Squamous Cell Carcinoma within a Congenital Nevus Sebaceous: Case Report and Literature Review

Nevus sebaceous (NS) is a benign hamartoma that typically occurs on the head and neck area at birth. Occasionally, secondary neoplasms can develop on top of the original nevus, which usually occur in the middle age. Squamous cell carcinoma (SCC) arising in NS may occur but is very rare. We report the case of a 44-year-old female with an asymptomatic erythematous papule arising within a hairless yellowish plaque on the left parietal area of her scalp for a month. An excisional biopsy was done, and the histopathologic examination revealed SCC arising in the NS.

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Cutaneous squamous cell carcinoma arising in hidradenitis suppurativa: A case report

SAGE Open Medical Case Reports ◽

10.1177/2050313x19847359 ◽

2019 ◽

Vol 7 ◽

pp. 2050313X1984735 ◽

Cited By ~ 2

Author(s):

Catherine F Roy ◽

Simon F Roy ◽

Feras M Ghazawi ◽

Erica Patocskai ◽

Annie Bélisle ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Hidradenitis Suppurativa ◽

Rare Complication ◽

Excisional Biopsy ◽

Necrosis Factor Alpha ◽

Spindle Cells ◽

Poorly Differentiated ◽

Well Differentiated

We present a case of a 64-year-old man who presented with a rapidly growing tumor in the left buttock and intergluteal cleft area, which was affected by hidradenitis suppurativa. The patient was on tumor necrosis factor-alpha inhibitors for hidradenitis suppurativa for 2 years prior to the development of the mass. Initial biopsy of the mass showed a well-differentiated squamous cell carcinoma with spindle cells and positive epithelial immunomarkers. Subsequent excisional biopsy of the tumor showed an infiltrating poorly differentiated squamous cell carcinoma composed of islands of atypical sarcomatoid spindle cells. Squamous cell carcinoma arising in hidradenitis suppurativa is a rare complication which may occur secondary to chronic inflammation and epidermal hyperproliferation in hidradenitis suppurativa–affected areas.

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Squamous Cell Carcinoma Arising at a Skin Graft Donor Site: Case Report and Review of the Literature

Plastic Surgery Case Studies ◽

10.1177/2513826x211008425 ◽

2021 ◽

Vol 7 ◽

pp. 2513826X2110084

Author(s):

Weston Thomas ◽

Kevin Rezzadeh ◽

Kristie Rossi ◽

Ajul Shah

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Cell Carcinoma ◽

Squamous Cell ◽

Skin Graft ◽

Donor Site ◽

Skin Grafting ◽

Excisional Biopsy ◽

Graft Donor ◽

The Right

Introduction: Skin graft reconstruction is a common method of providing wound coverage. Rarely, skin grafting can be associated with the development of squamous cell carcinoma (SCC) in the graft donor site. Case Report: The patient is a 72-year old male with a 15-year history of bilateral hip wounds. He underwent a multitude of treatments previously with failed reconstructive efforts. After presenting to us, he underwent multiple debridements and eventual skin grafting. Within 4 weeks of the final skin graft, a mass developed at the skin graft donor site at the right thigh. Excisional biopsy returned a well differentiated keratinizing SCC. Discussion/Conclusion: This case demonstrates the acute presentation of SCC in a patient following a skin graft without known risk factors. The purpose of this unique case report is to highlight a very rare occurrence of SCC at a skin graft donor site.

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Squamous cell carcinoma of the head and neck: Management after excisional biopsy of a solitary metastatic neck node

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/0360-3016(93)90007-i ◽

1993 ◽

Vol 25 (4) ◽

pp. 619-622 ◽

Cited By ~ 24

Author(s):

Yvonne Mack ◽

James T. Parsons ◽

William M. Mendenhall ◽

Scott P. Stringer ◽

Nicholas J. Cassisi ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Excisional Biopsy ◽

Neck Node

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Basal Cell–Signet-Ring Squamous Cell Carcinoma of the Eyelid

Archives of Pathology & Laboratory Medicine ◽

10.5858/2006-130-393-bcscco ◽

2006 ◽

Vol 130 (3) ◽

pp. 393-396 ◽

Cited By ~ 2

Author(s):

Alan D. Proia ◽

M. Angelica Selim ◽

Jason C. Reutter ◽

John J. Michon

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Basal Cell ◽

Excisional Biopsy ◽

Collision Tumor ◽

Lower Eyelid ◽

Rapid Expansion ◽

Signet Ring ◽

The Right

Abstract A 93-year-old woman developed a mass on her right lower eyelid that was present for more than 6 months but underwent rapid expansion during several weeks prior to her ophthalmological evaluation. Examination revealed an approximately 1.8 cm in diameter, fleshy, fungating growth involving more than 60% of the right lower eyelid. Excisional biopsy disclosed a neoplasm arising from the epidermis composed of adjoining basal cell and signet-ring squamous cell carcinoma, without a transition zone. The cells comprising the basal and squamous cell carcinomas were distinct immunophenotypically, with only the basal cell carcinoma reacting with Ber-EP4 and CAM 5.2 antibodies. To our knowledge, this case represents the first example of a collision tumor composed of basal cell and signet-ring squamous cell carcinoma.

