Diffuse Large B-Cell Lymphoma of the Lacrimal Sac in a Japanese Patient

Purpose: To report a Japanese patient with diffuse large B-cell lymphoma (DLBCL) in the lacrimal sac. Methods: This is a case report of a 52-year-old Japanese woman who presented with a 3-month history of epiphora on the right side and a 1-month history of swelling on the right medial canthal area. Lacrimal sac irrigation showed patency of the lacrimal drainage system. Imaging studies revealed a lacrimal sac mass with involvement of the nasolacrimal duct. Results: Histopathology and immunohistochemistry of the biopsy specimen revealed DLBCL. Systemic workup revealed no other lesion. The patient received 6 cycles of R-CHOP regimen. After completion of the 5th cycle of R-CHOP, all of the symptoms had resolved. Conclusion: We report a case of DLBCL in the lacrimal sac, which is the most common type of lacrimal sac lymphoma in Japan. Since DLBCL is one of the aggressive types of lymphoma, Japanese patients with lacrimal sac lymphoma tend to have a poor prognosis.

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Case of primary diffuse large B-cell lymphoma of lacrimal sac in a Japanese patient

Clinical Ophthalmology ◽

10.2147/opth.s14675 ◽

2010 ◽

pp. 1351 ◽

Cited By ~ 1

Author(s):

Toshiyuki Oshitari ◽

Kajita ◽

Yotsukura ◽

Asanagi ◽

Baba ◽

...

Keyword(s):

B Cell ◽

Japanese Patient ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Lacrimal Sac ◽

Large B Cell Lymphoma ◽

Large B Cell

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Primary non-Hodgkin diffuse large B-cell lymphoma of the lacrimal sac: a rare case of aggressive tumor and literature review

Medicine and Pharmacy Reports ◽

10.15386/mpr-1926 ◽

2021 ◽

Author(s):

Maria Gabriella Malzone ◽

Marzio Di Meglio ◽

Dario Furgiuele ◽

Nicola Galantuomo ◽

Sabrina Alfano ◽

...

Keyword(s):

B Cell ◽

Cell Lymphoma ◽

Drainage System ◽

B Cell Lymphoma ◽

Lacrimal Sac ◽

Atypical Symptoms ◽

Large B Cell Lymphoma ◽

Aggressive Tumor ◽

The Right ◽

Large B Cell

Primary malignant lymphomas of the lacrimal sac are rare neoplasms. They are mainly B-cell lymphoma with nonspecific and atypical symptoms, which can lead to misdiagnosis and a delay in the appropriate cure. Early diagnosis made by biopsy and the right choice of treatments can increase the chance of survival. We report a case of a non-Hodgkin diffuse large B-cell lymphoma (DLBCL) of the lacrimal sac, involving also the drainage system, in a 77-year-old female. She presented with an epiphora, swelling and a heavy visual impairment at the left eye successfully treated with cycles of polychemotherapy and radiotherapy.

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Primary diffuse large B cell lymphoma (DLBCL) of the prostate presenting with lower urinary tract symptoms (LUTS)

BMJ Case Reports ◽

10.1136/bcr-2020-236280 ◽

2020 ◽

Vol 13 (12) ◽

pp. e236280

Author(s):

Ayesha Nusrat ◽

Syed Muhammad Nazim

Keyword(s):

Urinary Tract ◽

B Cell ◽

Lower Urinary Tract ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Large B Cell Lymphoma ◽

Urinary Tract Symptoms ◽

History Of ◽

Large B Cell ◽

Lower Urinary

Malignant lymphomas of the prostate are very rare tumours and are generally not considered in the clinical or pathological diagnosis of prostatic enlargement. We report a case of a 56-year-old man who presented with long-standing history of low back pain and a 2-month history of voiding lower urinary tract symptoms. He denied any history of urinary retention, trauma, catheterisation or any constitutional symptoms. Examination revealed no lymphadenopathy and hepatosplenomegaly. Digital rectal examination showed an irregular, moderately enlarged nodular prostate. His prostate-specific antigen was 1.54 ng/mL. MRI of the pelvis did not show any focal lesion apart from abnormal signal intensity in the central zone. Bone scan was negative. Transrectal ultrasound-guided prostate biopsy revealed diffuse large B cell lymphoma. Bone marrow biopsy and whole body positron emission tomography/CT were unremarkable. The patient achieved complete remission after receiving six cycles of R-CHOP chemotherapy.

