Predictive Value of Second-Trimester Biomarkers and Maternal Features for Adverse Pregnancy Outcomes

2017 ◽  
Vol 42 (4) ◽  
pp. 285-293 ◽  
Author(s):  
Enav Yefet ◽  
Olga Kuzmin ◽  
Naama Schwartz ◽  
Flora Basson ◽  
Zohar Nachum
Keyword(s):  
Pregnancy Outcomes ◽  
Predictive Value ◽  
Adverse Pregnancy Outcomes ◽  
Second Trimester ◽  
Adverse Pregnancy

scholarly journals 885: Predictive value of second trimester biomarkers and maternal features for adverse pregnancy outcomes

2017 ◽  
Vol 216 (1) ◽  
pp. S505-S506
Author(s):  
Enav Yefet ◽  
Olga Kuzmin ◽  
Naama Schwartz ◽  
Flora Basson ◽  
Zohar Nachum
Keyword(s):  
Pregnancy Outcomes ◽  
Predictive Value ◽  
Adverse Pregnancy Outcomes ◽  
Second Trimester ◽  
Adverse Pregnancy

scholarly journals Clinical significance of unexplained elevated maternal serum alpha feto-protein in second trimester of pregnancy

2018 ◽  
Vol 7 (6) ◽  
pp. 2245
Author(s):  
Urmila Karya ◽  
Sweta Kumari ◽  
Anupam Rani ◽  
Shakun Singh
Keyword(s):  
Pregnant Women ◽  
Pregnancy Outcome ◽  
Pregnancy Outcomes ◽  
Predictive Value ◽  
Maternal Serum ◽  
Adverse Pregnancy Outcomes ◽  
Alpha Fetoprotein ◽  
Second Trimester ◽  
Serum Alpha Fetoprotein ◽  
Adverse Pregnancy

Background: Alpha-fetoprotein (AFP) is the major serum protein in the embryonic stage and in the early fetal stage. The aim of this study was to measure maternal serum AFP levels in second trimester between 15-20 weeks of gestation and to determine whether unexplained elevated MSAFP levels is an effective predictor of adverse pregnancy outcome among Indian population.Methods: This study was a prospective observational study, carried out on 400 pregnant women. Maternal serum alpha-fetoprotein (MSAFP) was measured between 15 and 20 weeks of gestation after excluding congenital malformation or birth defects. MSAFP level was determined by using a radio-immunoassay technique. Women with MSAFP level >2.0 MoM was considered as abnormal while MSAFP level≤ 2.0 MoM was considered as normal. All women were followed up till delivery and pregnancy outcomes were noted and compared between two groups.Results: Women with elevated MSAFP had significantly higher adverse pregnancy outcomes (75.4%) compared to women with MSAFP ≤2.0 MoM (26.1%) (p<0.0001 with relative risk of 2.89, 95% confidence interval 2.276 -3.667).Conclusions: Unexplained elevated MSAFP has high sensitivity, specificity, positive predictive value and negative predictive value in predicting adverse pregnancy outcomes. It would, therefore be worthwhile screening pregnant women in second trimester for maternal serum alpha-fetoprotein levels as it would help to identify high risk pregnancies and allow close antenatal survillence for better pregnancy outcome.

Comparison of pregnancy outcomes after second trimester amniocentesis between procedures performed by experts and non-experts

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Tanapak Wisetmongkolchai ◽  
Fuanglada Tongprasert ◽  
Kasemsri Srisupundit ◽  
Suchaya Luewan ◽  
Kuntharee Traisrisilp ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Loss Rate ◽  
Fetal Loss ◽  
Adverse Pregnancy Outcomes ◽  
Expert Group ◽  
Second Trimester ◽  
Single Institution ◽  
Adverse Pregnancy ◽  
In Pregnancy ◽  
Singleton Pregnancies

