Targeting Age-Related Pathways in Heart Failure

During aging, deterioration in cardiac structure and function leads to increased susceptibility to heart failure. The need for interventions to combat this age-related cardiac decline is becoming increasingly urgent as the elderly population continues to grow. Our understanding of cardiac aging, and aging in general, is limited. However, recent studies of age-related decline and its prevention through interventions like exercise have revealed novel pathological and cardioprotective pathways. In this review, we summarize recent findings concerning the molecular mechanisms of age-related heart failure and highlight exercise as a valuable experimental platform for the discovery of much-needed novel therapeutic targets in this chronic disease.

Download Full-text

HEART AND AGE (PART II): CLINICAL MANIFESTATIONS OF AGEING

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2013-4-86-90 ◽

2013 ◽

Vol 12 (4) ◽

pp. 86-90 ◽

Cited By ~ 1

Author(s):

D. U. Akasheva ◽

E. V. Plokhova ◽

I. D. Strazhesko ◽

E. N. Dudinskaya ◽

O. N. Tkacheva

Keyword(s):

Clinical Manifestations ◽

The Elderly ◽

Structure And Function ◽

Disease Development ◽

Cardiac Structure ◽

Age Related ◽

High Prevalence ◽

Cardiac Structure And Function ◽

And Function

Ageing is an inevitable process which affects quality of life and reduces life expectancy. Age-related cardiac changes reduce compensatory reserves of the heart and accelerate the disease development. Such changes in cardiac structure and function, observed in the absence of cardiovascular disease (CVD), are considered age-related. However, taking into account the high prevalence of CVD in the elderly, it is problematic to define the genuine cardiac ageing. This review discusses a range of subclinical cardiac conditions which are common in older people.

Download Full-text

Faculty Opinions recommendation of Cardiac structure and function in heart failure with preserved ejection fraction: baseline findings from the echocardiographic study of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718180959.793489610 ◽

2014 ◽

Author(s):

Chim Lang

Keyword(s):

Heart Failure ◽

Ejection Fraction ◽

Cardiac Function ◽

Structure And Function ◽

Cardiac Structure ◽

Preserved Ejection Fraction ◽

Aldosterone Antagonist ◽

Echocardiographic Study ◽

Cardiac Structure And Function ◽

And Function

Download Full-text

Smoking and Cardiac Structure and Function in the Elderly

Circulation Cardiovascular Imaging ◽

10.1161/circimaging.116.004950 ◽

2016 ◽

Vol 9 (9) ◽

Cited By ~ 29

Author(s):

Wilson Nadruz ◽

Brian Claggett ◽

Alexandra Gonçalves ◽

Gabriela Querejeta-Roca ◽

Miguel M. Fernandes-Silva ◽

...

Keyword(s):

The Elderly ◽

Structure And Function ◽

Cardiac Structure ◽

Cardiac Structure And Function ◽

And Function

Download Full-text

CASE REPORT: UNCONTROLLED HYPERTENSION CONTRIBUTES TO WORSENING OF PRESBYCUS SYMPTOMS IN THE ELDERLY

Journal of Community Medicine and Public Health Research ◽

10.20473/jcmphr.v1i1.20298 ◽

2020 ◽

Vol 1 (1) ◽

pp. 33

Author(s):

Faradila Budi Saputri ◽

Azizah Amimathul Firdha ◽

Safira Rahma ◽

Rieza Rizqy Alda ◽

Syahwina Inayasari ◽

...

Keyword(s):

Heart Failure ◽

Congestive Heart Failure ◽

Hearing Loss ◽

Case Report ◽

Hearing Aids ◽

Social Life ◽

Elderly Population ◽

The Elderly ◽

Uncontrolled Hypertension ◽

Age Related

Presbycusis is a disease that can befall the elderly, caused by a multifactorial process that should be allowed to disrupt communication and social life and cause mental disorders. According to WHO the proportion of the elderly population rises rapidly which is estimated in 2025, there are about 1,2 billion elderly people with a risk of presbycusis. Mr.S was 84 years old, married and had 2 children, complained of hearing loss since 10 years ago on the patient's left ear. The decline in hearing occurred gradually, giving the last 4 years after his wife's death. Patients was taken to Otorhinolaryngologist and expressed age-related hearing impairment and was advised to use hearing aids. Patients are not routinely using hearing aids. In addition, patients have hypertension and heart disease. Patients consumed Captopril 2x1 tablets, Fundifar 2x1, Furosemide 1x40 mg and Fargoxin 1x0.25 mg. Patients do not routinely consumed cardiac medicine and used hearing aids. From the results of heteroanamnesis, physical examination, and audiogram examination conducted in Mr.S patients, it can be concluded that Mr.S suffers from presbycusis with hypertensive and congestive heart failure. Mr.S was advised to routinely have their hearing check to Otorhinolaryngologist the as an evaluation and routine control to Cardiologist.

Download Full-text