Abstract WMP120: Critical Role of RGS5 in Modulating Blood-Brain Barrier Integrity During Focal Cerebral Ischemia

Stroke ◽  
2018 ◽  
Vol 49 (Suppl_1) ◽  
Author(s):  
Nikola Sladojevic ◽  
James K Liao
Keyword(s):  
Cerebral Ischemia ◽  
Blood Brain Barrier ◽  
Focal Cerebral Ischemia ◽  
Critical Role ◽  
Brain Barrier ◽  
Barrier Integrity ◽  
Blood Brain ◽  
Blood Brain Barrier Integrity

P2-193: THE ROLE OF EPHA1 IN BLOOD-BRAIN BARRIER INTEGRITY AND NEUROINFLAMMATION IN LATE-ONSET ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_14) ◽  
pp. P743-P743 ◽  
Author(s):  
Helen Anne Owens ◽  
Subuhi Sherwani ◽  
Caroline Tinsley ◽  
Markella Alatsatianos ◽  
Melanie Dunstan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Brain Barrier ◽  
Late Onset ◽  
Brain Barrier ◽  
Barrier Integrity ◽  
Blood Brain ◽  
Blood Brain Barrier Integrity

N-myc downstream-regulated gene 2 protects blood-brain barrier integrity following cerebral ischemia

Glia ◽  
2018 ◽  
Vol 66 (7) ◽  
pp. 1432-1446 ◽  
Author(s):  
Mika Takarada-Iemata ◽  
Akifumi Yoshikawa ◽  
Hieu Minh Ta ◽  
Nahoko Okitani ◽  
Takumi Nishiuchi ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Barrier Integrity ◽  
Blood Brain ◽  
Blood Brain Barrier Integrity

scholarly journals Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity

2020 ◽  
Vol 127 (4) ◽  
pp. 466-482 ◽  
Author(s):  
Koen Veys ◽  
Zheng Fan ◽  
Moheb Ghobrial ◽  
Ann Bouché ◽  
Melissa García-Caballero ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Glucose Transporter ◽  
Brain Barrier ◽  
Barrier Integrity ◽  
Blood Brain ◽  
Blood Brain Barrier Integrity ◽  
Glut1 Glucose Transporter

scholarly journals MiR-34a regulates blood–brain barrier permeability and mitochondrial function by targeting cytochrome c

2015 ◽  
Vol 36 (2) ◽  
pp. 387-392 ◽  
Author(s):  
Mimi Bukeirat ◽  
Saumyendra N Sarkar ◽  
Heng Hu ◽  
Dominic D Quintana ◽  
James W Simpkins ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Blood Brain Barrier ◽  
Critical Role ◽  
Cell Monolayer ◽  
Brain Barrier ◽  
Barrier Integrity ◽  
Blood Brain ◽  
Cerebrovascular Endothelial Cells ◽  
Blood Brain Barrier Integrity

The blood–brain barrier is composed of cerebrovascular endothelial cells and tight junctions, and maintaining its integrity is crucial for the homeostasis of the neuronal environment. Recently, we discovered that mitochondria play a critical role in maintaining blood–brain barrier integrity. We report for the first time a novel mechanism underlying blood–brain barrier integrity: miR-34a mediated regulation of blood–brain barrier through a mitochondrial mechanism. Bioinformatics analysis suggests miR-34a targets several mitochondria-associated gene candidates. We demonstrated that miR-34a triggers the breakdown of blood–brain barrier in cerebrovascular endothelial cell monolayer in vitro, paralleled by reduction of mitochondrial oxidative phosphorylation and adenosine triphosphate production, and decreased cytochrome c levels.

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