scholarly journals Association between Prescription of Conventional or Atypical Antipsychotic Drugs and Mortality in Older Persons with Alzheimer’s Disease

2011 ◽  
Vol 31 (3) ◽  
pp. 218-224 ◽  
Author(s):  
Massimo Musicco ◽  
Katie Palmer ◽  
Antonio Russo ◽  
Carlo Caltagirone ◽  
Fulvio Adorni ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Atypical Antipsychotic ◽  
Older Persons ◽  
Antipsychotic Drugs ◽  
Atypical Antipsychotic Drugs

scholarly journals Effectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer's Disease

2006 ◽  
Vol 355 (15) ◽  
pp. 1525-1538 ◽  
Author(s):  
Lon S. Schneider ◽  
Pierre N. Tariot ◽  
Karen S. Dagerman ◽  
Sonia M. Davis ◽  
John K. Hsiao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Atypical Antipsychotic ◽  
Antipsychotic Drugs ◽  
Atypical Antipsychotic Drugs

Effectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer’s Disease

2018 ◽  
Author(s):  
Adam P. Mecca ◽  
Rajesh R. Tampi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Side Effects ◽  
Adverse Events ◽  
Atypical Antipsychotic ◽  
Clinical Case ◽  
Atypical Antipsychotics ◽  
Antipsychotic Drugs ◽  
Multicenter Trial ◽  
Antipsychotic Treatment

This chapter provides a summary of the Clinical Antipsychotic Trials of Intervention Effectiveness—Alzheimer’s disease (CATIE-AD), a multicenter trial that investigated whether atypical antipsychotics are an effective treatment for psychosis, aggression, or agitation in outpatients with Alzheimer’s disease. The chapter briefly reviews the study design, as well as implications and limitations. A relevant clinical case concludes the chapter. In summary, atypical antipsychotic use for up to 36 weeks did not lead to clinical improvement based on time to discontinuation, or symptom reduction. Risk of discontinuation due to adverse events and side-effects with worse with antipsychotic treatment compared to placebo. In patients with psychosis, agitation, or aggression due to Alzheimer’s disease, the efficacy of atypical antipsychotics is questionable and their use comes with considerable risks of side effects and adverse events.

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