Idiopathic Dural Optic Nerve Sheath Calcification Associated with Sclerochoroidal Calcification: Case Report and Review of Literatures

We present a patient with idiopathic intracranial calcifications with simultaneous involvement of sclera, choroid, optic nerve, and trochlear apparatus. A 70-year-old woman with bilateral decreased vision was referred to our hospital. Ocular examinations revealed sclerochoroidal mass beneath superotemporal vascular arcade in macular area. Orbital CT scan shows bilateral calcification of dural optic nerve sheath and posterior wall of the globe as well as calcification in the trochlear apparatus and brain. Ultrasound showed highly reflective echogenic lesion with shadowing. OCT revealed rolling topography with thinning of the overlying choroid and outer nuclear layer as well as absence of the external limiting membrane and inner segment-outer segment junction. Slight irregular thickening of the retinal pigment epithelium is present. It is the first case of simultaneous bilateral dural optic nerve sheath and sclerochoroidal calcification.

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Optical Coherence Tomography Shape Analysis of the Peripapillary Retinal Pigment Epithelium Layer in Presumed Optic Nerve Sheath Meningiomas

Journal of Neuro-Ophthalmology ◽

10.1097/wno.0000000000000107 ◽

2014 ◽

Vol 34 (2) ◽

pp. 130-136 ◽

Cited By ~ 11

Author(s):

Patrick Sibony ◽

Matthew Strachovsky ◽

Robert Honkanen ◽

Mark J. Kupersmith

Keyword(s):

Optical Coherence Tomography ◽

Optic Nerve ◽

Retinal Pigment Epithelium ◽

Shape Analysis ◽

Pigment Epithelium ◽

Retinal Pigment ◽

Optic Nerve Sheath ◽

Optical Coherence ◽

Nerve Sheath ◽

Retinal Pigment Epithelium Layer

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Progressive sixth nerve palsy secondary to intracavernous arachnoid cyst and complicated by contralateral optic nerve sheath meningioma

European Journal of Ophthalmology ◽

10.1177/1120672119853133 ◽

2019 ◽

Vol 30 (5) ◽

pp. NP86-NP89

Author(s):

Kelly A Malloy ◽

Erin M Draper ◽

Ashley K Maglione ◽

Kelly M Seidler

Keyword(s):

Optic Nerve ◽

Arachnoid Cyst ◽

Cranial Nerve ◽

Nerve Palsy ◽

Critical Role ◽

Optic Nerve Sheath ◽

Ocular Motility ◽

Nerve Sheath ◽

First Case ◽

Optic Nerve Sheath Meningioma

Introduction: Optic nerve sheath meningiomas and intracavernous arachnoid cysts are both fairly rare conditions, and to the best of our knowledge, have not been previously reported to co-occur in the same patient. Both can cause diplopia, but only ONSMs have been documented to demonstrate progressive worsening of ocular motility. Case Report: A 67-year-old woman with blur and diplopia demonstrated a right optic neuropathy and limited ductions bilaterally. Neuroimaging revealed a right optic nerve sheath meningioma and left intracavernous arachnoid cyst. She was conservatively managed with neurosurgical surveillance for 1.5 years, until her diplopia worsened. Ocular motility re-evaluation demonstrated a worsening left abduction deficit, suggesting interval change of the intracavernous cyst, rather than the meningioma. Conclusion: There are only a few reported cases of cranial nerve VI palsy secondary to a cavernous sinus arachnoid cyst. However, this is the first reported case in a patient with a concurrent optic nerve sheath meningioma, and the first case demonstrating progressive worsening of a sixth cranial nerve palsy from an intracavernous arachnoid cyst. Determining which comorbidity caused worsening of symptoms played a critical role in the management of this patient.

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Surgical treatment of progressive visual loss in traumatic optic neuropathy

Journal of Neurosurgery ◽

10.3171/jns.1989.70.5.0799 ◽

1989 ◽

Vol 70 (5) ◽

pp. 799-801 ◽

Cited By ~ 29

Author(s):

John Guy ◽

Mark Sherwood ◽

Arthur L. Day

Keyword(s):

Visual Acuity ◽

Optic Nerve ◽

Arachnoid Cyst ◽

Optic Neuropathy ◽

Visual Loss ◽

Optic Nerve Sheath ◽

Traumatic Optic Neuropathy ◽

Axial Tomography ◽

Nerve Sheath ◽

First Case

✓ In two patients with traumatic optic neuropathy progressive visual loss was reversed by surgical decompression of the optic nerve sheath. The first patient with hemorrhage beneath the optic nerve sheath had progressive loss of vision from counting fingers to no light perception within 24 hours after the injury. Surgical evacuation of the hematoma improved visual acuity to 8/30. The second patient had progressive visual loss from 20/20 to 20/400 within the 1st week after injury. Drainage of an arachnoid cyst of the optic nerve sheath improved visual acuity to 20/25. Computerized axial tomography disclosed the hemorrhage in the first case and enlargement of the optic nerve sheath in the second. While the management of traumatic optic neuropathy is controversial, surgical intervention for an arachnoid cyst and hematoma involving the optic nerve is clearly beneficial.

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Comparison of neuroglobin distribution and expression between the retina of the adult Bactrian camel, rabbits and sheep

Medycyna Weterynaryjna ◽

10.21521/mw.6473 ◽

2020 ◽

Vol 76 (11) ◽

pp. 6473-2020

Author(s):

XIAOHUA DU ◽

JAMES BLACKAR MAWOLO ◽

XIA LIU

Keyword(s):

Optic Nerve ◽

Nerve Fiber ◽

Pigment Epithelium ◽

Outer Nuclear Layer ◽

Retinal Pigment ◽

Bactrian Camel ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Adult Sheep ◽

Positive Expression

Neuroglobin (Ngb) is a kind of protein largely expressed in the brain and retina of mammals. Numerous studies have reported on Ngb expression and distribution in mammals but none have compared the expression in the adult Bactrian camel, rabbits, and sheep. The study examined the distribution and expression of Ngb between the retina of adult Bactrian camel, rabbits, and sheep and provides detailed insight on the morphology of these mammals’ retinae. The immunohistochemical staining procedures were performed to detect Ngb distribution and its expression in the retinae of the adult Bactrian camel, rabbits, and sheep. The results showed that strong positive Ngb expression was found in all layers of the Bactrian camel except the outer nuclear layer, while in the rabbit retina, the strong positive expression was observed in the cortex of the optic nerve fiber layer, the retina cells layer, the network layer, the photoreceptor inner segment, and the pigment, while weak positive expression was shown in the retina of the kernel layer, outside the outer nuclear layer of the retina and the light receptor section. In the adult sheep retina, Ngb was solely expressed in the nerve fiber layer, inner and outer plexiform layer, optic nerve, inner and outer limiting membrane, and photoreceptor inner segment, while weak positive expression was shown in the ganglion cell layer and inner nuclear layer. There exist no Ngb positive expression in the photoreceptor outer segment, the outer nuclear layer, and retinal pigment epithelium of the adult sheep retina. The study documented that Ngb may have a significant function in the maintenance of retinal oxygen homeostasis and participation in the repair of light damage. The study also provided detailed references for Ngb physiological function and its relationship to extreme environmental conditions

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