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Diagnostic pitfalls: intramyocardial lymphoma metastasis mimics acute coronary syndrome in a diffuse large B cell lymphoma patient—case report

International Journal of Emergency Medicine ◽

10.1186/s12245-021-00352-x ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Lilla Prenek ◽

Klára Csupor ◽

Péter Beszterczán ◽

Krisztina Boros ◽

Erika Kardos ◽

...

Keyword(s):

B Cell ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Pericardial Fluid ◽

Cardiac Tumors ◽

Lymphoma Patient ◽

Coronary Syndrome ◽

Large B Cell Lymphoma ◽

The Right ◽

Large B Cell

Abstract Background Cardiac tumors are very uncommon compared to other cardiac diseases. Their clinical symptoms can vary from absent to non-specific. The most common symptoms are arrhythmias, blood flow obstruction due to valvular dysfunction, shortness of breath, systemic embolization, and accumulation of pericardial fluid. Hereby, we describe a very rare case of a diffuse large B cell lymphoma patient who presented with the symptoms and signs of acute coronary syndrome (ACS) but the patient’s complaints were caused by his intramyocardial lymphoma metastasis. Case presentation Forty-eight-year-old diffuse large B cell lymphoma patient was admitted to our emergency department with chest pain, effort dyspnea, and fever. The patient had normal blood pressure, blood oxygen saturation, sinus tachycardia, fever, crackles over the left lower lobe, novum incomplete right bundle branch block with Q waves and minor ST alterations, elevated C-reactive protein, high-sensitivity troponin-T, and d-dimer levels. Chest X-ray revealed consolidation on the left side and enlarged heart. Bed side transthoracic echocardiography showed inferior akinesis with pericardial fluid. Coronary angiography showed no occlusion or significant stenosis. Chest computed tomography demonstrated the progression of his lymphoma in the myocardium. He was admitted to the Department of Hematology for immediate chemotherapy and he reached complete metabolic remission, followed by allogeneic hematopoietic stem cell transplantation. Unfortunately, about 9 months later, he developed bone marrow deficiency consequently severe sepsis, septic shock, and multiple organ failure what he did not survive. Conclusions Our case demonstrates a very rare manifestation of a heart metastasis. ACS is an unusual symptom of cardiac tumors. But our patient’s intramyocardial lymphoma in the right atrium and ventricle externally compressed the right coronary artery and damaged the heart tissue, causing the patient’s symptoms which imitated ACS. Fortunately, the quick diagnostics and immediate aggressive chemotherapy provided the patient’s remission and suitability to further treatment.

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170 Primary Breast Lymphoma-Mimicking Inflammatory Breast Disease: A Case Report

British Journal of Surgery ◽

10.1093/bjs/znab134.199 ◽

2021 ◽

Vol 108 (Supplement_2) ◽

Author(s):

R Alam ◽

B Basak ◽

A Ahsan ◽

A S Gupta ◽

S Islam ◽

...

Keyword(s):

Breast Carcinoma ◽

B Cell ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Primary Breast Lymphoma ◽

Palpable Mass ◽

Large B Cell Lymphoma ◽

Breast Lymphoma ◽

History Of ◽

Large B Cell

Abstract Primary breast lymphoma (PBL) is an unusual clinical entity accounting for 0.4–0.5% of all breast neoplasms. The usual presentation includes a painless palpable mass similar to that of breast carcinoma. Diffuse large B-cell lymphoma (DLBCL) is the most common identifiable type of PBL based on the histopathological examination. We report an unusual case of 22 years old Bangladeshi woman presented with a 6-month history of a lump on left breast. Although the lump was initially small, it began a rapid growth after 4 months. The swelling was localized and did not show any skin involvement or discharge and as she didn’t have any positive familial history of breast carcinoma her primary attending physician diagnosed it as a case of breast abscess. When local incision and drainage proved ineffective, she was referred to us. After doing an immunohistochemistry from incisional biopsy the diagnosis was confirmed as Diffuse Large B-cell Lymphoma. The patient was treated initially by chemotherapy with CHOP therapy followed by wide local excision. Early and accurate diagnosis of PBL is crucial for selecting the appropriate MDT treatment strategies to avert potentially harmful surgical interventions.

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