12. The function regulator in the treatment of dentoalveolar irregularities

Keyword(s):  
1976 ◽  
Vol 3 (2) ◽  
pp. 67-70 ◽  
Author(s):  
H. L. Eirew

The first in a series of articles describing the fabrication and clinical management of the diverse types of function regulator appliances.


1975 ◽  
Vol 68 (3) ◽  
pp. 341-342
Author(s):  
Coenraad F.A. Moorrees
Keyword(s):  

1980 ◽  
Vol 7 (4) ◽  
pp. 179-181
Author(s):  
Sydney Haynes ◽  
Peter Wood
Keyword(s):  

An acute idiopathic oedema of the lips is described in a patient undergoing function regulator treatment. The event was associated with the fitting of the patient's second appliance which was successfully reintroduced following antihistamine therapy.


2012 ◽  
Vol 17 (6) ◽  
pp. 103-110
Author(s):  
Tânia Gnecchi Tanaka ◽  
Fernanda Angelieri ◽  
Lylian Kazumi Kanashiro ◽  
Silvana Bommarito

OBJECTIVE: To analyze the stability of occlusal changes promoted by the Frankel's Functional Regulator 2 (FR-2), in a mean period of 7.16 years post treatment. METHODS: Fifty-four pairs of models were evaluated, from 18 patients treated with FR-2. All patients had Class II, division 1 malocclusion, with initial mean age of 10.77 years and were treated with FR-2 for 18 months. The models were evaluated at the beginning of treatment (T1), at the end (T2) and after 7.16 years post treatment (T3). For occlusal evaluation, the treatment priority index (TPI) was applied on the three analyzed phases. The alterations that occurred between phases were verified with one another through paired Student's t test, with critical value of 0.05. RESULTS: A statistically significant reduction of TPI was verified, from the initial to the final phase of the treatment, reflecting the efficiency of treatment performed with FR-2, specially due to improvement in molar relation, overjet and overbite. Apart from this, the Class II correction remained stable over time. CONCLUSIONS: In this way, it is concluded that the FR-2 appliance showed to be efficient for the dental correction of Class II malocclusion, with stable occlusal results after 7.16 years post treatment.


2018 ◽  
Author(s):  
Ashutosh Kumar ◽  
Rakesh Kumar Majhi ◽  
Tusar Kanta Acharya ◽  
Karl-Heinz Smalla ◽  
Eckart D Gundelfinger ◽  
...  

TRPV4 has been linked with the development of sensory defects, neuropathic pain, neurodegenerative disorders such as Charcot Marie Tooth disease and various muscular dystrophies. In all these cases mitochondrial abnormalities were tagged as cellular hallmarks and such abnormalities have been reported as key factor for the pathophysiological conditions. Mitochondria also have the unique ability to sense and regulate their own temperature. Here, we demonstrate that TRPV4, a thermosensitive ion channels, localizes to a subpopulation of mitochondria in various cell lines, in primary cells and also in sperm cells. Improper expression and/or function of TRPV4 induce several mitochondrial abnormalities such as low oxidative potential, high Ca2+-influx and changes in electron transport chain functions. TRPV4 is also involved in regulation of mitochondrial morphology, smoothness, and fusion-fission events. The C-terminal cytoplasmic region of TRPV4 can localize it to mitochondria and interacts with mitochondrial proteins including Hsp60, Mfn1 and Mfn2. Regulation of mitochondria by TRPV4 may contribute to previously uncharacterized mitochondria-specific functions observed in various cell types. This discovery may help to link TRPV4-mediated channelopathies with mitochondria-mediated diseases.


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