Living-Related Kidney Transplantation in a Patient with Juvenile Nephronophthisis

Nephron ◽  
2020 ◽  
Vol 144 (11) ◽  
pp. 583-588
Author(s):  
Matej Vnučák ◽  
Karol Graňák ◽  
Petra Skálová ◽  
Ľudovít Laca ◽  
Marián Mokáň ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Autosomal Recessive ◽  
Kidney Diseases ◽  
Dominant Mode ◽  
Kidney Donation ◽  
Living Kidney Donation ◽  
Potential Donor ◽  
Living Donor Transplantation ◽  
Recessive Homozygote ◽  
Living Related

Nephronophthisis (NPHP) is an autosomal recessive disease manifesting as tubulointerstitial nephritis uniformly progressing to ESRD in approximately 5–10% patients in childhood. Living donor transplantation is the most beneficial mean of renal replacement therapy compared to other methods. However, living kidney donation is contraindicated in potential donor with diseases of autosomal dominant mode of inheritance potentially leading to kidney failure in future. On the other hand, autosomal recessive genetic kidney diseases, such as NPHP, are not usually contraindication to living kidney donation. Herein, we are reporting related living kidney transplantation with a family history of NPHP form 46-year-old mother (heterozygote) to 17-year-old daughter with (autosomal recessive homozygote) with focus on donor follow-up after nephrectomy.

scholarly journals Barriers to the Donation of Living Kidneys for Kidney Transplantation

2021 ◽  
Author(s):  
Kyungok Min ◽  
Tai Yeon Koo ◽  
Young Hui Hwang ◽  
Jaeseok Yang
Keyword(s):  
Kidney Transplantation ◽  
Living Donor ◽  
Kidney Donation ◽  
Living Kidney Donation ◽  
Donor Kidney ◽  
Related Factors ◽  
Living Donor Transplantation ◽  
Work Up ◽  
Donor Kidney Transplantation ◽  
Living Donor Kidney

Abstract Since the waiting time for deceased donor kidney transplantation continues to increase, living donor kidney transplantation is an important treatment for end stage kidney disease patients. Barriers to living kidney donation have been rarely investigated despite a growing interest in the utilization of living donor transplantation and the satisfaction of donor safety. Here, we retrospectively analyzed 1,658 potential donors and 1,273 potential recipients who visited the Seoul National University Hospital for living kidney transplantation between 2010 and 2017 to study the causes of donation failure. Among 1,658 potential donors, 902 (54.4%) failed to donate kidneys. The average number of potential donors that received work-up was 1.30 ± 0.66 per recipient. Among living donor kidney transplant patients, 75.1% received kidneys after work-up of the first donor and 24.9% needed work-up of two or more donors. Donor-related factors (49.2%) were the most common causes of donation failure, followed by immunologic or size mismatches between donors and recipients (25.4%) and recipient-related factors (16.2%). Interestingly, withdrawal of donation will along with refusal by recipients or family were the commonest causes, suggesting the importance of non-biomedical aspects. The elucidation of the barriers to living kidney donation could ensure more efficient and safer living kidney donation.

scholarly journals Analysis of donor selection for living related kidney transplantation and their postoperative outcome

2002 ◽  
Vol 130 (5-6) ◽  
pp. 193-197
Author(s):  
Visnja Lezaic ◽  
Ljubica Djukanovic ◽  
Dragana Radivojevic-Djokic ◽  
Radmila Blagojevic-Lazic ◽  
Stojanka Ristic ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Selection Procedure ◽  
Postoperative Outcome ◽  
Careful Examination ◽  
Family Relation ◽  
Abo Incompatibility ◽  
Living Donor Transplantation ◽  
Kidney Transplantations ◽  
Living Related ◽  
Drop Outs

Lack of cadaveric organs for transplantation resulted in increased number of living related kidney donors examinations and consequent transplantations in our Department. Donor procedure, selection, drop-outs and final results for living related donors (LRD) were retrospectively analyzed in this paper. Between 1987 and 1994 202 potential LRD were examined. Most of them were females (59%) and about 30% were older than 60 years. The family relation between LRD and recipients were: parents (95%), siblings (3%), grandmother grandfather (1.5%) and uncle (0.5%). Potential LRD were informed on risks advantages and procedure of living donor transplantation. After primary information 26% of potential LRD gave up further examinations. Following immunological and clinical evaluations 48% of LRD actually donated a kidney. The other 26% were excluded during the selection procedure. High immunological risks including ABO incompatibility, HLA mismatches and positive cross match test were the reasons for drop outs of 35 potential LRD (17%). Five more donors were excluded for medical reasons: one because of low creatinine clearance and four because of neoplasms, discovered during examination (kidney, laryngeal, lung). Fourteen transplantation were not realized due to different recipient reasons: 5 of them had clinical contraindications, two died and in 7 cadaveric kidney transplantations were performed. Mild hypertension, coronary disease and diabetes mellitus type 2 were presented in 5 LRD accepted for transplantation. Five more had to be operated before donation (abdominal or urological operation). Early complications after donor nephrectomy were acute renal failure, stress ulcus, pleuropneumonia in three and thromboflebitis in two donors. In conclusion, although kidney transplantation from LRD is highly successful careful examination during selection procedure is indispensable.

