The Lipoprotein Lipase
            Hin
            dIII Polymorphism Modulates Plasma Triglyceride Levels in Visceral Obesity

The present studies were designed to delineate changes in heart and adipose tissue lipoprotein lipase (LPL) activity following the administration of E. coli endotoxin. Plasma triglyceride levels were elevated in animals given endotoxin compared to saline-injected controls. Heart LPL activity decreased from 126.4 mumol fatty acid released per gram wet wt per hour in control rats to less than 22.5 mumol . g-1 . h-1 by 7 h following the injection of endotoxin. Although endotoxin was administered in doses producing 0-100% mortalities in a 24-h period, myocardial LPL activity was depressed to the same extent (75-80%) regardless of dose. The response of adipose tissue was less pronounced. Epididymal fat pad LPL activity fell significantly over the 24-h observation period in control and endotoxin-treated rats with the latter group somewhat more depressed 7 h after treatment. The findings are consistent with the suggestion that hypertriglyceridemia often observed during endotoxic shock may be related to depressed LPL activity; the degree of depression is probably tissue dependent.

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A Common Mutation in the Lipoprotein Lipase Gene Promoter, −93T/G, Is Associated With Lower Plasma Triglyceride Levels and Increased Promoter Activity In Vitro

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/01.atv.17.10.1969 ◽

1997 ◽

Vol 17 (10) ◽

pp. 1969-1976 ◽

Cited By ~ 28

Author(s):

Stephen Hall ◽

Grace Chu ◽

George Miller ◽

Kennedy Cruickshank ◽

Jaqueline A. Cooper ◽

...

Keyword(s):

Lipoprotein Lipase ◽

Promoter Activity ◽

Gene Promoter ◽

Plasma Triglyceride ◽

Common Mutation ◽

Lower Plasma ◽

Lipase Gene ◽

Lipoprotein Lipase Gene

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Gene environment interaction and plasma triglyceride levels: the crucial role of lipoprotein lipase

Clinical Genetics ◽

10.1111/j.1399-0004.1994.tb04197.x ◽

2008 ◽

Vol 46 (1) ◽

pp. 15-18 ◽

Cited By ~ 6

Author(s):

Michael R. Hayden ◽

Ming-Sun Liu ◽

Yuanhong Ma

Keyword(s):

Lipoprotein Lipase ◽

Crucial Role ◽

Plasma Triglyceride ◽

Environment Interaction ◽

Gene Environment Interaction ◽

Gene Environment

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Effect of exercise on lipoprotein lipase activity in rat heart and skeletal muscle

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1975.229.2.394 ◽

1975 ◽

Vol 229 (2) ◽

pp. 394-397 ◽

Cited By ~ 57

Author(s):

J Borensztajn ◽

MS Rone ◽

SP Babirak ◽

JA McGarr ◽

LB Oscai

Keyword(s):

Skeletal Muscle ◽

Lipoprotein Lipase ◽

Lipase Activity ◽

Plasma Triglyceride ◽

Treadmill Running ◽

Muscle Fiber Types ◽

Fiber Types ◽

Lipoprotein Lipase Activity ◽

Slow Twitch ◽

Fast Twitch

Lipoprotein lipase activity was measured in the three skeletal muscle fiber types of untrained rats and in those of rats subjected to a 12-wk program of treadmill running. Lipoprotein lipase activity in slow-twitch red fibers was approximately 14- to 20-fold higher (P less than 0.001) than that in fast-twitch white and approximately 2-fold higher (P less than 0.001) than that in fast-twitch red fibers in the untrained animals. These results suggest that, in sedentary animals, mainly slow-twitch red and fast-twitch red fibers are capable of taking up plasma triglyceride fatty acids. Regularly performed endurance exercise resulted in significant increase (2- to 4.5-fold) in lipoprotein lipase activity in the three muscle fiber types examined. The increase in lipoprotein lipase activity in response to treadmill running suggests that exercise increases the capacity of these fibers to take up and oxidize plasma triglyceride fatty acids. Cardiac muscle did not undergo an exercise-induced increase in the levels of activity of lipoprotein lipase similar to that seen in skeletal muscle.

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