scholarly journals Intracoronary Administration of Allogeneic Adipose Tissue–Derived Mesenchymal Stem Cells Improves Myocardial Perfusion But Not Left Ventricle Function, in a Translational Model of Acute Myocardial Infarction

2017 ◽  
Vol 6 (5) ◽  
Author(s):  
Joaquim Bobi ◽  
Núria Solanes ◽  
Rodrigo Fernández‐Jiménez ◽  
Carlos Galán‐Arriola ◽  
Ana Paula Dantas ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Myocardial Perfusion ◽  
Left Ventricle ◽  
Translational Model ◽  
Left Ventricle Function ◽  
Ventricle Function

scholarly journals Transplantation of Bone Marrow Derived Progenitor Cells in Acute Myocardial Infarction. The First Results

2005 ◽  
Vol 48 (3-4) ◽  
pp. 153-155 ◽  
Author(s):  
Radek Pudil ◽  
Jan Vojáček ◽  
Stanislav Filip ◽  
Pavel Měřička ◽  
Josef Šťásek ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Bone Marrow ◽  
Left Ventricle ◽  
Bone Marrow Cells ◽  
Thrombus Formation ◽  
Autologous Bone Marrow ◽  
Left Ventricle Function ◽  
Direct Stenting ◽  
Ventricle Function

The intracoronary administration of autologous bone marrow cells (BMCs) has been shown to improve the left ventricle function in the course of acute myocardial infarction. Therefore we have started a clinical trial using transplantation of BMCs in the acute phase of myocardial infarction. The aim of our study is to assess the feasibility and safety of this procedure, and effect on the left ventricle function of these patients. We describe the first experience in two patients with acute myocardial infarction reperfused using direct stenting. The aspiration of bone marrow from the sternum provided sufficient amount of the cells for transplantation. No serious ischemia and no changes in coronary artery patency were detected after intracoronary infusion. The left ventricle ejection fraction was increasing throughout the time of three-month follow-up. No other complications (ventricular arrhythmias, reinfarction, thrombus formation) were detected.

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