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Squamous Cell Carcinoma Arising From a Nevus Sebaceous in an 11-Year-Old Patient

Dermatologic Surgery ◽

10.1097/dss.0000000000002005 ◽

2020 ◽

Vol 46 (7) ◽

pp. 969-970

Author(s):

Tamar Hajar ◽

Michael Heath ◽

Stephanie Mengden ◽

Sabra Leitenberger

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Nevus Sebaceous

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Significant Neutrophilic Emperipolesis in Squamous Cell Carcinoma

Case Reports in Oncological Medicine ◽

10.1155/2018/1301562 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5 ◽

Cited By ~ 2

Author(s):

Seza Tetikkurt ◽

Faruk Taş ◽

Funda Emre ◽

Şule Özsoy ◽

Zeki Tolga Bilece

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Treatment Response ◽

Squamous Cell ◽

Tumor Recurrence ◽

Neck Region ◽

Excisional Biopsy ◽

Malignant Cell ◽

Antituberculous Treatment

A 53-year-old man was admitted for tooth mobility. A mass was identified at the tooth base by CT. Histopathology of the excisional biopsy revealed a moderately differentiated squamous cell carcinoma. Many intact neutrophils were observed within the malignant cell cytoplasm. The patient underwent partial maxillectomy and bilateral neck dissection. Significant neutrophilic emperipolesis was detected in the resected material. Four tumor recurrences developed in the head and neck region during follow-up. Surgery and chemoradiotherapy was performed. The latest tumor recurrence occurred in the peripharyngeal and the posterior parotideal region. The patient was started on pembrolizumab therapy and nearly complete treatment response occurred. Pembrolizumab was discontinued due to the adrenal insufficiency and pulmonary tuberculosis that developed as a treatment side effect. Pembrolizumab was commenced again when tumor recurrence occurred. The patient is currently alive with ongoing pembrolizumab and antituberculous treatment. We present this case to remark the presence of a significant neutrophilic emperipolesis in the squamous cell carcinoma of the hard palate and maxilla which is rarely encountered. Emperipolesis may predict tumor behavior and the consequences of immune-modulating treatment response in squamous cell carcinomas of the head and neck in regard to the findings of our case.

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Basaloid squamous cell carcinoma of the larynx: case report

ARS Medica Tomitana ◽

10.1515/arsm-2015-0016 ◽

2015 ◽

Vol 21 (1) ◽

pp. 27-31

Author(s):

Oana Cojocaru ◽

Mariana Aschie ◽

Luminita Gentiana Micu ◽

Gabriela Izabela Baltatescu ◽

Antonela Anca Nicolau

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Excisional Biopsy ◽

Basaloid Squamous Cell Carcinoma ◽

Upper Aerodigestive Tract ◽

Immunohistochemical Examination ◽

Ki 67 ◽

Epithelial Marker ◽

Basaloid Squamous

Abstract Basaloid squamous cell carcinoma is a rare variant of squamous cell carcinoma that most often occurs in the upper aerodigestive tract. This type of tumor has an aggressive behavior and usually is diagnosed in the advances stage. The diagnosis of basaloid squamous cell carcinoma is rather difficult and is based on histopathological and immunohistochemical examination. We report a case of laryngeal basaloid squamous cell carcinoma diagnosed by histological examination of a excisional biopsy specimen. The patient was a 57-year old female with a 3 months-history hoarseness and odynophagia. The histopathological aspect was strongly suggestive for BSCC. Immunohistochemical examination has been done using a panel of biomarkers in order to confirm our initial diagnose. The tumors nests were positive for squamous epithelial marker citokeratin 34βE12, AE1/AE3, CK 19 and also p53 and negative for carcinoembryonic antigen (CEA), vimentin and for neuroendocrine markers. Ki- 67 marker was positive in 60% of the tumoral cells. Based on histopathological and immunohistochemical findings, the tumor was diagnosed as basaloid squamous cell carcinoma.

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Squamous Cell Carcinoma Arising in a Nevus Sebaceous of Jadassohn in a 9-Year-Old Girl: Treatment Using Mohs Micrographic Surgery with Literature Review

Dermatologic Surgery ◽

10.1111/j.1524-4725.2010.01611.x ◽

2010 ◽

Vol 36 (7) ◽

pp. 1203-1208 ◽

Cited By ~ 9

Author(s):

MUBA TAHER ◽

CARY FEIBLEMAN ◽

RICHARD BENNETT

Keyword(s):

Squamous Cell Carcinoma ◽

Literature Review ◽

Cell Carcinoma ◽

Squamous Cell ◽

Mohs Micrographic Surgery ◽

Micrographic Surgery ◽

Nevus Sebaceous

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Coexisting Basal Cell Carcinoma and Squamous Cell Carcinoma in Congenital Nevus Sebaceous

SKIN The Journal of Cutaneous Medicine ◽

10.25251/skin.2.3.6 ◽

2018 ◽

Vol 2 (3) ◽

pp. 181-185

Author(s):

Jordan Rosen ◽

Katherine Nolan ◽

Noah Shaikh ◽

Les Rosen ◽

Martin Zaiac

Keyword(s):

Squamous Cell Carcinoma ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Basal Cell ◽

Squamous Cell Carcinomas ◽

Malignant Neoplasms ◽

Rare Occurrence ◽

Unique Case ◽

Nevus Sebaceous

Nevus sebaceous is a congenital epidermal hamartoma characterized by hyperplastic changes to the epidermis and adnexa. Nevus sebaceous is associated with an elevated risk of cutaneous neoplasms, most often benign; however, malignant neoplasms, most notably basal cell carcinoma, can also present in these patients. Although a rare occurrence, more often affecting adult patients, squamous cell carcinomas have also been reported to arise at the site of pre-existing nevus sebaceous. Herein we report a unique case of a patient with basal cell carcinoma and squamous cell carcinoma arising concurrently in the same nevus sebaceous.

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