◽  
G Koffman ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Autosomal Dominant ◽  
Successful Outcome ◽  
Morbidity Rate ◽  
Polycystic Kidney ◽  
Surgical Morbidity ◽  
Transplant Patients ◽  
Autosomal Dominant Polycystic Kidney

INTRODUCTION This study examined the clinical indications and timing for native nephrectomy (NN), together with the associated pathological findings in transplant patients with autosomal dominant polycystic kidney disease (ADPKD) at our institute over a period of 20 years. METHODS A retrospective review was performed of ADPKD patients who had undergone both kidney transplantation and NN. Patients were identified from the kidney transplant database between 1988 and 2008 at Guy's and St Thomas' Hospital and the notes reviewed. All NN specimens were re-reviewed and reported according to current guidelines. RESULTS There were 157 kidney transplants performed for ADPKD (114 cadaveric and 43 living donor). Of these, 31 required NN (28 bilateral). The timing of NN was pre-transplant in 10 cases, at the time of the transplant in 1 case and post-transplant in 20 cases. The indications for NN were urinary tract infection (n=14, 45%), pain (n=12, 39%), tumour suspicion (n=3, 10%), haematuria (n=1, 3%) and space (n=1, 3%). Mortality in this NN series was 3%, with a 65% surgical morbidity rate. The length of hospital stay post-NN was significantly longer with open compared with laparoscopic techniques (p=0.003). There were two renal cell carcinomas (RCCs) in this series. Both patients presented with macroscopic haematuria (bilateral pT1a papillary RCCs in one case and a pT3b clear cell RCC in the other case). The incidence of RCC in this series of ADPKD transplant patients was 1.3%. CONCLUSIONS We have demonstrated that the majority of ADPKD patients do not require NN, with only 20% of our series undergoing this procedure. The timing of NN is variable and dictated by indication. NN was only required to make space for transplantation in one case (combined kidney and pancreas transplant). The main indications for NN were recurrent infection and pain, where NN can provide a successful outcome. Laparoscopic NN can be performed safely in patients with ADPKD. Haematuria in such patients should not be assumed to be of benign origin and requires exclusion of urinary tract malignancy as the incidence of RCC in this population is at least as common as in the general population.

Urinary tract infections, VUR, and autosomal dominant polycystic kidney disease

2003 ◽  
Vol 18 (8) ◽  
pp. 823-825 ◽  
Author(s):  
Oren Koslowe ◽  
Rachel Frank ◽  
Bernard Gauthier ◽  
Marcela Vergara ◽  
Howard Trachtman
Keyword(s):  
Urinary Tract ◽  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Urinary Tract Infections ◽  
Autosomal Dominant ◽  
Polycystic Kidney ◽  
Autosomal Dominant Polycystic Kidney ◽  
Tract Infections
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