scholarly journals Intrapulmonary Delivery of Human Umbilical Cord Mesenchymal Stem Cells Attenuates Acute Lung Injury by Expanding CD4+CD25+ Forkhead Boxp3 (FOXP3) + Regulatory T Cells and Balancing Anti- and Pro-inflammatory Factors

2011 ◽  
Vol 27 (5) ◽  
pp. 587-596 ◽  
Author(s):  
Jun Sun ◽  
Zhi-Bo Han ◽  
Wenbin Liao ◽  
Shao Guang Yang ◽  
ZhouXin Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Mesenchymal Stem Cells ◽  
Acute Lung Injury ◽  
Regulatory T Cells ◽  
Lung Injury ◽  
Umbilical Cord ◽  
Inflammatory Factors ◽  
Human Umbilical Cord

scholarly journals Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Hua Zhu ◽  
Yi Xiong ◽  
Yunqiu Xia ◽  
Rong Zhang ◽  
Daiyin Tian ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Umbilical Cord ◽  
Human Umbilical Cord ◽  
Therapeutic Effects

scholarly journals Combination therapy of human umbilical cord mesenchymal stem cells and FTY720 attenuates acute lung injury induced by lipopolysaccharide in a murine model

Oncotarget ◽  
2017 ◽  
Vol 8 (44) ◽  
pp. 77407-77414 ◽  
Author(s):  
Zili Zhang ◽  
Wenfei Li ◽  
Zhizhi Heng ◽  
Jing Zheng ◽  
Puyuan Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Acute Lung Injury ◽  
Combination Therapy ◽  
Lung Injury ◽  
Umbilical Cord ◽  
Murine Model ◽  
Human Umbilical Cord

Lung-Resident Mesenchymal Stem Cells Promote Repair of LPS-Induced Acute Lung Injury via Regulating the Balance of Regulatory T cells and Th17 cells

Inflammation ◽  
2018 ◽  
Vol 42 (1) ◽  
pp. 199-210 ◽  
Author(s):  
Linlin Wang ◽  
Meng Shi ◽  
Lin Tong ◽  
Jian Wang ◽  
Shimeng Ji ◽  
...  
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Mesenchymal Stem Cells ◽  
Acute Lung Injury ◽  
Regulatory T Cells ◽  
Lung Injury ◽  
Th17 Cells

scholarly journals Intramyocardial Injected Human Umbilical Cord-Derived Mesenchymal Stem Cells (Hucmscs ) Contribute to the Recovery of Cardiac Function and the Migration of CD4+ T Cells into the Infarcted Heart via CCL5/CCR5 Signaling

2021 ◽  
Author(s):  
Jing Liu ◽  
Xiaoting Liang ◽  
Mimi Li ◽  
Fang Lin ◽  
Xiaoxue Ma ◽  
...  
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Mesenchymal Stem Cells ◽  
Regulatory T Cells ◽  
Cardiac Function ◽  
Umbilical Cord ◽  
Ventricular Remodeling ◽  
Left Ventricular ◽  
Human Umbilical Cord ◽  
Intramyocardial Injection

Abstract Background: Human umbilical cord-derived mesenchymal stem cells (HucMSCs) have been recognized as a promising cell for treating myocardial infarction (MI). Inflammatory response post MI is critical in determining the cardiac function and subsequent adverse left ventricular remodeling. However, the local inflammatory effect of HucMSCs after intramyocardial injection in murine remains unclear. Methods: HucMSCs were cultured and transplanted into the mice after MI surgery. Cardiac function, angiogenesis, fibrosis and hypertrophy, and immune cells infiltration were evaluated between MI-N.S and MI-HucMSC groups. We detected the expression of inflammatory cytokines and their effects on CD4+ T cells migration. Results: HucMSCs treatment can significantly improve the cardiac function and some cells can survive at least 28 days after MI. Intramyocardial administration of HucMSCs also improved angiogenesis and alleviated cardiac fibrosis and hypertrophy. Moreover, we found the much higher numbers of CD4+ T cells and CD4+FoxP3+ regulatory T cells in the heart with HucMSC than that with N.S treatment on day 7 post MI. In addition, the protein level of C-C Motif Chemokine Ligand 5 (CCL5) greatly increased in the HucMSCs treated heart compared to the control. In vitro, HucMSCs inhibited CD4+ T cells migration and addition of CCL5 antibody or C-C Motif Chemokine receptor 5 (CCR5) antagonist significantly reversed this effect. Conclusion: These findings indicated that HucMSCs contributed to cardiac functional recovery and attenuated cardiac remodeling post MI. Intramyocardial injection of HucMSCs upregulated the CD4+FoxP3+ regulatory T cells and contributed to the migration of CD4+ T cells into the injured heart via CCL5/CCR5 pathway.

scholarly journals Human umbilical cord mesenchymal stem cells reduce systemic inflammation and attenuate LPS-induced acute lung injury in rats

2012 ◽  
Vol 9 (1) ◽  
pp. 33 ◽  
Author(s):  
Jianjun Li ◽  
Dong Li ◽  
Xiaomei Liu ◽  
Shuhai Tang ◽  
Fengcai Wei
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Umbilical Cord ◽  
Systemic Inflammation ◽  
Human Umbilical Cord

scholarly journals Exosomal miR-451 from human umbilical cord mesenchymal stem cells attenuates burn-induced acute lung injury

2019 ◽  
Vol 82 (12) ◽  
pp. 895-901 ◽  
Author(s):  
Ji-Song Liu ◽  
Juan Du ◽  
Xiu Cheng ◽  
Xiang-Zhou Zhang ◽  
Yong Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Umbilical Cord ◽  
Human Umbilical Cord
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