scholarly journals Mechanisms of tissue factor induction by Porphyromonas gingivalis in human endothelial cells

2021 ◽  
Vol 46 (3) ◽  
pp. 99-104
Author(s):  
So-Hee Kim ◽  
Ji-Yeon Jung ◽  
Won-Jae Kim ◽  
Ok-Joon Kim ◽  
Young Kim ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Tissue Factor ◽  
Porphyromonas Gingivalis ◽  
Human Endothelial Cells

Uremic Medium Disturbs the Hemostatic Balance of Cultured Human Endothelial Cells

2001 ◽  
Vol 86 (10) ◽  
pp. 1099-1105 ◽  
Author(s):  
Mireia Serradell ◽  
Aleix Cases ◽  
María Zurbano ◽  
José Aznar-Salatti ◽  
José López-Pedret ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Tissue Factor ◽  
Northern Blot Analysis ◽  
Human Endothelial Cells ◽  
Perfusion Chamber ◽  
Uremic Serum ◽  
Incubation Periods ◽  
Platelet Deposition ◽  
Accelerated Growth ◽  
Chamber Exposure

SummaryWe have investigated the ability of serum from uremic patients to modify the thrombogenic properties of the endothelium. The effects of uremic medium on the morphology of endothelial cells (ECs), and their resistance to flow was analyzed. The influence of uremic media on the reactivity of the extracellular matrix (ECM) generated by ECs towards normal platelets was evaluated in a parallel-plate perfusion chamber. Exposure of ECs to uremic medium resulted in abnormal cell morphology and signs of an accelerated growth. Detachment of ECs exposed to circulating blood was increased when cells had been grown with media supplemented with uremic serum (21% vs. 14% non exposed). Platelet deposition was significantly elevated on ECMs generated in the presence of uremic media (uremicECMs) (p<0.01 vs. control studies). Effects of uremic serum were not observed at short incubation periods (5 h) but were evident after 24 or 72 h of incubation. Northern blot analysis revealed increased expression of tissue factor (TF) mRNA in ECs exposed to uremic conditions. Immunocytochemical methods detected an augmented expression of TF antigen on uremic ECMs. Incubation of ECMs with an antibody to human tissue factor prevented the increase in platelet deposition observed in uremic ECMs, suggesting that the presence of TF in ECM could be responsible for the enhanced platelet deposition. Results from our study indicate that uremic medium impairs the antithrombotic functions of cultured endothelial cells.

scholarly journals Statin Prevents Tissue Factor Expression in Human Endothelial Cells

Circulation ◽  
2002 ◽  
Vol 105 (15) ◽  
pp. 1756-1759 ◽  
Author(s):  
Masato Eto ◽  
Toshiyuki Kozai ◽  
Francesco Cosentino ◽  
Hana Joch ◽  
Thomas F. Lüscher
Keyword(s):  
Endothelial Cells ◽  
Tissue Factor ◽  
Tissue Factor Expression ◽  
Human Endothelial Cells ◽  
Factor Expression

Malformin-a1 inhibits the binding of interleukin-1β (il1β) and suppresses the expression of tissue factor in human endothelial cells and monocytes

1994 ◽  
Vol 48 (6) ◽  
pp. 1211-1217 ◽  
Author(s):  
Jean-Marc Herbert ◽  
Pierre Savi ◽  
Alain Lalé ◽  
Marie-Claude Laplace ◽  
Nicole Baudry ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Tissue Factor ◽  
Interleukin 1Β ◽  
Human Endothelial Cells ◽  
Malformin A1

Modification of Tissue-Factor mRNA and Protein Response to Thrombin and Interleukin 1 by High Glucose in Cultured Human Endothelial Cells

Diabetes ◽  
1989 ◽  
Vol 38 (2) ◽  
pp. 212-218 ◽  
Author(s):  
D. Boeri ◽  
F. E. Almus ◽  
M. Maiello ◽  
E. Cagliero ◽  
L. V. M. Rao ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Tissue Factor ◽  
High Glucose ◽  
Interleukin 1 ◽  
Human Endothelial Cells ◽  
Protein Response

Evaluation of tissue-factor production by human endothelial cells incubated with three acrylic bone cements

2001 ◽  
Vol 55 (1) ◽  
pp. 131-136 ◽  
Author(s):  
Elisabetta Cenni ◽  
Gabriela Ciapetti ◽  
Donatella Granchi ◽  
Lucia Savarino ◽  
Susanna Stea ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Tissue Factor ◽  
Bone Cements ◽  
Human Endothelial Cells ◽  
Factor Production

PO-09 Expression of alternatively spliced tissue factor in human endothelial cells: induction by inflammatory stimuli and modulation by heparins

2007 ◽  
Vol 120 ◽  
pp. S147
Author(s):  
M. Brambilla ◽  
D. Colnago ◽  
A. Pignieri ◽  
L. Mussoni ◽  
E. Tremoli ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Tissue Factor ◽  
Human Endothelial Cells ◽  
Inflammatory Stimuli ◽  
Alternatively Spliced

Effects of Binding of Ligand (FVIIa) to Induced Tissue Factor in Human Endothelial Cells

2000 ◽  
Vol 98 (4) ◽  
pp. 311-321 ◽  
Author(s):  
Merete T. Wiiger ◽  
Serena Pringle ◽  
Kjell Sverre Pettersen ◽  
Nobuhiro Narahara ◽  
Hans Prydz
Keyword(s):  
Endothelial Cells ◽  
Tissue Factor ◽  
Human Endothelial Cells
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