scholarly journals Cost-Effectiveness of Dabigatran Compared With Warfarin for Stroke Prevention in Patients With Atrial Fibrillation and Prior Stroke or Transient Ischemic Attack

Stroke ◽  
2012 ◽  
Vol 43 (3) ◽  
pp. 881-883 ◽  
Author(s):  
Hooman Kamel ◽  
S. Claiborne Johnston ◽  
J. Donald Easton ◽  
Anthony S. Kim
Keyword(s):  
Atrial Fibrillation ◽  
Cost Effectiveness ◽  
Transient Ischemic Attack ◽  
Stroke Prevention ◽  
Ischemic Attack ◽  
Prior Stroke

scholarly journals Perindopril-Based Blood Pressure–Lowering Reduces Major Vascular Events in Patients With Atrial Fibrillation and Prior Stroke or Transient Ischemic Attack

Stroke ◽  
2005 ◽  
Vol 36 (10) ◽  
pp. 2164-2169 ◽  
Author(s):  
Hisatomi Arima ◽  
Robert G. Hart ◽  
Sam Colman ◽  
John Chalmers ◽  
Craig Anderson ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Blood Pressure ◽  
Transient Ischemic Attack ◽  
Blood Pressure Lowering ◽  
Vascular Events ◽  
Pressure Lowering ◽  
Ischemic Attack ◽  
Prior Stroke

scholarly journals Prior stroke and transient ischemic attack as risk factors for subsequent stroke in atrial fibrillation patients: A report from the GARFIELD-AF registry

2019 ◽  
Vol 15 (3) ◽  
pp. 308-317
Author(s):  
Werner Hacke ◽  
Jean-Pierre Bassand ◽  
Saverio Virdone ◽  
A John Camm ◽  
David A Fitzmaurice ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Transient Ischemic Attack ◽  
Cardiovascular Death ◽  
Cerebrovascular Event ◽  
Systemic Embolism ◽  
Risk Of Death ◽  
All Cause Mortality ◽  
History Of ◽  
Ischemic Attack ◽  
Prior Stroke

Background It is not always possible to verify whether a patient complaining of symptoms consistent with transient ischemic attack has had an actual cerebrovascular event. Research question To characterize the risk of cardiovascular events associated with a history of stroke/transient ischemic attack in patients with atrial fibrillation. Study design and methods This study investigated the clinical characteristics and outcomes of patients with a history of stroke/transient ischemic attack among 52,014 patients enrolled prospectively in GARFIELD-AF registry. The diagnosis of stroke or transient ischemic attack was not protocol defined but based on physicians’ assessment. Patients’ one-year risk of death, stroke/systemic embolism, and major bleeding was assessed by multivariable Cox regression. Results At enrollment, 5617 (10.9%) patients were reported to have a history of stroke or transient ischemic attack. Patients with stroke or transient ischemic attack were older and had a greater burden of diabetes, moderate-to-severe kidney disease, and atherothrombosis and higher median CHA2DS2-VASc and HAS-BLED scores than those without history of stroke or transient ischemic attack. After adjustment, prior stroke/transient ischemic attack was associated with significantly higher risk for all-cause mortality (hazard ratio (HR), 1.26; 95% confidence interval (CI), 1.12–1.42), cardiovascular death (HR, 1.22; 95% CI, 1.01–1.48), non-cardiovascular death (HR, 1.39; 95% CI, 1.15–1.68), and stroke/systemic embolism (HR, 2.17; 95% CI, 1.80–2.63) than patients without history of stroke/transient ischemic attack. In patients with a prior stroke alone higher risk was observed for all-cause mortality (HR, 1.29; 95% CI, 1.11–1.50), non-cardiovascular death (HR, 1.39; 95% CI, 1.10–1.77), and stroke/systemic embolism (HR, 2.29; 95% CI, 1.83–2.86). No significantly elevated risk of adverse events was seen for patients with history of transient ischemic attack alone. Interpretation A history of prior stroke or transient ischemic attack is a strong independent risk factor for mortality and stroke/systemic embolism. This excess risk is mainly attributed to a history of stroke (with or without transient ischemic attack), whereas history of transient ischemic attack is a weaker predictor. Clinical trial registration: NCT01090362.

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