Traveling 10-day Waves at Mid-latitudes in the Troposphere and Lower Stratosphere Revealed by Radiosonde Observations and MERRA-2 Data in 2020

Although the characteristics of the traveling 10-day waves (10DWs) above the middle stratosphere have been well explored, little research has been performed on the counterpart in the troposphere and lower stratosphere (TLS). In the present study, we use radiosonde observations and MERRA-2 data in 2020 to characterize traveling 10DWs in mid-latitudes in the TLS. Single-site observations in both hemispheres show that strong 10DW activities are always accompanied by strong eastward jets (10-13 km). MERRA-2 data indicates that in the troposphere the eastward-propagating modes with larger wavenumbers, i.e., E3, E4, E5 and E6 are dominant. While in the lower stratosphere the eastward- and westward-propagating modes with small zonal wavenumbers e.g., 1 and 2, are dominant. Further research on E3, E4, E5 and E6 modes in the troposphere of both hemispheres shows that all the wave activities are positively correlated to the background zonal wind. The refractive index squared reveal that a strong eastward jet is suitable for these four modes to propagate. However, just above the jet, the eastward wind decreases with altitude, and a thick evanescence region emerges above 15 km. E3, E4, E5 and E6 10DWs cannot propagate upward across the tropopause; as such this can explain why these four modes are weak or even indiscernible in the stratosphere and above. In the troposphere, E5 10DW at 32°S is the most dominant mode in 2020. A case study of the anomalously strong E5 10DW activity on May 12, 2020 indicates that the wave amplification resulted from the upward and equatorward transmission of wave energy flows. Moreover, the tropopause and equatorial region can prevent the propagations of wave energy flows of E5 10DW.

Influence of low-Z impurity on the stabilization of m/n = 2/1 tearing/locked modes in EAST

The impact of the low-Z impurity concentration on the modes stabilization has been investigated in the EAST tokamak. Series of tearing modes (TMs) with multiple helicities are excited by the concentration of low-Z (carbon) impurity, and the dominant mode structure is featured by m/n = 2/1 magnetic islands that propagate in electron diamagnetic drift direction (m and n are poloidal and toroidal mode numbers respectively). The m/n = 2/1 locked modes (LMs) can be formed by the redistribution of low-Z impurity concentration, which is unlocked spontaneously for the decreasing of impurity concentration, where the width of magnetic islands can reach w ≅ 5 cm (w/a ≅ 0.1, a is minor radius). The increasing of electromagnetic brake torque is the primary reason for the mode locking, and the 'O'-point of m/n = 2/1 magnetic islands is locked by the tungsten protector limiter (toroidal position: -0.4π ≦ φ ≦ -0.3π) with separation of Δφ ≅ 0. The 3D asymmetric structure of m/n = 2/1 magnetic islands is formed for the interaction with the tungsten protector limiter, and the electromagnetic interaction decreases dramatically for the separation of Δφ ≧ 0.2π. The mechanisms for the mode excitation and locking can be illustrated by the "hysteresis effect" between the low-Z impurity concentration and the width of m/n = 2/1 magnetic islands, namely the growth of magnetic islands is modulated by the low-Z impurity concentration, and the rotation velocity is decelerated accordingly. However, the intrinsic mechanism for the unlocking of m/n = 2/1 LMs is complicated by considering the concentration of the low-Z impurity, and the possible unlocking mechanism is discussed. Therefore, understanding of the relationship between the impurities and magnetic islands is more important for optimizing the control techniques (RMP→LMs, ECRH→NTM, impurity seeding→major collapse, et al).

Tracing the Origin of the RSPO2 Long-Hair Allele and Epistatic Interaction between FGF5 and RSPO2 in Sapsaree Dog

Genetic analysis of the hair-length of Sapsaree dogs, a Korean native dog breed, showed a dominant mode of inheritance for long hair. Genome-Wide Association Study (GWAS) analysis and subsequent Mendelian segregation analysis revealed an association between OXR1, RSPO2, and PKHD1L1 on chromosome 13 (CFA13). We identified the previously reported 167 bp insertion in RSPO2 3’ untranslated region as a causative mutation for hair length variations. The analysis of 118 dog breeds and wolves revealed the selection signature on CFA13 in long-haired breeds. Haplotype analysis showed the association of only a few specific haplotypes to the breeds carrying the 167 bp insertion. The genetic diversity in the neighboring region linked to the insertion was higher in Sapsarees than in other Asian and European dog breeds carrying the same variation, suggesting an older history of its insertion in the Sapsaree genome than in that of the other breeds analyzed in this study. Our results show that the RSPO2 3’ UTR insertion is responsible for not only the furnishing phenotype but also determining the hair length of the entire body depending on the genetic background, suggesting an epistatic interaction between FGF5 and RSPO2 influencing the hair-length phenotype in dogs.