scholarly journals The Change in Living Kidney Donation in Women and Men in the United States (2005–2015): A Population-Based Analysis

2018 ◽  
Vol 29 (4) ◽  
pp. 1301-1308 ◽  
Author(s):  
Jagbir Gill ◽  
Yayuk Joffres ◽  
Caren Rose ◽  
Julie Lesage ◽  
David Landsberg ◽  
...  
Keyword(s):  
United States ◽  
The United States ◽  
Population Based ◽  
Kidney Donation ◽  
Living Donation ◽  
Living Kidney Donation ◽  
United States Census ◽  
Longitudinal Changes ◽  
Using Data ◽  
Living Related

The factors underlying the decline in living kidney donation in the United States since 2005 must be understood to inform strategies to ensure access to this option for future patients. Population-based estimates provide a better assessment of donation activity than do trends in the number of living donor transplants. Using data from the Scientific Registry of Transplant Recipients and the United States Census, we determined longitudinal changes in living kidney donation between 2005 and 2015, focusing on the effect of sex and income. We used multilevel Poisson models to adjust for differences in age, race, the incidence of ESRD, and geographic factors (including population density, urbanization, and daily commuting). During the study period, the unadjusted rate of donation was 30.1 and 19.3 per million population in women and men, respectively, and the adjusted incidence of donation was 44% higher in women (incidence rate ratio [IRR], 1.44; 95% confidence interval [95% CI], 1.39 to 1.49). The incidence of donation was stable in women (IRR, 0.95; 95% CI, 0.84 to 1.07) but declined in men (IRR, 0.75; 95% CI, 0.68 to 0.83). Income was associated with longitudinal changes in donation in both sexes, yet donation was stable in the highest two population income quartiles in women but only in the highest income quartile in men. In both sexes, living related donations declined, irrespective of income. In conclusion, living donation declined in men but remained stable in women between 2005 and 2015, and income appeared to have a greater effect on living donation in men.

PO-04 REBOUND WEIGHT GAIN AND BLOOD PRESSURE CONTROL AFTER LIVING KIDNEY DONATION AND KIDNEY TRANSPLANTATION

2016 ◽  
Vol 16 (C) ◽  
pp. 90
Author(s):  
Ekamol Tantisattamo ◽  
Weera Sukhumthammarat ◽  
Prapaipan Putthapiban ◽  
Wasawat Vutthikraivit ◽  
Siwadon Pitukweerakul
Keyword(s):  
Blood Pressure ◽  
Kidney Transplantation ◽  
Weight Gain ◽  
Blood Pressure Control ◽  
Pressure Control ◽  
Kidney Donation ◽  
Living Kidney Donation

scholarly journals Utility of a 24-Hour Urine Collection in Estimating Daily Sodium and Protein Intakes in Living Kidney Donation (P12-058-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Ekamol Tantisattamo ◽  
Natnicha Leelaviwat ◽  
Possawat Vutthikraivit ◽  
Siroj Dejhansathit
Keyword(s):  
Blood Pressure ◽  
Dietary Intake ◽  
Protein Intake ◽  
Kidney Diseases ◽  
Sodium Intake ◽  
Kidney Donation ◽  
Urine Collection ◽  
Living Kidney Donation ◽  
History Of ◽  
Daily Sodium Intake

Abstract Objectives Dietary intake can promote good health including blood pressure control from low sodium intake, slow progression of chronic kidney disease (CKD) from low protein diet. Counseling how to control amount of diet may be unpractical unless there is objective information of consumed nutrient. A 24-hour urine collection can provide information regarding the amount of intake nutrient. We present a case of healthy women comes for a living kidney donor evaluation and 24-hour urine collection showed high daily sodium and protein intake and lowering sodium and protein intake are advice for the patient. Methods A 37-year-old Caucasian woman with a past medical history significant for possible gestational diabetes mellitus comes to pre-living kidney donation clinic. She would like to donate her kidney to her friend who has end-stage renal disease from a lupus nephritis. The patient denies history of kidney diseases, dysuria, gross hematuria, difficulty urination, or history of passing kidney stone. Her weight was 49.4 kg, height was 1.47 m, and body mass index was BMI 22.76 kg/m². Blood pressure was 126/76 mmHg. Serum creatinine was 0.7 mg/dL and blood urea nitrogen was 14 mg/dL. A 24-hour urine collection showed volume of 1.98 L, microalbumin of 0.24 g, creatinine of 0.9 g, urine urea of 10.1 g, and sodium of 174. Results Calculations from the 24-hour urine collection include a daily urinary creatinine excretion of 18.22 mg/kg/day indicating adequately collected urine and creatinine clearance of 89.21 ml/min. Since urine sodium was 174 mmol/day, calculated daily sodium intake was 4 g. Daily protein intake of 16% of daily protein excretion was 11.63 g/day; therefore, daily protein intake was 72.7 g/day or 1.47 g/kg/day. She was advice to decrease amount of daily sodium intake to 62% (2.5 g/day) and protein intake to 68% (1 g/kg/day) of her current daily dietary intake. Conclusions From the 24-hour urine collection, we can estimate 2 important nutrients that our patient took a day. Calculated daily sodium and protein intake were 4 g/day and 1.47 g/kg/day, respectively. These amounts of sodium and protein intake are higher than recommended daily amount for general population. Particularly, for the person who plan to donate their kidney and will have lower than normal renal function after kidney donation, should have more strict diet control. Therefore, calculated amount of daily nutrient intake from a 24-hour urine collection provide practical care and recommendation to person who need dietary guidance with subjective evidence. Funding Sources None.

