Absence of Age-Related Increase in Central Arterial Stiffness in Physically Active Women

Aim. To analyze if childhood obesity associates with changes in elastic, transitional, and/or muscular arteries’ stiffness.Methods. 221 subjects (4–15 years, 92 females) were assigned to normal weight (NW,n=137) or obesity (OB,n=84) groups, considering their body mass indexz-score. Age groups were defined: 4–8; 8–12; 12–15 years old. Carotid, femoral, and brachial artery local stiffness was determined through systodiastolic pressure-diameter and stress-strain relationships. To this end, arterial diameter and peripheral and aortic blood pressure (BP) levels and waveforms were recorded. Carotid-femoral, femoropedal, and carotid-radial pulse wave velocities were determined to evaluate aortic, lower-limb, and upper-limb regional arterial stiffness, respectively. Correlation analysis between stiffness parameters and BP was done.Results. Compared to NW, OB subjects showed higher peripheral and central BP and carotid and femoral stiffness, reaching statistical significance in subjects aged 12 and older. Arterial stiffness differences disappeared when levels were normalized for BP. There were no differences in intrinsic arterial wall stiffness (elastic modulus), BP stiffness relationships, and regional stiffness parameters.Conclusion. OB associates with BP-dependent and age-related increase in carotid and femoral (but not brachial) stiffness. Stiffness changes would not be explained by intrinsic arterial wall alterations but could be associated with the higher BP levels observed in obese children.

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Abstract 125: Elevated Muscle Sympathetic Nerve Activity is Associated With Higher Aortic and Carotid Stiffness Independent of Blood Pressure in Women

Hypertension ◽

10.1161/hyp.70.suppl_1.125 ◽

2017 ◽

Vol 70 (suppl_1) ◽

Author(s):

Seth W Holwerda ◽

Rachel E Luehrs ◽

Nealy A Wooldridge ◽

Lyndsey E DuBose ◽

Jess G Fiedorowicz ◽

...

Keyword(s):

Blood Pressure ◽

Arterial Stiffness ◽

Sympathetic Nerve ◽

Sympathetic Nerve Activity ◽

Muscle Sympathetic Nerve Activity ◽

Strongly Correlated ◽

Nerve Activity ◽

Arterial Blood ◽

Age Related ◽

Related Increase

Central arterial stiffness, a significant contributor to the development of hypertension and cardiovascular disease with aging, is linked to elevated muscle sympathetic nerve activity (MSNA) in men. However, the extent to which MSNA is associated with central arterial stiffness in women is unknown. Given that the age-related increase in MSNA and arterial blood pressure (BP) occurs at a steeper rate among women compared to men, we tested the hypothesis that resting MSNA is more strongly correlated with central arterial stiffness in women than in men. Also, because of the parallel age-related increase in MSNA, we further hypothesized that the relation between MSNA and central arterial stiffness would not be independent of age. MSNA (microneurography), aortic stiffness (carotid-femoral pulse wave velocity, CFPWV), and carotid β-stiffness (carotid tonometry and ultrasound) were assessed in 54 healthy men (n=29; 19-72 yrs; 30 ± 1 kg/m 2 ; systolic BP: 128 ± 3 mmHg) and women (n=26; 26-64 yrs; 29 ± 2 kg/m 2 ; systolic BP: 116 ± 3 mmHg). No differences between men and women were observed for CFPWV (Men: 7.0 ± 0.3 vs. Women: 6.8 ± 0.4 mmHg, P=0.747) and carotid β-stiffness (Men: 7.6 ± 0.8 vs. Women: 7.6 ± 0.5 mmHg, P=0.975). Mean BP was lower in women compared to men (Men: 93 ± 3 vs. Women: 85 ± 2 mmHg, P=0.021) and MSNA tended to be lower in women compared to men (Men: 25 ± 3 vs. Women: 20 ± 2 bursts/min, P=0.091). After adjusting for mean BP and HR (partial correlation), CFPWV was significantly correlated with MSNA in men (R=0.44, P=0.021) and women (R=0.58, P=0.004). Interestingly, further adjustment for age abolished the association between CFPWV and MSNA in men (R=0.01, P=0.968), but not in women (R=0.43, P=0.046). A moderate relation between carotid β-stiffness and MSNA was observed in men (R=0.37, P=0.063) and women (R=0.44, P=0.034), but was abolished after adjusting for age (Men: R=-0.001, P=0.995; Women: R=0.26, P=0.245). These preliminary data demonstrate that MSNA is positively correlated with central arterial stiffness in women and men independent of BP. Furthermore, abolishment of the relation between MSNA and CFPWV in men only when adjusting for age suggests that the association between MSNA and central arterial stiffness may be more robust in women.

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Age-Related Increase in Alanine Aminotransferase Correlates with Elevated Levels of Plasma Amino Acids, Decanoylcarnitine, Lp-PLA2 Activity, Oxidative Stress, and Arterial Stiffness

Journal of Proteome Research ◽

10.1021/pr500422z ◽

2014 ◽

Vol 13 (7) ◽

pp. 3467-3475 ◽

Cited By ~ 10

Author(s):

Saem Jung ◽

Oh Yoen Kim ◽

Minjoo Kim ◽

Juheui Song ◽

Sang-Hyun Lee ◽

...