The Rate, Amplitude, and Duration of Outbursts from Class 0 Protostars in Orion

At least half of a protostar’s mass is accreted in the Class 0 phase, when the central protostar is deeply embedded in a dense, infalling envelope. We present the first systematic search for outbursts from Class 0 protostars in the Orion clouds. Using photometry from Spitzer/IRAC spanning 2004 to 2017, we detect three outbursts from Class 0 protostars with ≥2 mag changes at 3.6 or 4.5 μm. This is comparable to the magnitude change of a known protostellar FU Ori outburst. Two are newly detected bursts from the protostars HOPS 12 and 124. The number of detections implies that Class 0 protostars burst every 438 yr, with a 95% confidence interval of 161 to 1884 yr. Combining Spitzer and WISE/NEOWISE data spanning 2004–2019, we show that the bursts persist for more than nine years with significant variability during each burst. Finally, we use 19–100 μm photometry from SOFIA, Spitzer, and Herschel to measure the amplitudes of the bursts. Based on the burst interval, a duration of 15 yr, and the range of observed amplitudes, 3%–100% of the mass accretion during the Class 0 phase occurs during bursts. In total, we show that bursts from Class 0 protostars are as frequent, or even more frequent, than those from more evolved protostars. This is consistent with bursts being driven by instabilities in disks triggered by rapid mass infall. Furthermore, we find that bursts may be a significant, if not dominant, mode of mass accretion during the Class 0 phase.

Lipoprotein(a)—The Crossroads of Atherosclerosis, Atherothrombosis and Inflammation

Increased lipoprotein(a) (Lp(a)) levels are an independent predictor of coronary artery disease (CAD), degenerative aortic stenosis (DAS), and heart failure independent of CAD and DAS. Lp(a) levels are genetically determinated in an autosomal dominant mode, with great intra- and inter-ethnic diversity. Most variations in Lp(a) levels arise from genetic variations of the gene that encodes the apolipoprotein(a) component of Lp(a), the LPA gene. LPA is located on the long arm of chromosome 6, within region 6q2.6–2.7. Lp(a) levels increase cardiovascular risk through several unrelated mechanisms. Lp(a) quantitatively carries all of the atherogenic risk of low-density lipoprotein cholesterol, although it is even more prone to oxidation and penetration through endothelia to promote the production of foam cells. The thrombogenic properties of Lp(a) result from the homology between apolipoprotein(a) and plasminogen, which compete for the same binding sites on endothelial cells to inhibit fibrinolysis and promote intravascular thrombosis. LPA has up to 70% homology with the human plasminogen gene. Oxidized phospholipids promote differentiation of pro-inflammatory macrophages that secrete pro-inflammatory cytokines (e. g., interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α). The aim of this review is to define which of these mechanisms of Lp(a) is predominant in different groups of patients.

Buoyancy-driven algebraic (localised) boundary-layer disturbances

We show that a new class of steady linear eigenmodes exist in the Falkner–Skan boundary layer, associated with an algebraically developing, thermally coupled three-dimensional perturbation that remains localised in the spanwise direction. The dominant mode has a weak temperature difference that decays (algebraically) downstream, but remains sufficient (for favourable pressure gradients that are below a critical level) to drive an algebraically growing disturbance in the velocity field. We determine the critical Prandtl number and pressure gradient parameter required for downstream algebraic growth. We also march the nonlinear boundary-region equations downstream, to demonstrate that growth of these modes eventually gives rise to streak-like structures of order-one aspect ratio in the cross-sectional plane. Furthermore, this downstream flow can ultimately become unstable to a two-dimensional Rayleigh instability at finite amplitudes.

A horizon scanning approach to rapidly detect alien fern species through horticultural trade

Horticultural trade is a well-documented pathway of introduction for numerous invasive species globally, including ferns. In this study, we analysed trade in terrestrial true ferns (Polypodiophyta) in six anglophone countries: Canada (CA), the United States of America (US), Great Britain and Ireland (GB, for ease of reading), South Africa (ZA), Australia (AU), and New Zealand (NZ). The study provides an overview of fern trade and explored the relationship between trade and alien fern introductions with a view to better inform management interventions. Using a horizon scanning approach in consulting horticultural catalogues, we identified a total of 382 fern species currently traded by 148 traders in a period of just six months. International trade was observed in only three countries with most trade occurring at national scales and e-commerce was not the dominant mode of trade noted in this study, with a relatively higher proportion of species traded on-ground. Alien species accounted for more than 60 % of the total number of traded species in most countries except in AU and NZ, and a surprising number of species (11-14 species per country) known to be naturalised or invasive in their country of trade remain actively traded, with fewer species in CA (2) and AU (5). A total of 194 species noted in trade have not previously been recorded as alien in plant species inventories and did not have an invasion status assigned in their countries of trade. We identified 62 species of concern (i.e., potential future invaders) with Dryopteris erythrosora, Anisocampium niponicum, Polystichum polyblepharum, Austroblechnum penna-marina subsp. penna-marina, Asplenium nidus, Dicksonia antarctica, Polypodium vulgare, and Adiantum raddianum indicated as priority species for regulation in trade due to their high market presence. Citizen science records were noted for very few species of concern with only two records indicating the occurrence of two species in natural or semi-natural areas. This research constitutes one of few studies that have applied a horizon scanning approach using horticultural catalogues to identify alien species, and highlights the efficiency of this approach as a tool for the early detection of potentially invasive species.