Living related kidney transplantation in a patient with autosomal-recessive Alport syndrome

2003 ◽  
Vol 17 (s10) ◽  
pp. 4-8 ◽  
Author(s):  
Ken Sakai ◽  
Masaki Muramatsu ◽  
Hidetaka Ogiwara ◽  
Takeshi Kawamura ◽  
Kenji Arai ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Alport Syndrome ◽  
Autosomal Recessive ◽  
Living Related

scholarly journals Evaluation of the Recipient and Donor in Living Kidney Transplantation

2020 ◽  
Vol 95 (4) ◽  
pp. 260-265
Author(s):  
Ha Yeol Park ◽  
Byung Chul Shin
Keyword(s):  
Kidney Transplantation ◽  
Supply And Demand ◽  
Deceased Donor ◽  
Good Health ◽  
Kidney Donation ◽  
Living Kidney Donation ◽  
Number Of Patients ◽  
Stage Renal Disease ◽  
End Stage

Kidney transplantation is the treatment of choice for end-stage renal disease. A successful kidney transplant improves the quality of life and reduces the mortality risk of patients, as compared to maintenance dialysis. The number of patients awaiting kidney transplantation has steadily increased, and the gap between allograft supply and demand continues to widen despite initiatives to expand the use of nonstandard deceased-donor allografts. The use of organs from living donors is one strategy to address the need for transplants. A medical, surgical, and psychosocial evaluation is mandatory prior to living kidney donation to ensure that the donor candidate is in good health and has normal kidney function, is not a risk to the recipient with respect to transmission of infections and malignancy, and will not face unacceptable risks after donation.

scholarly journals Factors Impacting Conversations with Friends and Family about Living Kidney Donation

The Physician ◽  
2021 ◽  
Vol 7 (1) ◽  
pp. 1-7
Author(s):  
Ahmed Ahmed ◽  
Anna Winterbottom ◽  
John Stoves ◽  
Shenaz Ahmed ◽  
Sunil Daga
Keyword(s):  
Kidney Transplantation ◽  
Risk Perception ◽  
South Asian ◽  
Health Professionals ◽  
Living Donor ◽  
Financial Burden ◽  
Cultural Influences ◽  
Kidney Donation ◽  
Medical Mistrust ◽  
Living Kidney Donation

Introduction  Living donor kidney transplantation is the optimal modality of renal replacement therapy for advanced kidney disease. It is associated with superior recipient and graft survival, a better quality of life and self-reported health status compared to dialysis. Living kidney donation occurs less frequently in members of Black, Asian and Minority Ethnic (BAME) communities in Western countries. This scoping review explores the factors affecting the ability of patients (and health professionals) to initiate conversations about living kidney donation with family and friends, with a focus on BAME population groups. Methods  208 published articles were identified from online databases using keywords: ‘barriers’, ‘decision making’, ‘living donor’, and ‘kidney transplantation. Studies limited to donors or involving paediatric recipients were excluded, Results There were 25 studies that met the inclusion criteria. Of these, 21 studies included BAME communities. Participants of South Asian ethnicity were underrepresented. Key themes were; 1) lack of knowledge 2) risk perception 3) fear of financial burden on donors 4) guilt 5) religious and cultural influences and 6) mistrust of the medical establishment. There were noticeable differences in ethnicity, in the level of knowledge, risk perception and fear of financial burden. Religious/cultural reservations and medical mistrust were only reported in people from BAME populations. Two studies explored health professionals’ views. Discussion This literature review has identified different barriers to the pursuit of living kidney donation, some of which are linked to ethnicity. This study informs the development of a patient decision aid to support people to have conversations with potential donors, with a particular focus on South Asian groups, the second largest ethnic group in the UK.

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