scholarly journals Risk of Death or Reinfarction Associated With the Use of Selective Cyclooxygenase-2 Inhibitors and Nonselective Nonsteroidal Antiinflammatory Drugs After Acute Myocardial Infarction

Circulation ◽  
2006 ◽  
Vol 113 (25) ◽  
pp. 2906-2913 ◽  
Author(s):  
Gunnar H. Gislason ◽  
Søren Jacobsen ◽  
Jeppe N. Rasmussen ◽  
Søren Rasmussen ◽  
Pernille Buch ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Cyclooxygenase 2 ◽  
Antiinflammatory Drugs ◽  
Risk Of Death ◽  
Cyclooxygenase 2 Inhibitors

scholarly journals Effect of Selective Cyclooxygenase 2 Inhibitors and Naproxen on Short-term Risk of Acute Myocardial Infarction in the Elderly

2003 ◽  
Vol 163 (4) ◽  
pp. 481 ◽  
Author(s):  
Muhammad Mamdani ◽  
Paula Rochon ◽  
David N. Juurlink ◽  
Geoffrey M. Anderson ◽  
Alex Kopp ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
The Elderly ◽  
Cyclooxygenase 2 ◽  
Short Term ◽  
Cyclooxygenase 2 Inhibitors

scholarly journals Association of Multimodal Pain Management Strategies with Perioperative Outcomes and Resource Utilization

2018 ◽  
Vol 128 (5) ◽  
pp. 891-902 ◽  
Author(s):  
Stavros G. Memtsoudis ◽  
Jashvant Poeran ◽  
Nicole Zubizarreta ◽  
Crispiana Cozowicz ◽  
Eva E. Mörwald ◽  
...  
Keyword(s):  
Resource Utilization ◽  
Odds Ratio ◽  
Multimodal Analgesia ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Cyclooxygenase 2 ◽  
Perioperative Outcomes ◽  
Antiinflammatory Drugs ◽  
Opioid Prescription ◽  
Total Hip ◽  
Cyclooxygenase 2 Inhibitors

Abstract Background Multimodal analgesia is increasingly considered routine practice in joint arthroplasties, but supportive large-scale data are scarce. The authors aimed to determine how the number and type of analgesic modes is associated with reduced opioid prescription, complications, and resource utilization. Methods Total hip/knee arthroplasties (N = 512,393 and N = 1,028,069, respectively) from the Premier Perspective database (2006 to 2016) were included. Analgesic modes considered were opioids, peripheral nerve blocks, acetaminophen, steroids, gabapentin/pregabalin, nonsteroidal antiinflammatory drugs, cyclooxygenase-2 inhibitors, or ketamine. Groups were categorized into “opioids only” and 1, 2, or more than 2 additional modes. Multilevel models measured associations between multimodal analgesia and opioid prescription, cost/length of hospitalization, and opioid-related adverse effects. Odds ratios or percent change and 95% CIs are reported. Results Overall, 85.6% (N = 1,318,165) of patients received multimodal analgesia. In multivariable models, additions of analgesic modes were associated with stepwise positive effects: total hip arthroplasty patients receiving more than 2 modes (compared to “opioids only”) experienced 19% fewer respiratory (odds ratio, 0.81; 95% CI, 0.70 to 0.94; unadjusted 1.0% [N = 1,513] vs. 2.0% [N = 1,546]), 26% fewer gastrointestinal (odds ratio, 0.74; 95% CI, 0.65 to 0.84; unadjusted 1.5% [N = 2,234] vs. 2.5% [N = 1,984]) complications, up to a –18.5% decrease in opioid prescription (95% CI, –19.7% to –17.2%; 205 vs. 300 overall median oral morphine equivalents), and a –12.1% decrease (95% CI, –12.8% to –11.5%; 2 vs. 3 median days) in length of stay (all P < 0.05). Total knee arthroplasty analyses showed similar patterns. Nonsteroidal antiinflammatory drugs and cyclooxygenase-2 inhibitors seemed to be the most effective modalities used. Conclusions While the optimal multimodal regimen is still not known, the authors’ findings encourage the combined use of multiple modalities in perioperative analgesic protocols.

Current Use of Nonsteroidal Antiinflammatory Drugs and the Risk of Acute Myocardial Infarction

2005 ◽  
Vol 25 (4) ◽  
pp. 503-510 ◽  
Author(s):  
Lorenz M. Fischer ◽  
Raymond G. Schlienger ◽  
Christian M. Matter ◽  
Hershel Jick ◽  
Christoph R. Meier
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Antiinflammatory Drugs

Non-aspirin NSAIDs, cyclooxygenase-2 inhibitors and risk for cardiovascular events-stroke, acute myocardial infarction, and death from coronary heart disease

2009 ◽  
Vol 18 (11) ◽  
pp. 1053-1063 ◽  
Author(s):  
Christianne L. Roumie ◽  
Neesha N. Choma ◽  
Lisa Kaltenbach ◽  
Edward F. Mitchel, Jr ◽  
Patrick G. Arbogast ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Events ◽  
Cyclooxygenase 2 ◽  
Cyclooxygenase 2 Inhibitors
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