Differences in Health-Related Quality of Life in Various Forms of Pulmonary Hypertension.

Author(s):  
SC Mathai ◽  
D Boyce ◽  
N Lechtzin ◽  
RE Girgis ◽  
PM Hassoun
2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Abílio Reis ◽  
Mário Santos ◽  
Margarida Vicente ◽  
Inês Furtado ◽  
Célia Cruz ◽  
...  

Background. Health-related quality of life (HRQoL) impairment is common in pulmonary hypertension (PH), but its clinical predictors are not well established. This study aims to characterize the HRQoL of patients with pulmonary arterial hypertension (PAH) and other precapillary forms of PH (pcPH) and to explore its clinical correlates. Materials and Methods. A cross-sectional, observational study of patients with documented PAH and other forms of pcPH. Patients completed two patient-reported outcome measures (PROM): Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) and Nottingham Health Profile (NHP). Clinical characteristics were retrieved from electronic medical records. Results. Mean CAMPHOR and NHP scores for the study population were indicative of a moderate HRQoL impairment. Patients in World Health Organisation Functional Classes (WHO FC) III/IV showed significantly worse HRQoL. The main clinical correlates of HRQoL were WHO FC, 6-minute walking distance (6MWD), and Borg dyspnoea index. Overall quality of life (QoL), assessed through CAMPHOR’s QoL domain, showed patterns comparable to HRQoL measured by both instruments. Conclusions. HRQoL, measured by two different PROMs, is impaired in Portuguese patients with PAH and other forms of pcPH, particularly in patients with increased disease severity. WHO FC, 6MWD, and Borg dyspnoea index are highly correlated with HRQoL and QoL.


2019 ◽  
Vol 73 (9) ◽  
pp. 1904
Author(s):  
Thomas Cascino ◽  
Vallerie McLaughlin ◽  
Caroline Richardson ◽  
Nilofar Behbahani-Nejad ◽  
Victor Moles ◽  
...  

2018 ◽  
Vol 5 (1) ◽  
pp. e000263 ◽  
Author(s):  
Janelle Yorke ◽  
Christi Deaton ◽  
Malcolm Campbell ◽  
Linda McGowen ◽  
Paul Sephton ◽  
...  

IntroductionThe aim of this cohort study was to examine health-related quality of life (HRQoL) and symptomatology in patients with pulmonary hypertension (PH) and explore factors that influence its evolution over time.MethodsA prospective longitudinal multisite cohort study. Participants were recruited from specialist UK PH centres and completed a questionnaire pack at baseline, 6, 12 and 18 months to assess HRQoL (emPHasis-10), dyspnoea, fatigue, sleep, anxiety and depression.Results185 patients entered the study at baseline and 126 (68%) completed month 18. At baseline, patients had significant impairment of HRQoL, anxiety, depression, dyspnoea and severe fatigue. No significant changes, apart from a reduction in the Hospital Anxiety and Depression Scale-Anxiety score (P=0.04), were observed over 18 months. Depression and dyspnoea were predictors of HRQoL (P=0.002 and P=0.03, respectively). Oxygen use was also associated with diminished HRQoL and increased symptom severity.ConclusionPatients with PH experience high levels of symptom severity and the negative impact on HRQoL was unchanged over time. The use of oxygen therapy, in particular, was associated with a significant impact on HRQoL. Further study of factors impacting HRQoL and interventions that target a combination of physiological and psychosocial consequences of living with PH are needed.


2021 ◽  
Author(s):  
Sarfraz A Saleemi ◽  
Reem Alameer ◽  
Toka Alsulaim ◽  
Naif S Alghasab

Background: Pulmonary Hypertension (PH) is a chronic progressive disease which affects quality of life. The prevalence of mood disorders in PH patients in Saudi Arabia is not known. Objectives: This is a prospective observational study to investigate the prevalence of anxiety and depression in patients with pulmonary hypertension and its effect on health-related quality of life (HRQoL). Methods: Forty-two PH patients were evaluated for mood disorders by using Hospital Anxiety and Depression Scale (HADS) and health related quality of life was assessed with The Short Form 36 (SF-36) Health Survey questionnaire. Results: Mean age for the cohort was 42.8 (13.3) years and 31(73%) were female. Mean pulmonary artery pressure was 46.4 (15) mm Hg and 25 (60%) patients had severe PH (mPAP >45 mmHg). Thirty-eight (90%) patients were in World Health Organization Functional Class (WHO-FC) II/III and 5 (10%) class IV. HADS anxiety and depression score was positive (11-21) in 4 (10%) and 6 (14%) patients respectively. Presence of anxiety and/or depression affected HRQoL. Conclusion: Prevalence of anxiety and depression in PH patients in Saudi Arabia is low (10% and 14% respectively) compared to published studies. The low prevalence may be explained by cultural and social differences and strong family support.


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