Cocaine Exacerbates Hypoxia-lnduced Cell Damage in the Developing Brain: Effects on Ornithine Decarboxylase Activity and Protein Synthesis

Neonatology ◽  
1994 ◽  
Vol 66 (5) ◽  
pp. 254-266 ◽  
Author(s):  
Y.R. Spraggins ◽  
F.J. Seidler ◽  
T.A. Slotkin
Keyword(s):  
Protein Synthesis ◽  
Ornithine Decarboxylase ◽  
Cell Damage ◽  
Developing Brain ◽  
Decarboxylase Activity ◽  
Ornithine Decarboxylase Activity

scholarly journals Control of ornithine decarboxylase activity in stimulated human lymphocytes by putrescine and spermidine

1973 ◽  
Vol 132 (4) ◽  
pp. 791-796 ◽  
Author(s):  
John E. Kay ◽  
Valerie J. Lindsay
Keyword(s):  
Protein Synthesis ◽  
Ornithine Decarboxylase ◽  
Rna Synthesis ◽  
Culture Medium ◽  
Feedback Inhibition ◽  
Human Lymphocytes ◽  
Decarboxylase Activity ◽  
Ornithine Decarboxylase Activity

Ornithine decarboxylase activity in extracts of phytohaemagglutinin-stimulated human lymphocytes is rapidly and extensively inhibited by additions of micromolar concentrations of putrescine or spermidine to the culture medium. This inhibition is not due to feedback inhibition of the enzyme by putrescine, spermidine or their metabolites. Inhibition is dependent on the continuation of protein synthesis, but does not require RNA synthesis. The effect of putrescine is abolished when its conversion into spermidine by the cells is prevented.

scholarly journals Thyroid-hormone effects on ornithine decarboxylase

1980 ◽  
Vol 192 (2) ◽  
pp. 765-767 ◽  
Author(s):  
E W Chideckel ◽  
S J Rozovski ◽  
E R Belur
Keyword(s):  
Protein Synthesis ◽  
Thyroid Hormone ◽  
Ornithine Decarboxylase ◽  
Functional State ◽  
Decarboxylase Activity ◽  
Ornithine Decarboxylase Activity ◽  
Hormone Effects

We examined thyroidectomized, normal and hyperthyroid rats and found that ornithine decarboxylase activity was directly correlated with thyroid functional state in heart and liver and unaffected in brain, testes and spleen, phenomena that correlate with the known effect of thyroid hormone on protein synthesis.

Ornithine Decarboxylase Activity in Cultured Endothelial Cells Stimulated by Serum, Thrombin and Serotonin

1978 ◽  
Vol 39 (02) ◽  
pp. 496-503 ◽  
Author(s):  
P A D’Amore ◽  
H B Hechtman ◽  
D Shepro
Keyword(s):  
Endothelial Cells ◽  
Ornithine Decarboxylase ◽  
Decarboxylase Activity ◽  
Aortic Endothelial Cells ◽  
Ornithine Decarboxylase Activity ◽  
Rate Limiting Step ◽  
Bovine Aortic Endothelial Cells ◽  
Limiting Step ◽  
Rate Limiting ◽  
Serum Serotonin

SummaryOrnithine decarboxylase (ODC) activity, the rate-limiting step in the synthesis of polyamines, can be demonstrated in cultured, bovine, aortic endothelial cells (EC). Serum, serotonin and thrombin produce a rise in ODC activity. The serotonin-induced ODC activity is significantly blocked by imipramine (10-5 M) or Lilly 11 0140 (10-6M). Preincubation of EC with these blockers together almost completely depresses the 5-HT-stimulated ODC activity. These observations suggest a manner by which platelets may maintain EC structural and metabolic soundness.

scholarly journals ORNITHINE DECARBOXYLASE ACTIVITY AS A PROGNOSTIC MARKER FOR COLORECTAL CANCER

2007 ◽  
Vol 53 (1) ◽  
pp. 1-9 ◽  
Author(s):  
YUTAKA HOSHINO ◽  
SHINYA TERASHIMA ◽  
YASUSHI TERANISHI ◽  
MASANORI TERASHIMA ◽  
MICHIHIKO KOGURE ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Marker ◽  
Ornithine Decarboxylase ◽  
Decarboxylase Activity ◽  
Ornithine Decarboxylase Activity
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