scholarly journals A Generalized Sequential Bonferroni Procedure for GWAS in Admixed Populations Incorporating Admixture Mapping Information into Association Tests

2015 ◽  
Vol 79 (2) ◽  
pp. 80-92 ◽  
Author(s):  
Wenan Chen ◽  
Chunfeng Ren ◽  
Huaizhen Qin ◽  
Kellie J. Archer ◽  
Weiwei Ouyang ◽  
...  
2019 ◽  
Author(s):  
Simone Freitag ◽  
Susanne Stolzenburg ◽  
Georg Schomerus ◽  
Silke Schmidt

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Tiana Borgers ◽  
Nathalie Krüger ◽  
Silja Vocks ◽  
Jennifer J. Thomas ◽  
Franziska Plessow ◽  
...  

Abstract Background Fear of weight gain is a characteristic feature of anorexia nervosa (AN), and reducing this fear is often a main target of treatment. However, research shows that 20% of individuals with AN do not report fear of weight gain. Studies are needed that evaluate the centrality of fear of weight gain for AN with a method less susceptible to deception than self-report. Methods We approximated implicit fear of weight gain by measuring implicit drive for thinness using implicit association tests (IATs). We asked 64 participants (35 AN, 29 healthy controls [HCs]) to categorize statements as pro-dieting vs. non-dieting and true vs. false in a questionnaire-based IAT, and pictures of underweight vs. normal-weight models and positive vs. negative words in a picture-based IAT using two response keys. We tested for associations between implicit drive for thinness and explicitly reported psychopathology within AN as well as group differences between AN and HC groups. Results Correlation analyses within the AN group showed that higher implicit drive for thinness was associated with more pronounced eating disorder-specific psychopathology. Furthermore, the AN group showed a stronger implicit drive for thinness than HCs in both IATs. Conclusion The results highlight the relevance of considering fear of weight gain as a continuous construct. Our implicit assessment captures various degrees of fear of weight gain in AN, which might allow for more individually tailored interventions in the future.


Author(s):  
Frank Ecker ◽  
Jennifer Francis ◽  
Per Olsson ◽  
Katherine Schipper

AbstractThis paper investigates how data requirements often encountered in archival accounting research can produce a data-restricted sample that is a non-random selection of observations from the reference sample to which the researcher wishes to generalize results. We illustrate the effects of non-random sampling on results of association tests in a setting with data on one variable of interest for all observations and frequently-missing data on another variable of interest. We develop and validate a resampling approach that uses only observations from the data-restricted sample to construct distribution-matched samples that approximate randomly-drawn samples from the reference sample. Our simulation tests provide evidence that distribution-matched samples yield generalizable results. We demonstrate the effects of non-random sampling in tests of the association between realized returns and five implied cost of equity metrics. In this setting, the reference sample has full information on realized returns, while on average only 16% of reference sample observations have data on cost of equity metrics. Consistent with prior research (e.g., Easton and Monahan The Accounting Review 80, 501–538, 2005), analysis using the unadjusted (non-random) cost of equity sample reveals weak or negative associations between realized returns and cost of equity metrics. In contrast, using distribution-matched samples, we find reliable evidence of the theoretically-predicted positive association. We also conceptually and empirically compare distribution-matching with multiple imputation and selection models, two other approaches to dealing with non-random samples.


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