scholarly journals Estrogen Increases Endothelial Nitric Oxide Synthase via Estrogen Receptors in Rat Cerebral Blood Vessels

Stroke ◽  
2002 ◽  
Vol 33 (6) ◽  
pp. 1685-1691 ◽  
Author(s):  
Anne Marie McNeill ◽  
Chunying Zhang ◽  
Frank Z. Stanczyk ◽  
Sue P. Duckles ◽  
Diana N. Krause
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Estrogen Receptors ◽  
Blood Vessels ◽  
Endothelial Nitric Oxide Synthase ◽  
Cerebral Blood Vessels ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals Transient Focal Ischemia Increases Endothelial Nitric Oxide Synthase in Cerebral Blood Vessels

Stroke ◽  
2002 ◽  
Vol 33 (11) ◽  
pp. 2704-2710 ◽  
Author(s):  
Roland Veltkamp ◽  
Nishadi Rajapakse ◽  
Greg Robins ◽  
Michelle Puskar ◽  
Katsuyoshi Shimizu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Blood Vessels ◽  
Endothelial Nitric Oxide Synthase ◽  
Focal Ischemia ◽  
Cerebral Blood Vessels ◽  
Transient Focal Ischemia ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals Acetylcholine-induced relaxation in blood vessels from endothelial nitric oxide synthase knockout mice

1999 ◽  
Vol 126 (1) ◽  
pp. 219-226 ◽  
Author(s):  
Thierry Chataigneau ◽  
Michel Félétou ◽  
Paul L Huang ◽  
Mark C Fishman ◽  
Jacques Duhault ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Blood Vessels ◽  
Knockout Mice ◽  
Endothelial Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals Expression of endothelial nitric oxide synthase in the ovine ovary throughout the estrous cycle

Reproduction ◽  
2006 ◽  
Vol 132 (4) ◽  
pp. 579-587 ◽  
Author(s):  
Anna T Grazul-Bilska ◽  
Chainarong Navanukraw ◽  
Mary Lynn Johnson ◽  
Daniel A Arnold ◽  
Lawrence P Reynolds ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Blood Vessels ◽  
Estrous Cycle ◽  
Endothelial Nitric Oxide Synthase ◽  
Follicular Growth ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Enos Protein Expression ◽  
Enos Protein

This study was conducted to evaluate the expression of endothelial nitric oxide synthase (eNOS) in ovarian follicles and corpora lutea (CL) throughout the estrous cycle in sheep. Three experiments were conducted to (1) immunolocalize eNOS protein, (2) determine expression of mRNA for eNOS and its receptor guanylate cyclase 1 soluble β3 (GUCY1B3), and (3) co-localize eNOS and vascular endothelial growth factor (VEGF) proteins in the follicles and/or CL throughout the estrous cycle. In experiment 1, ovaries were collected from ewes treated with FSH, to induce follicular growth or atresia. In experiment 2, ovaries were collected from ewes treated with FSH and hCG to induce follicular growth and ovulation. In experiment 3, ovaries were collected from superovulated ewes to generate multiple CL on days 2, 4, 10, and 15 of the estrous cycle. In experiments 1 and 2, the expression of eNOS protein was detected in the blood vessels of the theca externa and interna of healthy ovarian follicles. However, in early and advanced atretic follicles, eNOS protein expression was absent or reduced. During the immediate postovulatory period, eNOS protein expression was detected in thecal-derived cells that appeared to be invading the granulosa layer. Expression of eNOS mRNA tended to increase in granulosa cells at 12 and 24 h, and in theca cells 48 h after hCG injection. In experiment 3, eNOS protein was located in the blood vessels of the CL during the estrous cycle. Dual localization of eNOS and VEGF proteins in the CL demonstrated that both were found in the blood vessels.

scholarly journals Plasma Membrane Estrogen Receptors Are Coupled to Endothelial Nitric-oxide Synthase through Gαi

2001 ◽  
Vol 276 (29) ◽  
pp. 27071-27076 ◽  
Author(s):  
Myra H. Wyckoff ◽  
Ken L. Chambliss ◽  
Chieko Mineo ◽  
Ivan S. Yuhanna ◽  
Michael E. Mendelsohn ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Plasma Membrane ◽  
Nitric Oxide Synthase ◽  
Estrogen Receptors ◽  
Endothelial Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Localization of endothelial nitric oxide synthase in the normal and failing human atrial myocardium

1996 ◽  
Vol 54 ◽  
pp. 786-787
Author(s):  
Chi-Ming Wei ◽  
Margarita Bracamonte ◽  
Shi-Wen Jiang ◽  
Richard C. Daly ◽  
Christopher G.A. McGregor ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Heart Failure ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Cardiac Tissues ◽  
Mammalian Tissues ◽  
End Stage Heart Failure ◽  
End Stage ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Nitric oxide (NO) is a potent endothelium-derived relaxing factor which also may modulate cardiomyocyte inotropism and growth via increasing cGMP. While endothelial nitric oxide synthase (eNOS) isoforms have been detected in non-human mammalian tissues, expression and localization of eNOS in the normal and failing human myocardium are poorly defined. Therefore, the present study was designed to investigate eNOS in human cardiac tissues in the presence and absence of congestive heart failure (CHF).Normal and failing atrial tissue were obtained from six cardiac donors and six end-stage heart failure patients undergoing primary cardiac transplantation. ENOS protein expression and localization was investigated utilizing Western blot analysis and immunohistochemical staining with the polyclonal rabbit antibody to eNOS (Transduction Laboratories, Lexington, Kentucky).

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