Keyword(s):

Oxidative Stress ◽

Amino Acids ◽

Arterial Stiffness ◽

Alanine Aminotransferase ◽

Plasma Amino Acids ◽

Pla2 Activity ◽

Age Related ◽

Related Increase

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Influence of Regular Exercise on Age-Related Changes in Arterial Elasticity: Mechanistic Insights From Wall Compositions in Rat Aorta

Canadian Journal of Applied Physiology ◽

10.1139/h03-016 ◽

2003 ◽

Vol 28 (2) ◽

pp. 204-212 ◽

Cited By ~ 40

Author(s):

Toshiya Nosaka ◽

Hirofumi Tanaka ◽

Izumi Watanabe ◽

Masaaki Sato ◽

Mitsuo Matsuda

Keyword(s):

Elastic Modulus ◽

Arterial Stiffness ◽

Arterial Wall ◽

Rat Aorta ◽

Regular Exercise ◽

Age Related ◽

Significant Difference ◽

Activity Groups ◽

Age Related Changes ◽

Related Increase

Arterial stiffness increases with age in healthy sedentary adults. We previously reported that the age-related increases in arterial stiffness are absent or attenuated in regularly exercising adults. However, the mechanism underlying this training effect is unknown. One possibility is that regular exercise minimizes age-related changes in the arterial wall composition of elastin and collagen. To gain insight into this issue, we studied four groups of rats (N = 23): young (42-46 wks) and old (80-84 wks), sedentary and exercise-trained. The exercise group swam 1 hr•d−1, 6 d•wk−1 for 17-21 weeks. There was no significant difference in the incremental elastic modulus between young sedentary and exercise-trained rats. The elastic moduli of the old exercise-trained rats were 31% lower than in the old sedentary controls. As such, the magnitude of age-related increase in the elastic modulus was smaller in the exercise-trained (110%) vs. the sedentary group (151%) (p < 0.05). In both activity groups, elastin content was lower and collagen content was higher in old vs. young rats (p < 0.05). However, there were no significant differences between the two activity groups. These results are not consistent with the hypothesis that regular physical exercise minimizes age-related compositional changes in the arterial wall and attenuates the age-related increase in arterial stiffness. Key words: elastin, collagen, exercise training

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The Age-Related Increase in Arterial Stiffness Is Augmented in Phases According to the Severity of Hypertension

Hypertension Research ◽

10.1291/hypres.27.465 ◽

2004 ◽

Vol 27 (7) ◽

pp. 465-470 ◽

Cited By ~ 46

Author(s):

Hirofumi TOMIYAMA ◽

Tomio ARAI ◽

Yutaka KOJI ◽

Minoru YAMBE ◽

Kohki MOTOBE ◽

...

Keyword(s):

Arterial Stiffness ◽

Age Related ◽

Related Increase

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Menopause is an independent factor augmenting the age-related increase in arterial stiffness in the early postmenopausal phase

Atherosclerosis ◽

10.1016/j.atherosclerosis.2005.03.043 ◽

2006 ◽

Vol 184 (1) ◽

pp. 137-142 ◽

Cited By ~ 92

Author(s):

Gulnisa Zaydun ◽

Hirofumi Tomiyama ◽

Hideki Hashimoto ◽

Tomio Arai ◽

Yutaka Koji ◽

...

Keyword(s):

Arterial Stiffness ◽

Independent Factor ◽

Age Related ◽

Related Increase

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Longitudinal interaction between APOA5 -1131T>C and overweight in the acceleration of age-related increase in arterial stiffness through the regulation of circulating triglycerides

Hypertension Research ◽

10.1038/s41440-018-0137-y ◽

2018 ◽

Vol 42 (2) ◽

pp. 241-248 ◽

Cited By ~ 2

Author(s):

Minjoo Kim ◽

Hye Jin Yoo ◽

Hwa Jin Lee ◽

Jong Ho Lee

Keyword(s):

Arterial Stiffness ◽

Age Related ◽

Related Increase

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The Association Between Cardio-Ankle Vascular Index and Primary Idiopathic Complete Atrioventricular Block in an Elderly Population

Angiology ◽

10.1177/00033197211028780 ◽

2021 ◽

pp. 000331972110287

Author(s):

Turhan Turan ◽

Faruk Kara ◽

Selim Kul ◽

Muhammet Rasit Sayın ◽

Sinan Sahin ◽

...

Keyword(s):

Arterial Stiffness ◽

Atrioventricular Block ◽

Elderly Population ◽

Complete Atrioventricular Block ◽

Age Related ◽

And Gender ◽

The Relationship ◽

Block Frequency ◽

Complete Atrioventricular ◽

Relevant Factors

The most common cause of complete atrioventricular block (CAVB) is age-related fibrotic degeneration and is referred to as primary idiopathic complete atrioventricular block (iCAVB). This study aims to investigate the relationship between iCAVB and arterial stiffness using the cardio-ankle vascular index (CAVI). In this study, of 205 CAVB patients, 41 patients with iCAVB implanted with a dual-chamber permanent pacemaker and 40 age- and gender-matched controls were studied. Arterial stiffness was assessed by a VaSera VS-1000 CAVI instrument. The CAVI values of patients with iCAVB were significantly higher compared with the controls (9.63 ± 1.42 vs 8.57 ± 1.12, P < .001). Idiopathic complete atrioventricular block frequency was higher among patients with abnormal CAVI values than those with borderline and normal CAVI ( P = .04). In multivariate analysis, only CAVI was an independent predictor of iCAVB after adjusting for other relevant factors (odds ratio, 2.575; 95% CI [1.390-4.770]; P = .003). The present study demonstrated that CAVI, as a marker of arterial stiffness, was increased among elderly patients with iCAVB. Thus, we provide a possible additional mechanism linking easily measured CAVI with iCAVB.

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