scholarly journals A Prospective Study to Evaluate the Effect of Paclitaxel on Cardiac Ejection Fraction

Breast Care ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. 255-259 ◽  
Author(s):  
Mohammed Osman ◽  
Mohammad Elkady
Keyword(s):  
High Risk ◽  
Ejection Fraction ◽  
Prospective Study ◽  
Performance Status ◽  
Primary Objective ◽  
Cardiac Ejection Fraction ◽  
Grade 3 ◽  
A Prospective Study

Background: The primary objective of the study was to evaluate the long-term changes in ejection fraction (EF) associated with paclitaxel infusion. Methods: 50 patients were enrolled in this prospective study between 2011 and 2015. The study design included frequent follow-up visits to the clinic, EF evaluation at baseline, and regular EF assessment by echocardiography for 30 months after treatment. Results: The median baseline EF was 60% (95% confidence interval (CI) 50-80%). At 30 months, the median EF was 48% (95% CI 40-60%; p = 0.03). During the 30-month follow-up, 10 (20%) patients developed grade 1 and 2 cardiotoxicities; none developed grade 3 or 4 cardiotoxicities. Furthermore, paclitaxel cardiotoxicity increased among patients with high-risk features including associated diabetes mellitus, hypertension, prior radiotherapy to the chest wall, performance status of 2, and age > 60 years. Conclusion: Paclitaxel has cardiotoxic effects. Careful monitoring of cardiac function during and after paclitaxel infusion is required in patients with high-risk features.

Complications After the Treatment of Endometrial Cancer: A Prospective Study Using the French-Italian Glossary

2014 ◽  
Vol 24 (3) ◽  
pp. 418-426 ◽  
Author(s):  
Elisa Piovano ◽  
Luca Fuso ◽  
Cinzia Baima Poma ◽  
Annamaria Ferrero ◽  
Stefania Perotto ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
High Risk ◽  
Prospective Study ◽  
Laparoscopic Approach ◽  
Gynecology And Obstetrics ◽  
High Risk Disease ◽  
The Difference ◽  
A Prospective Study

IntroductionThe evaluation of treatment complications is crucial in modern oncology because they heavily influence the every day life of patients. Several authors confirmed the reproducibility of the French-Italian glossary to score the complications in patients with endometrial cancer after radiotherapy (RT), but the treatment of endometrial carcinoma is primarily surgical and chemotherapy is often used for high-risk disease.ObjectivesThis study aimed to analyze the incidence of complications in our patients treated for endometrial cancer and to verify whether the glossary is a suitable instrument in the description of complications after surgery, RT, and chemotherapy.MethodsThe data of patients affected by endometrial cancer treated in the Gynecology and Obstetrics Academic Department, Azienda Ospedaliera Mauriziano Umberto I in Turin from 2000 to 2009 (with surgery alone or integrated treatments) were prospectively collected, and complications were described using the glossary. Every patient included in the analyses had a minimum of 18 months follow-up.ResultsOf the 271 patients, 68 (25%) experienced at least 1 complication with 87 overall complications. Most of the complications were mild (63%) and were found in the urinary (30%) or cutaneous systems (30%). Forty-four (50%) complications appeared within 1 year after treatment, but 9 (10%) complications appeared after 60 months of follow-up. Patients who were submitted to both surgery and RT showed a trend of higher rate of at least 1 complication (19/58 [32.7%]) if compared with surgery alone (36/135 [26.6%]), even if the difference was not statistically significant (P = 0.09). The incidence of complications in patients treated or not with lymphadenectomy was not statistically different (P = 0.088), whereas patients treated with laparotomy had a higher rate of cutaneous complications if compared with the laparoscopic approach (P = 0.018). The glossary included all observed complications.ConclusionsOne every 4 women treated for endometrial cancer develops a complication. Clinicians should check for complications especially after integrated treatments maintaining surveillance even in the long term. The glossary is a comprehensive instrument to describe the complications of endometrial cancer, regardless of the type of treatment delivered.

scholarly journals Long-term Follow-up of Percutaneous Vena Cava Filters: a Prospective Study in 100 Consecutive Patients

2001 ◽  
Vol 21 (5) ◽  
pp. 450-457 ◽  
Author(s):  
J.-M. Schleich ◽  
O. Morla ◽  
M. Laurent ◽  
B. Langella ◽  
J. Chaperon ◽  
...  
Keyword(s):  
Prospective Study ◽  
Vena Cava ◽  
Vena Cava Filters ◽  
Long Term Follow Up ◽  
A Prospective Study

Docusate and Sennosides for Constipation (DRAFT)

2018 ◽  
Author(s):  
Shalini Dalal
Keyword(s):  
Prospective Study ◽  
Clinical Case ◽  
Performance Status ◽  
Hospital Inpatient ◽  
Stool Softener ◽  
Hospice Patients ◽  
A Prospective Study ◽  
Study Intervention ◽  
Inpatient Units

This chapter describes a prospective study that ran from December 2005 to November 2010 using three hospital inpatient units of adding a stool softener, docusate versus placebo, to sennosides alone for the treatment of constipation among hospice patients. Patients were adults admitted to an inpatient hospice program with a Palliative Performance Status 20% or greater. The chapter describes the basics of the study, including funding, year study began, year study was published, study location, who was studied, who was excluded, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, gives a summary and discusses implications, and concludes with a relevant clinical case.

scholarly journals Sa1936 CHALLENGES AND SUCCESS OF INTRAGASTRIC BALLOON THERAPY IN LIVER TRANSPLANT CANDIDATES: A PROSPECTIVE STUDY WITH LONG-TERM FOLLOW-UP

2020 ◽  
Vol 91 (6) ◽  
pp. AB211-AB212
Author(s):  
Veeravich Jaruvongvanich ◽  
Julie Heimbach ◽  
Monika Rizk ◽  
William Sanchez ◽  
John D. Port ◽  
...  
Keyword(s):  
Prospective Study ◽  
Liver Transplant ◽  
Intragastric Balloon ◽  
Long Term Follow Up ◽  
Transplant Candidates ◽  
A Prospective Study
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