Abstract 17116: Recurrent Atrial Myxomas As A Presenting Feature Of Carney Complex

Circulation ◽  
2021 ◽  
Vol 144 (Suppl_2) ◽  
Author(s):  
Mustafa Alam ◽  
Tavleen Singh ◽  
Anandbir Bath ◽  
Shadwan Alsafwah
Keyword(s):  
Adrenal Insufficiency ◽  
Left Atrial ◽  
Interatrial Septum ◽  
Carney Complex ◽  
Decompressive Hemicraniectomy ◽  
Left Atrial Myxoma ◽  
Atrial Mass ◽  
Café Au Lait Spots ◽  
Upper And Lower Extremities ◽  
History Of

Case Presentation: A 24-year-old man with a history of adrenal insufficiency on hydrocortisone presented to the hospital after losing consciousness in a swimming pool and was found to have an acute MCA stroke. PMHx was significant for left atrial myxoma status post resection 3 years ago, known L frontal brain, L adrenal, and testicular masses status post-resection. His father had a history of resected left atrial mass. Cardiology was consulted for a L atrial mass on the bedside echocardiogram upon initial emergency evaluation, during which the patient was placed on mechanical ventilation with stable vitals. The cardiovascular exam revealed a midsternal scar but was otherwise normal. Pulses were 2+ bilaterally on the upper and lower extremities. The skin was noted to have multiple hyperpigmented macules resembling cafe-au lait spots. The patient underwent mechanical thrombectomy with thrombolysis for his large MCA occlusion. His postoperative course was complicated by a worsening neuro exam in the setting of mid-line shift for which he had undergone decompressive hemicraniectomy. His adrenal insufficiency was managed by endocrinology. A TTE was significant for a L atrial mass measuring 4.8 cm attached to the interatrial septum with a stalk. A CT scan identified 2 discrete hypodensities of 8 mm and 3.8 cm which were thought to be the cardioembolic source for the stroke. An abdominal CT revealed a recurrent L adrenal neoplasm with absent R adrenal gland post resection of neoplasm. Conservative cardiac management was elected in the setting of a worsening neuroprognosis with follow-up post neurologic insult. Discussion: Considering the constellation of neoplastic and cutaneous findings, this was diagnosed as a case of Carney complex. This case identifies recurrent myxoma as a unique feature of Carney complex, ruling out other differentials such as neurofibromatosis and MEN syndrome. It highlights the importance of screening to prevent embolic stroke from recurrent myxomas.

scholarly journals Not a Coincidental Concurrence of Breast Carcinoma and Cardiac Myxoma: Case Report

2021 ◽  
Author(s):  
Ling-Yun Kong ◽  
Wei Xiang ◽  
Ling-Ling Chen ◽  
Dong-Yan Shen ◽  
Fang Liu
Keyword(s):  
Left Atrial ◽  
Cardiac Myxoma ◽  
Interatrial Septum ◽  
Left Breast ◽  
Carney Complex ◽  
Atrial Mass ◽  
Mitral Orifice ◽  
Breast Nodule ◽  
Benign Process ◽  
Diastolic Murmur

Abstract Background: Myxoma has been considered to undergo a simple and benign process but not always so. Case presentation: A female patient was admitted for evaluation of left breast nodule. Physical examination showed facial pigmentation, left breast nodule and 3/6 diastolic murmur at the mitral valve area. Preoperative echocardiography revealed a massive mobile left atrial mass attaching to the interatrial septum causing obstruction to mitral orifice. Histopathologic investigation confirmed the left atrial mass to be myxoma and left breast nodule to be cancer. Carney complex was considered and lifelong follow-up was advised. Conclusion: Cardiac myxoma may present as a part of a systematic disease entity. In patients with a combination of breast nodule and facial pigmentation, transthoracic echocardiography examination is advised to guide decision-making.

scholarly journals Early recurrent left atrial myxoma in a teenager with de novo mutation of Carney complex

2011 ◽  
Vol 17 (2) ◽  
pp. 108 ◽  
Author(s):  
MilaS Stajevic ◽  
VladimirD Kuburovic ◽  
VladislavA Vukomanovic ◽  
SlavisaM Djuricic
Keyword(s):  
Left Atrial ◽  
De Novo ◽  
Carney Complex ◽  
Atrial Myxoma ◽  
De Novo Mutation ◽  
Left Atrial Myxoma

scholarly journals Recurrent left atrial myxoma in Carney complex

Medicine ◽  
2018 ◽  
Vol 97 (12) ◽  
pp. e0247 ◽  
Author(s):  
Liaoyuan Wang ◽  
Qing Wang ◽  
Yue Zhou ◽  
Qian Xue ◽  
Xiao Sun ◽  
...  
Keyword(s):  
Left Atrial ◽  
Carney Complex ◽  
Atrial Myxoma ◽  
Left Atrial Myxoma

scholarly journals The role of 3D echocardiographic imaging in the differential diagnosis of an atypical left atrial myxoma

2018 ◽  
Vol 88 (3) ◽  
Author(s):  
Domenico Galzerano ◽  
Claudio Pragliola ◽  
Mohamed Al Admawi ◽  
Mario Mallardo ◽  
Sara Di Michele ◽  
...  
Keyword(s):  
Left Atrial ◽  
Multimodality Imaging ◽  
Three Dimensional ◽  
Interatrial Septum ◽  
Atrial Myxoma ◽  
Anatomical Features ◽  
Left Atrial Myxoma ◽  
Dimensional Echocardiography ◽  
Three Dimensional Echocardiography