AbstractObjectivesTo compare the rate of fetal loss in pregnancy after second trimester amniocentesis between procedures performed by experts and non-experts and to assess other pregnancy complications as secondary outcomes.MethodsA retrospective cohort study was performed on singleton pregnancies that underwent mid-trimester amniocenteses in a single institution. The fetal loss rates of procedures performed by experts and non-experts were collected and analyzed. Other adverse pregnancy outcomes were also examined.ResultsIn total, 14,450 amniocenteses were performed during the study period. These included 11,357 (78.6%) procedures in the group expert operators and 3,093 (21.4%) procedures in the group non-expert operators. In the non-expert group, the fetal loss rate was slightly increased but not significantly (p=0.24).In addition, the higher number of spontaneous abortions was associated with blood-stained amniotic fluid sample (p<0.001; RR=9.28). Multiple needle insertions also increased in the non-expert group significantly. However, no difference in pregnancy outcomes was found between in single and multiple needle insertions.ConclusionsThe amniocentesis procedures performed by the non-experts was not increase the fetal loss rate. However, the other adverse pregnancy outcomes, including preterm birth, low birth weight and fetal growth restriction were significantly increased in the non-expert group.

Second trimester biparietal diameter size and the risk of adverse pregnancy outcomes

2011 ◽  
Vol 31 (10) ◽  
pp. 995-998 ◽  
Author(s):  
Vajiheh Marsoosi ◽  
Reihaneh Pirjani ◽  
Ashraf Jamal ◽  
Laleh Eslamian ◽  
Abbas Rahimi-Foroushani
Keyword(s):  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Second Trimester ◽  
Biparietal Diameter ◽  
Adverse Pregnancy

Association between isolated abnormal levels of maternal serum unconjugated estriol in the second trimester and adverse pregnancy outcomes

2015 ◽  
Vol 29 (13) ◽  
pp. 2093-2097 ◽  
Author(s):  
Thaniyaporn Settiyanan ◽  
Chanane Wanapirak ◽  
Supatra Sirichotiyakul ◽  
Fuanglada Tongprasert ◽  
Kasemsri Srisupundit ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Maternal Serum ◽  
Adverse Pregnancy Outcomes ◽  
Second Trimester ◽  
Adverse Pregnancy ◽  
Unconjugated Estriol

scholarly journals Does the Predictive Value of Maternal Serum Alpha-Fetoprotein on Adverse Pregnancy Outcomes Vary by Race/Ethnicity?

2022 ◽  
Vol 226 (1) ◽  
pp. S185-S186
Author(s):  
Kaitlyn Kincaid ◽  
Yuanfan Ye ◽  
Rubymel J. Knupp ◽  
Jeff M. Szychowski ◽  
John Owen ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Predictive Value ◽  
Maternal Serum ◽  
Adverse Pregnancy Outcomes ◽  
Alpha Fetoprotein ◽  
Serum Alpha Fetoprotein ◽  
Race Ethnicity ◽  
Adverse Pregnancy

Prediction of adverse pregnancy outcomes by combinations of first and second trimester biochemistry markers used in the routine prenatal screening of Down syndrome

2010 ◽  
pp. n/a-n/a ◽  
Author(s):  
Tianhua Huang ◽  
Barry Hoffman ◽  
Wendy Meschino ◽  
John Kingdom ◽  
Nanette Okun
Keyword(s):  
Down Syndrome ◽  
Pregnancy Outcomes ◽  
Prenatal Screening ◽  
Adverse Pregnancy Outcomes ◽  
Second Trimester ◽  
Adverse Pregnancy

scholarly journals Abnormal First And Second Trimester Matenal Seum Marker Levels For Aneuploidy Screening And Adverse Pregnancy Outcomes

2021 ◽  
Vol 26 (3) ◽  
pp. 418-425
Author(s):  
Lale Susan Turkgeldi ◽  
Engin Turkgeldi ◽  
Huseyin Kiyak ◽  
NEŞE YÜCEL
Keyword(s):  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Second Trimester ◽  
Aneuploidy Screening ◽  
Adverse Pregnancy
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