Determination of Aortic Pulse Wave Velocity From Waveform Decomposition of the Central Aortic Pressure Pulse

Objective: to study the relationship of obesity with arterial stiffness and dynamics of central aortic pressure in women of different ages with preserved and lost reproductive function. Materials and methods: 161 women were examined, who were divided into 3 groups. Two groups with preserved reproductive function: group 1 consisted of 52 young women from 18 to 30 years old (23.85.3 years); group 2 - 54 women aged from 31 to menopause (415.9 years). Group 3 included 55 postmenopausal women (55.45.8 years). All women underwent a clinical examination with anthropometry; questioning; 24-hour monitoring of the dynamics of blood pressure with the determination of indicators of arterial stiffness and daily aortic central pressure; determination of the carotid-femoral pulse wave velocity (cfPWV); study of vascular stiffness by volume sphygmography. Results: women in groups 2 and 3 were comparable in terms of the prevalence of general obesity (GO). Abdominal obesity (AO) was detected in 19.2% of the 1st group; 51.9% of the 2nd and 76.4% of the 3rd group. In 1st group AO has the strongest relationship with aortic pulse wave velocity PWVao (R=0.41, p=0.002) and the corrected to HR75 augmentation index Aixao (R=0.38, p=0.005). In 2nd group AO correlates with cfPWV (R=0.4, p=0.003); GO with PWVao (R=0.38, p=0.005) and aortic cardio-ankle vascular index CAVIao (R=0.48, p=0.001). In the 2nd group AO and GO are also interconnected with central and peripheral pressure. In 3rd group AO correlates with PWVao (R=0.33, p=0.01), cfPWV (R=0.32, p=0.02); GO with the index of the double product IDP (R=0.36, p=0.01). Conclusion: it is necessary to conduct a comprehensive assessment of arterial stiffness and daily dynamics of central aortic pressure in women of all ages, suffering from obesity and, first of all, its abdominal type, in order to early diagnosis of subclinical changes in the vascular wall and central hemodynamic disturbances.

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STRUCTURAL AND FUNCTIONAL VASCULAR CHANGES IN HIGH NORMAL ARTERIAL PRESSURE

BULGARIAN JOURNAL OF VETERINARY MEDICINE ◽

10.15547//tjs.2020.01.002 ◽

2020 ◽

Vol 23 (1) ◽

pp. 7-11

Author(s):

P. Nikolov

Keyword(s):

Arterial Pressure ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Pressure ◽

Pulse Wave ◽

Augmentation Index ◽

Aortic Pressure ◽

Large Arteries ◽

Central Aortic Pressure ◽

Significant Difference

The PURPUSE of the present study is changes in function and structure of large arteries in individuals with High Normal Arterial Pressure (HNAP) to be established. MATERIAL and METHODS: Structural and functional changes in the large arteries were investigated in 80 individuals with HNAP and in 45 with optimal arterial pressure (OAP). In terms of arterial stiffness, pulse wave velocity (PWV), augmentation index (AI), central aortic pressure (CAP), pulse pressure (PP) were followed up in HNAP group. Intima media thickness (IMT), flow-induced vasodilatation (FMD), ankle-brachial index (ABI) were also studied. RESULTS: Significantly increased values of pulse wave velocity, augmentation index, central aortic pressure, pulse pressure are reported in the HNAP group. In terms of IMT and ABI, being in the reference interval, there is no significant difference between HNAP and OAP groups. The calculated cardiovascular risk (CVR) in both groups is low. CONCLUSION: Significantly higher values of pulse wave velocity, augmentation index, central aortic pressure and pulse pressure in the HNAP group are reported.

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