We describe a case of a left atrial myxoma atypical for its anatomical features and site of attachment. Although an initial multimodality imaging was performed, the diagnosis of myxoma was possible only by three dimensional echocardiography (3DE) which was able to identify the pedicle and the attachment at the base of the interatrial septum, close to the origin of right inferior pulmonary vein. In fact the 3DE can electronically section the structures and obtain unique planes useful in visualizing correctly the anatomical features of the myxomas and as a result, it facilitates the surgical decision planning. Even the anatomical appearance was uncommon at surgery and the diagnosis could be confirmed only by pathology.  This case highlights the diagnostic ability of the 3DE in similar challenging scenarios. 

Twenty-Five Years of Experience with Left Atrial Myxoma

1997 ◽  
Vol 5 (4) ◽  
pp. 207-209
Author(s):  
Binali Mavitaş ◽  
A Tulga Ulus ◽  
Zafer İşcan ◽  
Birol Yamak ◽  
Levent Birincioğlu ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Left Atrial ◽  
Clinical Evidence ◽  
Interatrial Septum ◽  
Atrial Myxoma ◽  
Posterior Leaflet ◽  
Systemic Embolism ◽  
Left Atrial Myxoma ◽  
Septal Defects ◽  
Male Patients

Forty-four patients with left atrial myxoma were operated at Türkiye Yüksek İhtisas Hospital between 1971 and 1996. There were 31 female and 13 male patients. The myxoma arose from the interatrial septum in 43 patients and from the annulus of the posterior leaflet of the mitral valve in one patient. Preoperatively, all patients had dyspnea or tachycardia. Clinical evidence of systemic embolism was detected in 9 patients. The diagnosis was established by angiocardiography in 6 patients and by echocardiography in 38 patients. All patients were treated surgically under cardiopulmonary bypass and the myxomas were resected with their septal attachments. The septal defects were closed with a patch in 12 patients and primarily in 32 patients.

scholarly journals Giant Left Atrial Myxoma Presenting with Cough-Syncope Syndrome

2021 ◽  
Vol 24 (4) ◽  
pp. E7090-E712
Author(s):  
Esra Ertürk tekin
Keyword(s):  
Mitral Valve ◽  
Left Ventricle ◽  
Left Atrium ◽  
Left Atrial ◽  
Interatrial Septum ◽  
Atrial Myxoma ◽  
Transesophageal Echocardiogram ◽  
Left Atrial Myxoma ◽  
Cardiac Surgeon ◽  
The Mean

We report the case of a 41-year-old female patient with symptoms of cerebrovascular accident manifesting with loss of consciousness during episodes of cough. Computed multislice chest tomography showed a 7.3- by 4.15-cm mass in the left atrium. A transesophageal echocardiogram showed a giant mass in the left atrium that passed through the mitral valve to the left ventricle, and severe obstructive stenosis was suggested by the mean transmitral gradient. After a comprehensive assessment of the mass, we decided to perform surgery. The pedunculated and fragile mass was attached to the interatrial septum with its handle, and the majority of it prolapsed through the mitral valve to the left ventricle and became stacked among the mitral valve leaflets. The removed mass was analyzed histopathologically and was found to be a myxoma. It is important for the cardiac surgeon to surgically remove an atrial myxoma because of the risks associated with embolization, including sudden death, as myxoma can block the blood supply from the atrium to the ventricle.

Carney complex: left atrial myxoma in a patient with past pituitary microadenoma and lentiginosis

2021 ◽  
Vol 14 (6) ◽  
pp. e241742
Author(s):  
Jeffrey Spindel ◽  
Mohammad F Mathbout ◽  
Travis Huffman ◽  
Shahab Ghafghazi
Keyword(s):  
Causes Of Death ◽  
Autosomal Dominant ◽  
Carney Complex ◽  
Atrial Myxoma ◽  
Left Atrial Myxoma ◽  
Difficult Diagnosis ◽  
Pituitary Microadenoma ◽  
Cardiac Tumours ◽  
Multiple Neoplasms ◽  
History Of

The Carney complex (CNC) is a rare autosomal dominant genetic complex that is characterised by multiple neoplasms consisting of neuroendocrine and cardiac tumours, with only 750 cases reported worldwide as of 2017. Cardiac tumours, in the context of the CNC, are of unique importance since the leading causes of death in patients with CNC are cardiac. To prevent sudden cardiac death and embolic events, a difficult diagnosis must be made and postdiagnostic screenings must be regular. We present a case of a 52-year-old man, with a medical history of pituitary microadenoma and facial lentiginosis, who presented with dyspnoea 2 months after suffering a cerebrovascular accident.

PP-009 HUGE LEFT ATRIAL MYXOMA ORIGINATING FROM INTERATRIAL SEPTUM

2013 ◽  
Vol 163 (3) ◽  
pp. S84
Author(s):  
İ.O. Yüksel ◽  
H.A. Kasapkara ◽  
E. Ipek ◽  
M. Kurt ◽  
A.S. Yaşar
Keyword(s):  
Left Atrial ◽  
Interatrial Septum ◽  
Atrial Myxoma ◽  
Left Atrial Myxoma
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