Studies on Glomerular Basement Membrane in Progressive Hereditary Nephritis

2015 ◽  
pp. 68-75 ◽  
Author(s):  
Caroline O. S. Savage ◽  
S. J. Cashman ◽  
C. D. Pusey ◽  
D. J. Evans ◽  
Laure-Helene No�l ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Hereditary Nephritis

Diagnosis of hereditary nephritis by failure of glomeruli to bind anti-glomerular basement membrane antibodies

1980 ◽  
Vol 96 (4) ◽  
pp. 697-699 ◽  
Author(s):  
David L. Olson ◽  
Sudhir K. Anand ◽  
Benjamin H. Landing ◽  
Eva Heuser ◽  
Carl M. Grushkin ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Hereditary Nephritis

scholarly journals Hereditary Nephritis and Thin Glomerular Basement Membrane Lesion

2021 ◽  
pp. 1-10
Author(s):  
Mark A. Lusco ◽  
Agnes B. Fogo
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Type Iv Collagen ◽  
Renin Angiotensin System ◽  
Electron Microscopic Examination ◽  
Electron Microscopic ◽  
Hereditary Nephritis ◽  
Type Iv ◽  
Increased Risk ◽  
Patients At Risk

Hereditary nephritis (HN) and thin glomerular basement membrane (GBM) lesion share a common clinical presentation of persistent hematuria, thin GBM by kidney biopsy electron microscopic examination, and a mutation in type IV collagen. However, the clinical course and treatment for these entities are different with varying patterns of heredity. Ultrastructural examination of a renal biopsy specimen is essential for the morphologic diagnosis of HN and thin GBM lesion, whereas light microscopy may only give limited diagnostic clues. Additional workup including immunostaining for subtypes of type IV collagen may provide further information on underlying genetic mutations. The diagnosis of HN may lead to treatment with renin-angiotensin system blockade in patients at risk of early-onset renal failure to delay progression to end-stage renal disease. Additionally, patients with isolated microscopic hematuria and thin GBM lesion are at increased risk for chronic kidney disease when associated with other comorbidities; those patients should receive regular clinical assessment to prevent renal function decline.

Nonfamilial hematuria associated with glomerular basement membrane alterations characteristic of hereditary nephritis: Comparison with hereditary nephritis

1987 ◽  
Vol 111 (4) ◽  
pp. 519-524 ◽  
Author(s):  
Norishige Yoshikawa ◽  
Soichiro Matsuyama ◽  
Hiroshi Ito ◽  
Hiroshi Hajikano ◽  
Tamotsu Matsuo
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Hereditary Nephritis

Electron microscopic radioautographic studies on the incorporation of 3H proline in the glomerular basement membrane (GBM) in antistreptococcal-cell-membrane (SCM) injected mice

1984 ◽  
Vol 42 ◽  
pp. 188-189
Author(s):  
R.P. Nayyar ◽  
C.F. Lange ◽  
J. L. Borke
Keyword(s):  
Body Weight ◽  
Cell Membrane ◽  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Mesangial Matrix ◽  
Electron Microscopic ◽  
Group A ◽  
Injection Protocol

Streptococcal cell membrane (SCM) antiserum injected mice show a significant thickening of glomerular basement membrane (GBM) and an increase in mesangial matrix within 4 to 24 hours of antiserum administration (1,2,3). This study was undertaken to evaluate the incorporation of 3H proline into glomerular cells and GBM under normal and anti-SCM induced conditions. Mice were administered, intraperitoneally, 0.1 ml of normal or anti-SCM serum followed by a 10 µC/g body weight injection of 3H proline. Details of the preparation of anti-SCM (Group A type 12 streptococcal pyogenes) and other sera and injection protocol have been described elsewhere (2). After 15 minutes of isotope injection a chase of cold proline was given and animal sacrificed at 20 minutes, 1,2,4,8,24 and 48 hours. One of the removed kidneys was processed for immunofluorescence, light and electron microscopic radioautographic studies; second kidney was used for GBM isolation and aminoacid analysis.

Relationship of Glomerular Basement Membrane Alterations to Epithelial Cell Structure and Clinical Parameters in Alport Syndrome

2010 ◽  
Vol 14 (1) ◽  
pp. 22
Author(s):  
Hye Jin Eom ◽  
Seung Jin Hong ◽  
Jae Seung Lee ◽  
Hyeon Joo Jeong ◽  
Youngki Kim ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Alport Syndrome ◽  
Cell Structure ◽  
Clinical Parameters ◽  
Relationship Of

Fibronectin binding to glomerular basement membrane is altered in diabetes

Diabetes ◽  
1987 ◽  
Vol 36 (6) ◽  
pp. 758-763 ◽  
Author(s):  
M. P. Cohen ◽  
R. Saini ◽  
H. Klepser ◽  
L. G. Vasanthi
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Fibronectin Binding

Electron microscopy of renal glomerular basement membrane changes in healthy mice and in spontaneous and nephrotoxic murine nephritis

Pathology ◽  
1969 ◽  
Vol 1 (3) ◽  
pp. 167-175 ◽  
Author(s):  
Pamela J. Russell ◽  
A. Abbot ◽  
J.D. Hicks ◽  
K. Muirden
Keyword(s):  
Electron Microscopy ◽  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Membrane Changes
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