Rainfall variability and meteorological drought in the Horn of Africa

Basic rainfall characteristics and drought over the Horn of Africa (HoA) is investigated, from 1901 to 2010. Standard Precipitation Index (SPI) is used to study drought variability, mainly focusing on 3-month SPI. The dominant mode of variability of seasonal rainfall was analyzed by performing Empirical orthogonal functions (EOF) analysis. Gridded data is sourced from Climate Research Unit (CRU), spanning from 1901 to 2010. The HoA experiences predominantly bimodal rainfall distribution in time; March to May (MAM) and October to December (OND). The spatial component of the first eigenvector (EOF1) shows that the MAM and OND seasonal rainfalls are dominated by negative and positive loadings, respectively. The EOF1 explain 34.5% and 58.9% variance of MAM and OND seasonal rainfall, respectively. The EOF2, 3 and 4 are predominantly positive, explaining less than 25% in total of the seasonal rainfall variance in the two seasons. The last two decades experienced the highest negative anomaly, with OND seasonal rainfall showing higher anomalies as compared to MAM season. The OND season recorded 9% more drought events as compared to MAM season. The frequency of occurrence of moderate, severe and extreme dryness was almost the same in the two seasons. These results give a good basis for regional model validation, as well as mapping out drought hotspots and projections studies in the HoA.

Vitamin D Metabolic Pathway Genes Polymorphisms and Their Methylation Levels in Association With Rheumatoid Arthritis

Abnormal vitamin D metabolism is involved in the pathogenesis of rheumatoid arthritis (RA). In this study, we evaluated the association of single nucleotide polymorphisms (SNPs) and methylation levels in vitamin D metabolic pathway genes with RA susceptibility. Ten SNPs in vitamin D metabolic pathway genes (CYP2R1, CYP24A1, VDR, CYP27B1) were genotyped in 477 RA patients and 496 controls by improved multiple ligase detection reaction (iMLDR). The methylation levels of the promoter regions of these genes were detected in 122 RA patients and 123 controls using Illumina Hiseq platform. We found that the CYP2R1 rs1993116 GA genotype, CYP27B1 rs4646536 GA genotype, rs4646536 A allele frequencies were significantly increased in RA patients when compared to controls. The decreased risk of rs1993116, rs4646536 was found under the dominant mode in RA patients. However, no significant association was found between CYP2R1 rs7936142, rs12794714, CYP24A1 rs2762934, rs6068816, rs2296239, rs2296241, VDR rs11574129, rs3847987 polymorphism, and RA susceptibility. The VDR, CYP27B1 methylation levels in RA patients were significantly lower than those in controls, while CYP2R1, CYP24A1 methylation levels were not associated with RA. There were no statistical associations between CYP2R1, CYP24A1, VDR, CYP27B1 methylation levels and their respective genotype in RA patients. In addition, plasma 25OHD level in RA patients was significantly lower than that in healthy controls. In summary, our results showed that CYP2R1, CYP27B1 genetic variations were associated with the genetic background of RA, while altered VDR, CYP27B1 methylation levels were related to the risk of RA.

A rare case of a male child with post-zygotic de novo mosaic variant c.538C > T in MECP2 gene: a case report of Rett syndrome

Background Rett syndrome (RTT) is characterized by a normal perinatal period with a normal head size at birth followed by normal development for the first 6 months of life followed by gradual deceleration of head growth, loss of acquired purposeful hand skills, severe expressive and receptive language impairment, severe intellectual disability and gait and truncal apraxia/ ataxia. It is caused due to mutations in the MECP2 gene and follows an X-linked dominant mode of inheritance. It was observed exclusively in females and was believed to be lethal in males. In contrast to this belief, several males were identified with RTT upon genetic analysis, however, most males expired by the age of 2 years due to neonatal encephalopathy. The ones that survived beyond the age of 2 years, were attributed to the presence of an extra X chromosome (co-occurrence of Klinefelter and RTT) or the ones having mosaic cell lines. Only 11 males with somatic mosaicism are known till date. Case presentation This case reports an ultra-rare case of a male affected with RTT surviving beyond the age of 2 years due to post-zygotic de novo somatic mosaicism. He was identified with a known pathogenic variant c.538C > T (p.R180*), which to the best of our knowledge is exclusively seen in females and has never been reported in a male before. Conclusion The present case is the first report of a mosaic male affected with RTT from India. The present report also carried out genotype-phenotype correlations across surviving mosaic males with RTT. We also postulate the effect of variant type, position along the gene and the variant allele fraction in different tissue types to be correlated with disease severity.